SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		5 / 12 GLY A  75
GLY A  78
ILE A 128
VAL A  96
ALA A 127
 None
 1.02A 1v2xA-4r2vA:
undetectable		 1v2xA-4r2vA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		5 / 12 TYR A 252
ALA A 271
GLY A 269
GLY A 265
ARG A 281
 None
 1.11A 2okcA-4r2vA:
undetectable		 2okcA-4r2vA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		5 / 12 TYR A 252
ALA A 271
GLY A 269
GLY A 265
ARG A 281
 None
 1.09A 2okcB-4r2vA:
undetectable		 2okcB-4r2vA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		4 / 6 ILE A 199
ARG A 200
LEU A 201
ASP A 239
 None
 0.93A 2rlfA-4r2vA:
undetectable
2rlfD-4r2vA:
undetectable		 2rlfA-4r2vA:
8.64
2rlfD-4r2vA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		5 / 10 THR A 118
PRO A  72
GLY A  75
GLY A 126
ALA A 127
 None
 1.26A 3pp7B-4r2vA:
3.9		 3pp7B-4r2vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		4 / 8 GLY A  50
LEU A  53
ILE A  54
ILE A  69
 LLP  A  46 ( 3.9A)
None
None
None
 0.78A 4em2A-4r2vA:
0.4		 4em2A-4r2vA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		3 / 3 PRO A 283
LEU A 282
GLN A 287
 None
 0.64A 4pevB-4r2vA:
2.5		 4pevB-4r2vA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		4 / 6 TYR A 156
PRO A 144
LEU A 145
LEU A  53
 None
 1.08A 5tl8A-4r2vA:
undetectable		 5tl8A-4r2vA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		5 / 12 PHE A 185
ILE A 179
PHE A 175
ALA A 274
ALA A  34
 None
 1.23A 5vcgA-4r2vA:
undetectable		 5vcgA-4r2vA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		5 / 12 LEU A  83
ILE A  11
VAL A  45
GLY A  43
GLY A  42
 None
None
LLP  A  46 ( 2.7A)
None
None
 1.09A 5wyqA-4r2vA:
undetectable		 5wyqA-4r2vA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		5 / 10 GLY A 285
ILE A  32
ALA A 279
LEU A 282
PHE A 233
 None
 1.02A 5zjiA-4r2vA:
undetectable
5zjiJ-4r2vA:
undetectable		 5zjiA-4r2vA:
14.66
5zjiJ-4r2vA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		3 / 3 THR A 290
ALA A 275
LYS A 277
 None
 0.78A 6fgcA-4r2vA:
undetectable		 6fgcA-4r2vA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		5 / 9 THR A 253
GLY A 269
TYR A 305
HIS A  38
GLU A 222
 None
 1.15A 6gnfA-4r2vA:
3.0		 6gnfA-4r2vA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		4 / 8 ASP A 239
ILE A 199
ARG A 200
ASN A 171
 None
 1.25A 6hisA-4r2vA:
undetectable
6hisB-4r2vA:
undetectable		 6hisA-4r2vA:
14.81
6hisB-4r2vA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		4 / 8 ASP A 239
ILE A 199
ARG A 200
ASN A 171
 None
 1.25A 6hisB-4r2vA:
undetectable
6hisC-4r2vA:
undetectable		 6hisB-4r2vA:
14.81
6hisC-4r2vA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		4 / 8 ASP A 239
ILE A 199
ARG A 200
ASN A 171
 None
 1.26A 6hisC-4r2vA:
undetectable
6hisD-4r2vA:
undetectable		 6hisC-4r2vA:
14.81
6hisD-4r2vA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		4 / 8 ASP A 239
ILE A 199
ARG A 200
ASN A 171
 None
 1.25A 6hisD-4r2vA:
undetectable
6hisE-4r2vA:
undetectable		 6hisD-4r2vA:
14.81
6hisE-4r2vA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		4 / 8 ASN A 171
ASP A 239
ILE A 199
ARG A 200
 None
 1.26A 6hisA-4r2vA:
undetectable
6hisE-4r2vA:
undetectable		 6hisA-4r2vA:
14.81
6hisE-4r2vA:
14.81