SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ASP B 112
HIS B 165
TRP B 572
ALA B 108
 None
 0.97A 1gxsA-4r3zB:
undetectable
1gxsB-4r3zB:
undetectable		 1gxsA-4r3zB:
16.82
1gxsB-4r3zB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 HIS B 237
SER B 387
ASP B 388
PHE B 337
 None
 1.04A 1ismB-4r3zB:
undetectable		 1ismB-4r3zB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP B 507
LEU B 508
HIS B 438
 None
 0.78A 1qknA-4r3zB:
undetectable		 1qknA-4r3zB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 HIS B 208
GLY B 210
GLN B 412
VAL B 444
LYS B 451
 None
 1.15A 1qu3A-4r3zB:
14.5		 1qu3A-4r3zB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 HIS B 208
GLY B 210
HIS B 211
VAL B 444
LYS B 451
 None
 1.19A 1qu3A-4r3zB:
14.5		 1qu3A-4r3zB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP B 551
LYS B 557
ARG B 560
 None
 1.20A 1ra8A-4r3zB:
undetectable		 1ra8A-4r3zB:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ASP B 388
HIS B 237
SER B 214
VAL B 408
PHE B 416
 None
 1.37A 1uobA-4r3zB:
undetectable		 1uobA-4r3zB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE B 416
ASN B 236
LEU B 319
GLY B 239
ASN B 202
 None
 1.22A 2e7fA-4r3zB:
undetectable		 2e7fA-4r3zB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 TYR B 384
GLU B 335
ASN B 236
 None
 1.03A 2y7hC-4r3zB:
undetectable		 2y7hC-4r3zB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4r3z AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A   6
ARG A  10
LYS A  14
 None
 1.06A 3kp3B-4r3zA:
undetectable		 3kp3B-4r3zA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ILE B 404
TYR B 406
GLN B 424
LEU B 235
 None
 0.74A 3ozwA-4r3zB:
4.8		 3ozwA-4r3zB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ALA B 640
ILE B 578
LEU B 178
ALA B 559
 None
 0.76A 3r9sC-4r3zB:
undetectable		 3r9sC-4r3zB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU B 224
VAL B 196
TYR B 230
LEU B 592
 None
 1.07A 4b3qA-4r3zB:
undetectable		 4b3qA-4r3zB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 PHE B 198
SER B 329
SER B 222
ASP B 650
 None
 1.36A 4qb9D-4r3zB:
0.3		 4qb9D-4r3zB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ALA B 532
ASP B 475
GLY B 469
GLU B 468
 None
 0.91A 5btdA-4r3zB:
2.2
5btdB-4r3zB:
undetectable
5btdC-4r3zB:
2.1		 5btdA-4r3zB:
23.55
5btdB-4r3zB:
18.45
5btdC-4r3zB:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ALA B 532
ASP B 475
GLY B 469
GLU B 468
 None
 0.91A 5btdA-4r3zB:
2.2
5btdC-4r3zB:
2.1
5btdD-4r3zB:
undetectable		 5btdA-4r3zB:
23.55
5btdC-4r3zB:
23.55
5btdD-4r3zB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ALA B 531
ARG B 472
GLY B 469
GLU B 468
 None
 0.92A 5btgA-4r3zB:
2.3
5btgC-4r3zB:
2.3
5btgD-4r3zB:
3.7		 5btgA-4r3zB:
23.55
5btgC-4r3zB:
23.55
5btgD-4r3zB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ALA B 532
ASP B 475
GLY B 469
GLU B 468
 None
 0.91A 5btgA-4r3zB:
2.3
5btgC-4r3zB:
2.3
5btgD-4r3zB:
3.7		 5btgA-4r3zB:
23.55
5btgC-4r3zB:
23.55
5btgD-4r3zB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 9 GLN B 412
VAL B 408
ASP B 197
ILE B 404
VAL B 436
 None
 1.20A 5v0iA-4r3zB:
undetectable		 5v0iA-4r3zB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 9 GLY B 653
LEU B 524
ILE B 216
LEU B 326
PHE B 520
 None
 0.97A 5vkqC-4r3zB:
undetectable
5vkqD-4r3zB:
undetectable		 5vkqC-4r3zB:
17.32
5vkqD-4r3zB:
17.32