SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 9 PHE A 287
TYR A 309
VAL A 268
ILE A 226
ILE A 241
 None
 1.27A 1gebA-4r3uA:
undetectable		 1gebA-4r3uA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 11 ALA A 521
LEU A 549
LEU A 517
LEU A 535
ILE A 174
 None
 0.99A 1ha2A-4r3uA:
undetectable		 1ha2A-4r3uA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
2-HYDROXYISOBUTYRYL-
COA MUTASE SMALL
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 12 ASP C  98
GLU C  99
ASP C 100
ILE A 483
ILE A 481
 None
 1.37A 1kijA-4r3uC:
undetectable		 1kijA-4r3uC:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 7 GLY A 551
ILE A 552
PRO A 214
ILE A 212
 None
 0.77A 1n49A-4r3uA:
undetectable		 1n49A-4r3uA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 6 GLY A 551
ILE A 552
PRO A 214
ILE A 212
 None
 0.87A 1n49D-4r3uA:
undetectable		 1n49D-4r3uA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 5 LEU A 535
MET A 529
LEU A 528
GLN A 516
 None
 1.21A 1p93D-4r3uA:
undetectable		 1p93D-4r3uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 8 LEU A 233
GLY A 183
LEU A 176
TYR A 236
 None
 0.82A 1s1xA-4r3uA:
undetectable		 1s1xA-4r3uA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 11 LEU A 193
ASN A 100
THR A 116
PHE A 166
GLN A 111
 None
 1.40A 1tw4A-4r3uA:
undetectable		 1tw4A-4r3uA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 10 LEU A 193
ASN A 100
THR A 116
PHE A 166
GLN A 111
 None
 1.38A 1tw4B-4r3uA:
undetectable		 1tw4B-4r3uA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 8 VAL A 299
VAL A 411
LEU A 359
PRO A 404
 None
 0.97A 2ddwA-4r3uA:
2.3		 2ddwA-4r3uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 9 ILE A 226
PHE A 281
HIS A 277
THR A 274
THR A 272
 None
 1.49A 2dttE-4r3uA:
undetectable
2dttF-4r3uA:
undetectable		 2dttE-4r3uA:
10.27
2dttF-4r3uA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 12 GLY A 138
GLY A 141
ASP A 119
THR A 122
ALA A 491
 None
5AD  A 803 ( 4.1A)
None
None
None
 1.01A 2gluA-4r3uA:
undetectable		 2gluA-4r3uA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		3 / 3 ARG A 303
GLY A  74
PRO A  75
 None
 0.67A 2hreD-4r3uA:
undetectable		 2hreD-4r3uA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 6 ARG A 493
THR A  95
ASP A 119
THR A 122
 None
 1.03A 2okcB-4r3uA:
undetectable		 2okcB-4r3uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 5 ILE A 144
LEU A 153
ASP A  98
ALA A 143
 None
 1.01A 2opxA-4r3uA:
undetectable		 2opxA-4r3uA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 12 GLY A 360
GLY A  74
LYS A 301
GLU A 298
ALA A 357
 None
 1.06A 2plwA-4r3uA:
undetectable		 2plwA-4r3uA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 8 THR A 167
GLN A 208
ASP A 117
SER A 115
 3KK  A 802 ( 3.4A)
3KK  A 802 (-3.8A)
3KK  A 802 ( 2.7A)
3HC  A 801 ( 3.5A)
 1.11A 2xytE-4r3uA:
undetectable		 2xytE-4r3uA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 8 THR A 167
GLN A 208
ASP A 117
SER A 115
 3KK  A 802 ( 3.4A)
3KK  A 802 (-3.8A)
3KK  A 802 ( 2.7A)
3HC  A 801 ( 3.5A)
 1.16A 2xz5C-4r3uA:
undetectable
2xz5D-4r3uA:
undetectable		 2xz5C-4r3uA:
17.25
2xz5D-4r3uA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 11 ILE A 168
ASN A 527
MET A 529
LEU A 175
ILE A 174
 None
 1.23A 3a50B-4r3uA:
undetectable		 3a50B-4r3uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 11 ILE A 168
ASN A 527
MET A 529
LEU A 175
ILE A 174
 None
 1.22A 3a50C-4r3uA:
undetectable		 3a50C-4r3uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 12 ILE A 168
ASN A 527
MET A 529
LEU A 175
ILE A 174
 None
 1.16A 3a50E-4r3uA:
undetectable		 3a50E-4r3uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		3 / 3 CYH A 331
HIS A 366
PHE A 288
 None
5AD  A 803 ( 4.8A)
3KK  A 802 ( 4.1A)
 1.20A 3cr4X-4r3uA:
undetectable		 3cr4X-4r3uA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 6 THR A 116
ILE A 144
LEU A 153
THR A  99
 None
 0.95A 3deuB-4r3uA:
1.5		 3deuB-4r3uA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 10 ASP A 149
ASP A  98
ILE A 495
PRO A 121
THR A 122
 None
 1.10A 3el5A-4r3uA:
