SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4r2h STIV B204 ATPASE
(Sulfolobus
turreted
icosahedral
virus
1) 		3 / 3 SER A  15
HIS A 201
ASP A 192
 None
 0.67A 2oxtA-4r2hA:
2.3		 2oxtA-4r2hA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4r2h STIV B204 ATPASE
(Sulfolobus
turreted
icosahedral
virus
1) 		5 / 12 ALA A 176
LEU A 189
ILE A 190
GLY A  11
ILE A 168
 None
 1.20A 3lbdA-4r2hA:
undetectable		 3lbdA-4r2hA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4r2h STIV B204 ATPASE
(Sulfolobus
turreted
icosahedral
virus
1) 		4 / 9 TYR A  24
PHE A 188
HIS A 201
ILE A 134
 None
 1.01A 4jvlA-4r2hA:
undetectable		 4jvlA-4r2hA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4r2h STIV B204 ATPASE
(Sulfolobus
turreted
icosahedral
virus
1) 		5 / 12 ASP A  39
LEU A 133
PHE A 109
ILE A 102
HIS A  41
 ZN  A 300 (-2.1A)
None
None
None
ZN  A 300 (-3.0A)
 1.41A 5dv4A-4r2hA:
undetectable		 5dv4A-4r2hA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4r2h STIV B204 ATPASE
(Sulfolobus
turreted
icosahedral
virus
1) 		4 / 7 PHE A  53
ILE A  37
ASP A  40
ASN A  56
 None
 1.06A 5n5dA-4r2hA:
3.0		 5n5dA-4r2hA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4r2h STIV B204 ATPASE
(Sulfolobus
turreted
icosahedral
virus
1) 		5 / 12 ILE A 155
ILE A 204
PHE A 157
TYR A  36
ILE A  38
 None
 1.07A 6mkeB-4r2hA:
undetectable
6mkeC-4r2hA:
undetectable		 6mkeB-4r2hA:
14.62
6mkeC-4r2hA:
14.62