SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		3 / 3 ARG A  89
GLY A 122
ASP A 120
 None
 0.58A 1kf6A-4r38A:
undetectable
1kf6B-4r38A:
undetectable		 1kf6A-4r38A:
15.44
1kf6B-4r38A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		4 / 6 ARG A  53
SER A  46
GLY A  44
THR A  43
 None
 1.08A 2f7fA-4r38A:
undetectable		 2f7fA-4r38A:
13.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		8 / 12 ASN A  54
CYH A  55
ARG A  56
GLN A  59
ASN A  87
ASN A  97
LEU A  99
GLN A 118
 RBF  A 201 (-2.6A)
RBF  A 201 (-3.3A)
RBF  A 201 (-3.7A)
RBF  A 201 (-3.0A)
RBF  A 201 (-2.4A)
RBF  A 201 (-3.7A)
RBF  A 201 (-4.2A)
RBF  A 201 (-4.0A)
 0.39A 4kukA-4r38A:
18.4		 4kukA-4r38A:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		5 / 9 LEU A  58
VAL A  68
ILE A  85
PHE A 114
GLY A 116
 RBF  A 201 (-3.9A)
RBF  A 201 (-3.3A)
RBF  A 201 ( 4.2A)
RBF  A 201 (-4.4A)
RBF  A 201 ( 3.3A)
 0.58A 4kukA-4r38A:
18.4		 4kukA-4r38A:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		8 / 12 ASN A  54
CYH A  55
ARG A  56
GLN A  59
ASN A  87
ASN A  97
LEU A  99
GLN A 118
 RBF  A 201 (-2.6A)
RBF  A 201 (-3.3A)
RBF  A 201 (-3.7A)
RBF  A 201 (-3.0A)
RBF  A 201 (-2.4A)
RBF  A 201 (-3.7A)
RBF  A 201 (-4.2A)
RBF  A 201 (-4.0A)
 0.35A 4kuoA-4r38A:
18.6		 4kuoA-4r38A:
36.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		5 / 12 SER A  46
ALA A  90
PHE A  39
LEU A  99
VAL A  35
 None
None
None
RBF  A 201 (-4.2A)
None
 1.32A 4nc3A-4r38A:
undetectable		 4nc3A-4r38A:
17.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		6 / 12 ALA A  23
CYH A  55
ALA A  72
ILE A  75
ILE A  85
ASN A  87
 RBF  A 201 ( 3.4A)
RBF  A 201 (-3.3A)
RBF  A 201 ( 3.3A)
RBF  A 201 (-4.2A)
RBF  A 201 ( 4.2A)
RBF  A 201 (-2.4A)
 1.35A 4r3aA-4r38A:
17.0		 4r3aA-4r38A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		12 / 12 ALA A  23
CYH A  55
ARG A  56
GLN A  59
ALA A  72
ILE A  75
ILE A  85
ASN A  87
ASN A  97
LEU A  99
MET A 101
GLN A 118
 RBF  A 201 ( 3.4A)
RBF  A 201 (-3.3A)
RBF  A 201 (-3.7A)
RBF  A 201 (-3.0A)
RBF  A 201 ( 3.3A)
RBF  A 201 (-4.2A)
RBF  A 201 ( 4.2A)
RBF  A 201 (-2.4A)
RBF  A 201 (-3.7A)
RBF  A 201 (-4.2A)
RBF  A 201 (-3.2A)
RBF  A 201 (-4.0A)
 0.34A 4r3aA-4r38A:
17.0		 4r3aA-4r38A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		10 / 10 THR A  21
ILE A  25
GLU A  30
ASN A  54
LEU A  58
GLN A  59
VAL A  68
LEU A  71
MET A 101
PHE A 114
 RBF  A 201 (-3.1A)
None
None
RBF  A 201 (-2.6A)
RBF  A 201 (-3.9A)
RBF  A 201 (-3.0A)
RBF  A 201 (-3.3A)
RBF  A 201 ( 3.6A)
RBF  A 201 (-3.2A)
RBF  A 201 (-4.4A)
 0.59A 4r3aB-4r38A:
16.8		 4r3aB-4r38A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		5 / 10 THR A  21
ILE A  75
LEU A  58
MET A 101
PHE A 114
 RBF  A 201 (-3.1A)
RBF  A 201 (-4.2A)
RBF  A 201 (-3.9A)
RBF  A 201 (-3.2A)
RBF  A 201 (-4.4A)
 1.42A 4r3aB-4r38A:
16.8		 4r3aB-4r38A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		7 / 12 ALA A  23
LEU A  32
CYH A  55
ALA A  72
ILE A  75
ILE A  85
ASN A  87
 RBF  A 201 ( 3.4A)
None
RBF  A 201 (-3.3A)
RBF  A 201 ( 3.3A)
RBF  A 201 (-4.2A)
RBF  A 201 ( 4.2A)
RBF  A 201 (-2.4A)
 1.33A 4r3aB-4r38A:
16.8		 4r3aB-4r38A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		12 / 12 ALA A  23
LEU A  32
CYH A  55
ARG A  56
ALA A  72
ILE A  75
ILE A  85
ASN A  87
ASN A  97
LEU A  99
GLY A 116
GLN A 118
 RBF  A 201 ( 3.4A)
None
RBF  A 201 (-3.3A)
RBF  A 201 (-3.7A)
RBF  A 201 ( 3.3A)
RBF  A 201 (-4.2A)
RBF  A 201 ( 4.2A)
RBF  A 201 (-2.4A)
RBF  A 201 (-3.7A)
RBF  A 201 (-4.2A)
RBF  A 201 ( 3.3A)
RBF  A 201 (-4.0A)
 0.48A 4r3aB-4r38A:
16.8		 4r3aB-4r38A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2
(Erythrobacter
litoralis) 		6 / 12 ALA A  23
LEU A  32
CYH A  55
ARG A  56
ILE A  75
ASN A  97
 RBF  A 201 ( 3.4A)
None
RBF  A 201 (-3.3A)
RBF  A 201 (-3.7A)
RBF  A 201 (-4.2A)
RBF  A 201 (-3.7A)
 1.05A 4r3aB-4r38A:
16.8		 4r3aB-4r38A:
100.00