undetectable		 3el5A-4r3uA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
2-HYDROXYISOBUTYRYL-
COA MUTASE SMALL
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 6 ARG A 557
GLY C  14
GLU A 140
GLU A 136
 None
None
B12  C 800 ( 3.5A)
None
 1.13A 3k9fA-4r3uA:
1.8
3k9fB-4r3uA:
1.8
3k9fD-4r3uA:
2.0		 3k9fA-4r3uA:
24.29
3k9fB-4r3uA:
24.29
3k9fD-4r3uA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		3 / 3 LYS A  35
ARG A  34
ASP A 294
 None
 1.02A 3o7wA-4r3uA:
undetectable		 3o7wA-4r3uA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		3 / 3 TYR A 486
GLY A  94
ASP A  98
 None
 0.70A 3ou6C-4r3uA:
undetectable		 3ou6C-4r3uA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE SMALL
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 7 ASP C  98
PRO C  97
GLN C  69
GLU C  99
 None
 1.13A 3s3oA-4r3uC:
undetectable		 3s3oA-4r3uC:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 6 GLN A 526
ARG A 220
GLU A 184
LEU A 528
 None
 1.00A 4ax8A-4r3uA:
undetectable		 4ax8A-4r3uA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE SMALL
SUBUNIT
(Aquincola
tertiaricarbonis) 		6 / 12 ALA C  26
ILE C 122
ARG C 127
ILE C 126
LEU C   9
VAL C   8
 None
B12  C 800 (-4.4A)
None
None
None
None
 1.44A 4azvA-4r3uC:
4.4		 4azvA-4r3uC:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 12 VAL A 268
THR A 260
ILE A 436
VAL A 219
ILE A 201
 None
 1.12A 4eb6B-4r3uA:
2.1
4eb6C-4r3uA:
undetectable		 4eb6B-4r3uA:
21.71
4eb6C-4r3uA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 5 ALA A  56
ILE A   8
LEU A  12
LYS A   9
 None
 1.12A 4g19A-4r3uA:
undetectable		 4g19A-4r3uA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 9 LEU A 264
VAL A 222
ILE A 226
ARG A 223
ILE A 239
 None
 1.07A 4kukA-4r3uA:
undetectable		 4kukA-4r3uA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 4 ILE A 226
VAL A 278
VAL A 271
ARG A 223
 None
 1.09A 4m6tA-4r3uA:
undetectable		 4m6tA-4r3uA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 8 ILE A 533
GLU A 534
ILE A 225
LEU A 528
 None
 0.93A 4mj8A-4r3uA:
undetectable		 4mj8A-4r3uA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 11 ASP A 149
ASP A  98
ILE A 495
PRO A 121
THR A 122
 None
 1.03A 4njvB-4r3uA:
undetectable		 4njvB-4r3uA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE SMALL
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 10 VAL C  59
VAL C  25
LEU C  29
GLY C  93
SER C  63
 None
B12  C 800 (-4.9A)
None
B12  C 800 (-3.4A)
B12  C 800 (-2.9A)
 1.14A 4ph9A-4r3uC:
undetectable		 4ph9A-4r3uC:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 5 LYS A 234
ARG A 235
LEU A 193
ASP A 189
 None
3HC  A 801 ( 3.5A)
None
None
 1.50A 4xdtA-4r3uA:
undetectable		 4xdtA-4r3uA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 12 ILE A 212
TYR A 213
GLY A 125
GLY A 543
LEU A 514
 None
 0.98A 5eqbA-4r3uA:
undetectable		 5eqbA-4r3uA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
2-HYDROXYISOBUTYRYL-
COA MUTASE SMALL
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 4 ALA A 207
PRO A 170
LEU C  15
HIS C  42
 None
 1.33A 5eskA-4r3uA:
undetectable		 5eskA-4r3uA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 12 ALA A 152
ILE A 201
PHE A 166
THR A 146
MET A 542
 None
 1.23A 5jlcA-4r3uA:
undetectable		 5jlcA-4r3uA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		4 / 8 THR A  99
ALA A 143
ASP A 145
SER A 128
 None
 1.04A 5l5fY-4r3uA:
undetectable
5l5fZ-4r3uA:
undetectable		 5l5fY-4r3uA:
15.25
5l5fZ-4r3uA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 10 THR A  99
GLY A 141
ALA A 143
ASP A 145
SER A 128
 None
5AD  A 803 ( 4.1A)
None
None
None
 1.44A 5l66K-4r3uA:
undetectable
5l66L-4r3uA:
undetectable		 5l66K-4r3uA:
20.82
5l66L-4r3uA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 10 THR A  99
GLY A 141
ALA A 143
ASP A 145
SER A 128
 None
5AD  A 803 ( 4.1A)
None
None
None
 1.45A 5l66Y-4r3uA:
undetectable
5l66Z-4r3uA:
undetectable		 5l66Y-4r3uA:
20.82
5l66Z-4r3uA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 11 ALA A  56
TRP A   3
TYR A 409
THR A  51
ALA A  53
 None
 1.40A 6dk1C-4r3uA:
undetectable		 6dk1C-4r3uA:
16.81