SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r42'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 7 HIS A  79
LEU A 156
THR A 152
THR A 155
 None
 1.08A 1am6A-4r42A:
undetectable		 1am6A-4r42A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 7 GLU A  64
LEU A 159
GLU A  35
MET A  71
 None
None
MN  A 301 (-2.0A)
None
 1.15A 1linA-4r42A:
undetectable		 1linA-4r42A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 ALA A 134
ALA A 136
VAL A  72
LEU A  75
LEU A 156
 None
 1.13A 1rlbF-4r42A:
undetectable		 1rlbF-4r42A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 GLU A 163
HIS A 166
GLU A  35
ILE A  61
GLU A  65
 MN  A 301 ( 2.2A)
MN  A 302 (-3.4A)
MN  A 301 (-2.0A)
None
MN  A 302 ( 2.5A)
 0.94A 1rnrA-4r42A:
9.4		 1rnrA-4r42A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 LEU A 159
GLU A  35
SER A 165
ILE A  61
GLU A  65
 None
MN  A 301 (-2.0A)
None
None
MN  A 302 ( 2.5A)
 1.39A 1rnrA-4r42A:
9.4		 1rnrA-4r42A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLU A 163
HIS A 166
GLU A  35
ILE A  61
GLU A  65
 MN  A 301 ( 2.2A)
MN  A 302 (-3.4A)
MN  A 301 (-2.0A)
None
MN  A 302 ( 2.5A)
 0.90A 1rnrB-4r42A:
6.9		 1rnrB-4r42A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 8 HIS A 166
GLU A 163
HIS A  68
ALA A 136
 MN  A 302 (-3.4A)
MN  A 301 ( 2.2A)
MN  A 301 (-3.3A)
None
 1.00A 2bnnA-4r42A:
undetectable
2bnnB-4r42A:
undetectable		 2bnnA-4r42A:
23.11
2bnnB-4r42A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 TYR A 115
GLY A  31
LEU A  36
GLU A  27
 None
 1.01A 3ps9A-4r42A:
undetectable		 3ps9A-4r42A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLY A  31
GLU A  27
GLY A  73
HIS A  68
GLU A  65
 None
None
None
MN  A 301 (-3.3A)
MN  A 302 ( 2.5A)
 1.28A 4jlgA-4r42A:
undetectable		 4jlgA-4r42A:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLY A 135
LEU A  69
PHE A 103
LEU A  40
THR A  33
 None
 1.21A 4ze1A-4r42A:
undetectable		 4ze1A-4r42A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 LEU A 174
VAL A 122
ASP A 121
 None
 0.66A 5x23A-4r42A:
undetectable		 5x23A-4r42A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 8 GLU A   7
HIS A   4
PHE A  66
LEU A  40
 None
 0.93A 5y2tB-4r42A:
undetectable		 5y2tB-4r42A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4r42 ALR3090 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 7 HIS A   4
HIS A  10
GLU A  70
GLU A  77
 None
 1.20A 6mn4F-4r42A:
undetectable		 6mn4F-4r42A:
20.96