SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		5 / 11 PHE A 140
GLU A 148
LEU A 143
GLY A  60
PHE A  61
 EDO  A 303 (-2.8A)
None
None
None
EDO  A 303 ( 4.5A)
 1.25A 1hvyC-4r3fA:
undetectable		 1hvyC-4r3fA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		5 / 9 PHE A 140
GLU A 148
LEU A 143
GLY A  60
PHE A  61
 EDO  A 303 (-2.8A)
None
None
None
EDO  A 303 ( 4.5A)
 1.11A 1i00A-4r3fA:
undetectable		 1i00A-4r3fA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		5 / 7 PHE A  40
PHE A 139
PHE A 141
PHE A  54
VAL A  15
 None
 1.42A 1lh6A-4r3fA:
undetectable		 1lh6A-4r3fA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.31A 1p6kA-4r3fA:
undetectable		 1p6kA-4r3fA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.29A 1rs6A-4r3fA:
undetectable		 1rs6A-4r3fA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.29A 1rs6B-4r3fA:
undetectable		 1rs6B-4r3fA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.28A 1rs7B-4r3fA:
undetectable		 1rs7B-4r3fA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		3 / 3 ASP A 110
PHE A 156
ASN A 107
 None
 0.87A 1sg9B-4r3fA:
undetectable		 1sg9B-4r3fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.29A 1zzqA-4r3fA:
undetectable		 1zzqA-4r3fA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.30A 1zzqB-4r3fA:
undetectable		 1zzqB-4r3fA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.30A 1zzuA-4r3fA:
undetectable		 1zzuA-4r3fA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		5 / 12 ALA A 127
GLY A 125
LEU A 149
LEU A 124
GLY A 136
 EDO  A 303 ( 3.2A)
None
EDO  A 303 ( 4.0A)
None
None
 1.12A 2f8lA-4r3fA:
undetectable		 2f8lA-4r3fA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		3 / 3 ARG A 158
GLN A  10
PRO A  11
 None
 0.90A 2qhfA-4r3fA:
undetectable		 2qhfA-4r3fA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 ILE A  17
PHE A  40
GLY A  65
GLY A  66
 None
 0.79A 2qx4A-4r3fA:
undetectable
2qx4B-4r3fA:
undetectable		 2qx4A-4r3fA:
23.79
2qx4B-4r3fA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 6 ILE A  17
PHE A  40
GLY A  65
GLY A  66
 None
 0.82A 2qx6A-4r3fA:
undetectable
2qx6B-4r3fA:
undetectable		 2qx6A-4r3fA:
23.79
2qx6B-4r3fA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		5 / 10 PHE A 140
GLU A 148
LEU A 143
GLY A  60
PHE A  61
 EDO  A 303 (-2.8A)
None
None
None
EDO  A 303 ( 4.5A)
 1.06A 2tsrC-4r3fA:
undetectable		 2tsrC-4r3fA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		5 / 11 ASP A  23
ASN A 167
LEU A  24
VAL A 159
ALA A 160
 None
None
None
EDO  A 309 (-3.5A)
None
 1.20A 3n23C-4r3fA:
undetectable		 3n23C-4r3fA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.31A 3n62B-4r3fA:
undetectable		 3n62B-4r3fA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 5 GLU A 181
GLN A  64
HIS A  55
GLY A  72
 None
EDO  A 303 (-2.4A)
None
None
 1.20A 3pp1A-4r3fA:
undetectable		 3pp1A-4r3fA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 5 LEU A  28
GLY A 157
PHE A 156
PHE A  40
 None
 1.17A 3smtA-4r3fA:
undetectable		 3smtA-4r3fA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 LEU A 124
MET A 126
TYR A  79
THR A  33
 None
 0.96A 3wipF-4r3fA:
undetectable
3wipJ-4r3fA:
undetectable		 3wipF-4r3fA:
20.80
3wipJ-4r3fA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 8 GLN A  42
ASN A 197
ASN A  39
THR A  36
 EDO  A 308 (-2.8A)
EDO  A 308 (-2.6A)
None
None
 1.22A 4d1yA-4r3fA:
undetectable
4d1yB-4r3fA:
undetectable		 4d1yA-4r3fA:
23.79
4d1yB-4r3fA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		4 / 7 SER A  77
ASN A 107
PHE A 108
TRP A  91
 None
 1.39A 4kcnB-4r3fA:
undetectable		 4kcnB-4r3fA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		5 / 12 ILE A 192
LEU A  45
ASP A  46
LEU A 124
VAL A  26
 EDO  A 302 (-3.8A)
EDO  A 308 ( 4.7A)
None
None
None
 1.11A 5uxdB-4r3fA:
undetectable		 5uxdB-4r3fA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		5 / 12 PHE A  54
ILE A 189
PHE A 141
PHE A 156
THR A 164
 None
 1.39A 5v5zA-4r3fA:
undetectable		 5v5zA-4r3fA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4r3f SPLICEOSOMAL PROTEIN
CWC27
(Chaetomium
thermophilum) 		5 / 12 ILE A 192
ASN A  39
PHE A  40
GLY A  66
LEU A 124
 EDO  A 302 (-3.8A)
None
None
None
None
 1.07A 6dwnC-4r3fA:
undetectable		 6dwnC-4r3fA:
16.13