SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r3i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 461
PRO A 493
PHE A 492
LEU A 491
PRO A 454
 None
 1.25A 1klmA-4r3iA:
undetectable		 1klmA-4r3iA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 455
ILE A 473
PRO A 470
PHE A 409
 None
U  B   5 ( 3.8A)
None
None
 1.17A 4fgkA-4r3iA:
undetectable		 4fgkA-4r3iA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 400
ILE A 480
LEU A 359
LEU A 461
HIS A 460
 None
None
UNX  A 607 ( 4.9A)
None
None
 1.24A 5km9B-4r3iA:
undetectable		 5km9B-4r3iA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ALA A 355
VAL A 351
PHE A 357
ILE A 448
 None
 0.99A 5of1A-4r3iA:
undetectable		 5of1A-4r3iA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ALA A 355
VAL A 351
PHE A 357
ILE A 448
 None
 0.98A 5of1B-4r3iA:
undetectable		 5of1B-4r3iA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 469
PRO A 470
LYS A 472
 UNX  A 604 ( 3.1A)
None
U  B   5 ( 2.8A)
 0.92A 5y9yA-4r3iA:
undetectable		 5y9yA-4r3iA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 448
VAL A 397
LEU A 348
THR A 486
LEU A 490
 None
 1.23A 6b54A-4r3iA:
undetectable		 6b54A-4r3iA:
22.52