SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 4r2g SURFACE PROTEIN
GP160
(Human
immunodeficiency
virus
1) 		4 / 7 TYR E 435
TRP E 112
PHE E 382
TRP E 427
 None
 1.46A 1b2iA-4r2gE:
undetectable		 1b2iA-4r2gE:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4r2g SURFACE PROTEIN
GP160
(Human
immunodeficiency
virus
1) 		4 / 7 THR E 388
PHE E 391
THR E 362
ARG E 469
 NAG  E 515 (-3.9A)
None
None
None
 1.03A 2kotA-4r2gE:
undetectable		 2kotA-4r2gE:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r2g SURFACE PROTEIN
GP160
(Human
immunodeficiency
virus
1) 		4 / 6 ILE E 443
GLU E 381
ALA E 329
ASN E 302
 None
 1.07A 3pgyA-4r2gE:
undetectable
3pgyB-4r2gE:
undetectable		 3pgyA-4r2gE:
22.93
3pgyB-4r2gE:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 4r2g SURFACE PROTEIN
GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ASP E 279
GLY E 472
ASP E 275
PHE E 391
THR E 455
 NAG  E 512 (-4.3A)
None
None
None
None
 1.14A 3prsA-4r2gE:
undetectable		 3prsA-4r2gE:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4r2g SURFACE PROTEIN
GP160
(Human
immunodeficiency
virus
1) 		4 / 5 PHE E 468
ILE E 359
GLN E 352
ARG E 456
 None
 0.99A 5jm4A-4r2gE:
undetectable		 5jm4A-4r2gE:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4r2g SURFACE PROTEIN
GP160
(Human
immunodeficiency
virus
1) 		4 / 4 PHE E 468
ILE E 359
GLN E 352
ARG E 456
 None
 1.00A 5jm4B-4r2gE:
undetectable		 5jm4B-4r2gE:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4r2g SURFACE PROTEIN
GP160
(Human
immunodeficiency
virus
1) 		4 / 6 PHE E 468
LEU E 452
ARG E 469
GLY E 471
 None
 1.02A 5o4yA-4r2gE:
undetectable		 5o4yA-4r2gE:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4r2g SURFACE PROTEIN
GP160
(Human
immunodeficiency
virus
1) 		5 / 12 VAL E 108
ASP E 107
LEU E 453
ASP E 474
GLN E 287
 None
 1.28A 5syeB-4r2gE:
undetectable		 5syeB-4r2gE:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 4r2g SURFACE PROTEIN
GP160
(Human
immunodeficiency
virus
1) 		4 / 7 ASN E 339
ALA E 336
GLU E 290
LEU E 342
 NAG  E 514 (-2.4A)
NAG  E 514 ( 4.6A)
None
None
 1.05A 6ci6A-4r2gE:
undetectable		 6ci6A-4r2gE:
11.97