SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 9 ASN A 250
ASP A 282
ILE A 287
PRO A 288
THR A 324
MG  A 401 ( 2.4A)
ANP  A 402 (-2.7A)
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
ANP  A 402 (-3.6A)
0.92A 1aj6A-4r39A:
4.1
1aj6A-4r39A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 9 ASP A 282
ARG A 285
ILE A 287
PRO A 288
THR A 324
ANP  A 402 (-2.7A)
None
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
ANP  A 402 (-3.6A)
1.24A 1aj6A-4r39A:
4.1
1aj6A-4r39A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
4 / 8 GLN A 335
LEU A 276
LEU A 205
TYR A 204
None
1.19A 1hk2A-4r39A:
undetectable
1hk2A-4r39A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ARG A 285
ILE A 287
PRO A 288
ASP A 290
THR A 324
None
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
None
ANP  A 402 (-3.6A)
1.30A 1kijA-4r39A:
4.0
1kijA-4r39A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ASP A 282
ILE A 287
PRO A 288
ASP A 290
THR A 324
ANP  A 402 (-2.7A)
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
None
ANP  A 402 (-3.6A)
0.99A 1kijA-4r39A:
4.0
1kijA-4r39A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ASN A 250
ARG A 285
ILE A 287
PRO A 288
THR A 324
MG  A 401 ( 2.4A)
None
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
ANP  A 402 (-3.6A)
1.19A 1kijB-4r39A:
4.6
1kijB-4r39A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ASN A 250
ASP A 282
ILE A 287
PRO A 288
THR A 324
MG  A 401 ( 2.4A)
ANP  A 402 (-2.7A)
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
ANP  A 402 (-3.6A)
0.95A 1kijB-4r39A:
4.6
1kijB-4r39A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ASP A 282
ILE A 287
PRO A 288
ASP A 290
THR A 324
ANP  A 402 (-2.7A)
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
None
ANP  A 402 (-3.6A)
1.00A 1kijB-4r39A:
4.6
1kijB-4r39A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 11 TYR A 204
VAL A 278
ILE A 328
LEU A 148
LEU A 307
None
1.14A 1mrqA-4r39A:
undetectable
1mrqA-4r39A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
4 / 5 VAL A 232
VAL A 270
ASP A 228
SER A 268
None
1.18A 2x45A-4r39A:
undetectable
2x45A-4r39A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
6 / 12 ASN A 250
ASP A 282
ARG A 285
PRO A 288
ASP A 290
THR A 324
MG  A 401 ( 2.4A)
ANP  A 402 (-2.7A)
None
ANP  A 402 ( 4.4A)
None
ANP  A 402 (-3.6A)
1.30A 3lpsA-4r39A:
3.6
3lpsA-4r39A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ILE A 339
LEU A 182
LEU A 148
ILE A 240
LEU A 311
None
0.98A 3tq9A-4r39A:
undetectable
3tq9A-4r39A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 SER A 245
ILE A 208
TYR A 204
LEU A 205
LEU A 311
None
1.25A 3vn2A-4r39A:
undetectable
3vn2A-4r39A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
4 / 8 ILE A 151
ARG A 175
PRO A 294
TRP A 293
None
ANP  A 402 (-3.8A)
None
ANP  A 402 (-4.4A)
1.26A 4f4dB-4r39A:
undetectable
4f4dB-4r39A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
4 / 8 TYR A 204
VAL A 278
LEU A 148
LEU A 307
None
1.02A 4l1xA-4r39A:
undetectable
4l1xA-4r39A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 9 TYR A 204
VAL A 278
ILE A 328
LEU A 148
LEU A 307
None
1.16A 4l1xB-4r39A:
undetectable
4l1xB-4r39A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ASP A 282
ARG A 285
ILE A 287
PRO A 288
ASP A 290
ANP  A 402 (-2.7A)
None
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
None
1.29A 4uroC-4r39A:
4.1
4uroC-4r39A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ARG A 285
ILE A 287
PRO A 288
ASP A 290
THR A 324
None
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
None
ANP  A 402 (-3.6A)
1.17A 4uroD-4r39A:
5.3
4uroD-4r39A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ASN A 250
ARG A 285
ILE A 287
PRO A 288
THR A 324
MG  A 401 ( 2.4A)
None
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
ANP  A 402 (-3.6A)
1.13A 4uroD-4r39A:
5.3
4uroD-4r39A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ASN A 250
ASP A 282
ILE A 287
PRO A 288
THR A 324
MG  A 401 ( 2.4A)
ANP  A 402 (-2.7A)
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
ANP  A 402 (-3.6A)
0.90A 4uroD-4r39A:
5.3
4uroD-4r39A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 ASP A 282
ILE A 287
PRO A 288
ASP A 290
THR A 324
ANP  A 402 (-2.7A)
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
None
ANP  A 402 (-3.6A)
0.88A 4uroD-4r39A:
5.3
4uroD-4r39A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 TYR A 204
VAL A 278
ILE A 328
LEU A 148
LEU A 307
None
1.08A 4yvpB-4r39A:
undetectable
4yvpB-4r39A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 LEU A 332
SER A 333
GLN A 334
ILE A 240
VAL A 278
None
1.04A 5dpdA-4r39A:
undetectable
5dpdA-4r39A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 LEU A 332
SER A 333
GLN A 334
ILE A 240
VAL A 278
None
1.17A 5dpdB-4r39A:
undetectable
5dpdB-4r39A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 12 LEU A 266
VAL A 308
THR A 249
LEU A 252
ALA A 251
None
None
None
None
ANP  A 402 ( 4.1A)
1.15A 6djzC-4r39A:
undetectable
6djzC-4r39A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 10 LEU A 242
SER A 245
ASP A 216
ILE A 303
GLY A 300
None
None
None
None
ANP  A 402 (-3.3A)
1.46A 6dlzA-4r39A:
undetectable
6dlzD-4r39A:
undetectable
6dlzA-4r39A:
17.04
6dlzD-4r39A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 10 ILE A 303
GLY A 300
LEU A 242
SER A 245
ASP A 216
None
ANP  A 402 (-3.3A)
None
None
None
1.46A 6dlzB-4r39A:
undetectable
6dlzC-4r39A:
undetectable
6dlzB-4r39A:
17.04
6dlzC-4r39A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 10 LEU A 242
SER A 245
ASP A 216
ILE A 303
GLY A 300
None
None
None
None
ANP  A 402 (-3.3A)
1.46A 6dm1A-4r39A:
undetectable
6dm1D-4r39A:
undetectable
6dm1A-4r39A:
17.04
6dm1D-4r39A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis)
5 / 10 ILE A 303
GLY A 300
LEU A 242
SER A 245
ASP A 216
None
ANP  A 402 (-3.3A)
None
None
None
1.47A 6dm1B-4r39A:
undetectable
6dm1C-4r39A:
undetectable
6dm1B-4r39A:
17.04
6dm1C-4r39A:
17.04