SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4r33 NOSL
(Streptomyces
actuosus) 		4 / 6 HIS A 267
LEU A 271
PHE A 234
VAL A 231
 None
 1.24A 1ibgH-4r33A:
undetectable		 1ibgH-4r33A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 12 LEU A 261
LEU A 280
ALA A 276
ALA A 278
VAL A 309
 None
 1.29A 1kt4A-4r33A:
undetectable		 1kt4A-4r33A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 11 LEU A 128
ILE A 339
THR A  85
LEU A 376
THR A 322
 None
None
None
None
TRP  A 503 (-4.4A)
 1.24A 1tw4A-4r33A:
undetectable		 1tw4A-4r33A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 9 THR A 312
GLU A  73
TYR A 302
LEU A 305
GLU A 324
 None
 1.26A 2azqA-4r33A:
undetectable		 2azqA-4r33A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4r33 NOSL
(Streptomyces
actuosus) 		4 / 6 SER A 153
GLU A 143
TYR A 144
CYH A  95
 None
None
None
SF4  A 502 (-2.2A)
 1.20A 2x7hA-4r33A:
undetectable		 2x7hA-4r33A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4r33 NOSL
(Streptomyces
actuosus) 		4 / 6 MET A 199
SER A 233
ARG A 230
GLY A 177
 None
None
SAH  A 501 (-2.9A)
SAH  A 501 ( 3.9A)
 1.28A 2y7pA-4r33A:
undetectable		 2y7pA-4r33A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4r33 NOSL
(Streptomyces
actuosus) 		4 / 5 ILE A 339
SER A 340
PRO A 341
PRO A  88
 None
TRP  A 503 (-2.8A)
None
TRP  A 503 (-4.0A)
 1.10A 3bjwC-4r33A:
undetectable		 3bjwC-4r33A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 11 TYR A 242
LEU A 187
GLY A 158
ASP A 195
VAL A 172
 None
 1.05A 3lxiB-4r33A:
undetectable		 3lxiB-4r33A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 12 GLY A 142
GLY A 177
GLU A 204
ARG A 230
LEU A 250
 SAH  A 501 (-3.6A)
SAH  A 501 ( 3.9A)
SAH  A 501 (-2.7A)
SAH  A 501 (-2.9A)
SAH  A 501 ( 3.6A)
 0.76A 3t7vA-4r33A:
28.8		 3t7vA-4r33A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 12 GLY A 142
GLY A 177
GLU A 204
ARG A 230
LEU A 253
 SAH  A 501 (-3.6A)
SAH  A 501 ( 3.9A)
SAH  A 501 (-2.7A)
SAH  A 501 (-2.9A)
None
 1.22A 3t7vA-4r33A:
28.8		 3t7vA-4r33A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 11 LEU A  40
SER A  49
GLU A  45
LEU A  57
VAL A 309
 None
 1.35A 3tbgA-4r33A:
undetectable		 3tbgA-4r33A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 10 TYR A 242
LEU A 187
GLY A 158
ASP A 195
VAL A 172
 None
 1.04A 4c9nB-4r33A:
undetectable		 4c9nB-4r33A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 10 TYR A 242
LEU A 187
GLY A 158
ASP A 195
VAL A 172
 None
 1.07A 4c9pB-4r33A:
undetectable		 4c9pB-4r33A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 12 LEU A  89
VAL A 137
ALA A 164
GLU A 123
THR A 122
 None
 1.23A 4fiaA-4r33A:
undetectable		 4fiaA-4r33A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 12 LEU A  89
VAL A 137
ALA A 164
GLU A 123
THR A 122
 None
 1.23A 4fiaA-4r33A:
undetectable		 4fiaA-4r33A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4r33 NOSL
(Streptomyces
actuosus) 		4 / 8 ILE A 127
