SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 8 HIS A 180
PRO A 201
LYS A 172
THR A 394
 None
 1.07A 1rg9A-4r40A:
undetectable		 1rg9A-4r40A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 8 HIS A 180
PRO A 201
LYS A 172
THR A 394
 None
 1.08A 1rg9B-4r40A:
undetectable		 1rg9B-4r40A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 8 HIS A 180
PRO A 201
LYS A 172
THR A 394
 None
 1.06A 1rg9C-4r40A:
undetectable		 1rg9C-4r40A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 8 HIS A 180
PRO A 201
LYS A 172
THR A 394
 None
 1.08A 1rg9D-4r40A:
undetectable		 1rg9D-4r40A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 SER A 288
SER A 306
ASN A 269
GLN A 282
 FMT  A 502 (-3.3A)
None
None
None
 1.12A 2cmlA-4r40A:
7.6		 2cmlA-4r40A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 8 SER A 288
SER A 306
ASN A 269
GLN A 282
 FMT  A 502 (-3.3A)
None
None
None
 1.08A 2cmlB-4r40A:
7.1		 2cmlB-4r40A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 8 SER A 107
ASP A 109
SER A 111
GLN A 133
 None
 1.01A 2cmlC-4r40A:
12.8		 2cmlC-4r40A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 ASP A 338
SER A 381
SER A 427
ASP A 210
 None
 1.22A 3bc9A-4r40A:
undetectable		 3bc9A-4r40A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 VAL A 170
LYS A 422
GLU A 200
PRO A 201
 None
 1.09A 3hs4A-4r40A:
undetectable		 3hs4A-4r40A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		3 / 3 ASP A 210
PHE A 251
SER A 427
 None
 0.99A 3i5uB-4r40A:
undetectable		 3i5uB-4r40A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 TYR A 169
VAL A 171
VAL A 400
GLY A 419
 None
 0.92A 3kmoB-4r40A:
undetectable		 3kmoB-4r40A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 ASN A 385
ALA A 383
TYR A 187
ARG A 166
 None
 1.06A 3twpB-4r40A:
3.4		 3twpB-4r40A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 ASN A 385
ALA A 383
TYR A 187
ARG A 166
 None
 0.93A 3twpC-4r40A:
3.3		 3twpC-4r40A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		5 / 12 ARG A 237
SER A 208
VAL A 195
HIS A 196
LEU A 202
 None
 1.42A 3vt7A-4r40A:
undetectable		 3vt7A-4r40A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 ALA A 259
PRO A 249
LEU A 270
LEU A 302
 None
 1.08A 4iomA-4r40A:
undetectable		 4iomA-4r40A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 HIS A 180
PRO A 201
SER A 392
PHE A 423
 None
 1.28A 4ndnC-4r40A:
undetectable		 4ndnC-4r40A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 HIS A 180
PRO A 201
SER A 392
PHE A 423
 None
 1.26A 4odjA-4r40A:
undetectable		 4odjA-4r40A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 HIS A 180
PRO A 201
SER A 392
PHE A 423
 None
 1.28A 5a1iA-4r40A:
undetectable		 5a1iA-4r40A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 5 MET A 203
SER A 204
GLY A 247
ALA A 248
 None
 0.87A 5k50A-4r40A:
2.7		 5k50A-4r40A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 7 HIS A 180
PRO A 201
SER A 392
PHE A 423
 None
 1.29A 6g6rA-4r40A:
undetectable		 6g6rA-4r40A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 5 ALA A 215
TYR A 216
GLN A 238
ILE A 236
 None
 1.22A 6g9bA-4r40A:
undetectable
6g9bB-4r40A:
undetectable		 6g9bA-4r40A:
13.66
6g9bB-4r40A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r40 PROTEIN TOLB
(Yersinia
pestis) 		4 / 6 ILE A  25
LEU A 414
MET A 388
THR A 387
 None
 1.02A 6nmfN-4r40A:
undetectable
6nmfW-4r40A:
undetectable		 6nmfN-4r40A:
22.91
6nmfW-4r40A:
8.31