GLU A 132
GLN A 124
ILE A 121
 None
 0.95A 4mj8A-4r33A:
undetectable		 4mj8A-4r33A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4r33 NOSL
(Streptomyces
actuosus) 		7 / 12 CYH A 102
ASN A 175
PHE A 202
LYS A 224
LEU A 250
ALA A 288
PHE A 364
 SF4  A 502 (-2.4A)
SAH  A 501 (-3.9A)
SAH  A 501 ( 4.6A)
SAH  A 501 ( 2.8A)
SAH  A 501 ( 3.6A)
SAH  A 501 ( 3.7A)
SAH  A 501 ( 3.8A)
 0.70A 4rtbA-4r33A:
39.7		 4rtbA-4r33A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 4r33 NOSL
(Streptomyces
actuosus) 		3 / 3 GLU A 204
ARG A 230
GLN A 363
 SAH  A 501 (-2.7A)
SAH  A 501 (-2.9A)
SAH  A 501 (-3.2A)
 0.61A 4rtbA-4r33A:
39.8		 4rtbA-4r33A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4r33 NOSL
(Streptomyces
actuosus) 		3 / 3 MET A 179
GLU A 183
LEU A 187
 None
 0.52A 4v2oB-4r33A:
undetectable		 4v2oB-4r33A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4r33 NOSL
(Streptomyces
actuosus) 		6 / 12 GLY A 142
GLU A 143
PHE A 202
LEU A 250
PRO A 283
ALA A 288
 SAH  A 501 (-3.6A)
None
SAH  A 501 ( 4.6A)
SAH  A 501 ( 3.6A)
None
SAH  A 501 ( 3.7A)
 0.60A 4wcxC-4r33A:
38.0		 4wcxC-4r33A:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4r33 NOSL
(Streptomyces
actuosus) 		4 / 6 CYH A 102
ASN A 175
GLU A 204
LYS A 224
 SF4  A 502 (-2.4A)
SAH  A 501 (-3.9A)
SAH  A 501 (-2.7A)
SAH  A 501 ( 2.8A)
 0.50A 4wcxC-4r33A:
38.1		 4wcxC-4r33A:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4r33 NOSL
(Streptomyces
actuosus) 		4 / 8 ARG A 150
ARG A 230
VAL A 222
ASP A 226
 None
SAH  A 501 (-2.9A)
None
None
 1.06A 4xqgA-4r33A:
undetectable		 4xqgA-4r33A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4r33 NOSL
(Streptomyces
actuosus) 		4 / 8 ARG A 150
ARG A 230
VAL A 222
ASP A 226
 None
SAH  A 501 (-2.9A)
None
None
 1.06A 4xqgB-4r33A:
undetectable		 4xqgB-4r33A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4r33 NOSL
(Streptomyces
actuosus) 		3 / 3 ASN A 246
SER A 281
ARG A 323
 None
TRP  A 503 ( 4.9A)
TRP  A 503 ( 2.9A)
 0.92A 5b2qA-4r33A:
undetectable		 5b2qA-4r33A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_NPSA602_1
(SERUM ALBUMIN)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 12 CYH A 200
PHE A 234
LEU A 271
SER A 281
LEU A 280
 None
None
None
TRP  A 503 ( 4.9A)
None
 1.32A 5dbyA-4r33A:
undetectable		 5dbyA-4r33A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4r33 NOSL
(Streptomyces
actuosus) 		4 / 7 SER A 362
ASP A 345
PRO A 348
TYR A 349
 None
 1.17A 5l1fC-4r33A:
2.5		 5l1fC-4r33A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4r33 NOSL
(Streptomyces
actuosus) 		5 / 12 GLY A 337
HIS A  84
TYR A 173
THR A 277
CYH A 313
 None
GOL  A 504 (-4.2A)
GOL  A 504 (-4.6A)
None
None
 1.48A 5lsuB-4r33A:
undetectable		 5lsuB-4r33A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4r33 NOSL
(Streptomyces
actuosus) 		3 / 3 GLU A 126
HIS A 130
ARG A 135
 None
 0.93A 5uunA-4r33A:
undetectable		 5uunA-4r33A:
20.53