SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		5 / 9 ILE A 250
LEU A 186
GLU A 349
ALA A 350
VAL A 268
 None
 1.30A 1ctrA-4r4gA:
undetectable		 1ctrA-4r4gA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		3 / 3 ARG A 279
SER A 289
TYR A 288
 None
 0.78A 1x70A-4r4gA:
undetectable		 1x70A-4r4gA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		5 / 12 PHE A 187
LEU A 347
PHE A 351
ALA A 175
ILE A 197
 None
 1.08A 3nxuA-4r4gA:
undetectable		 3nxuA-4r4gA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		5 / 12 PHE A 187
LEU A 347
PHE A 351
ALA A 175
ILE A 197
 None
 1.05A 3nxuB-4r4gA:
undetectable		 3nxuB-4r4gA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 8 LEU A  83
ALA A  43
SER A  40
TYR A 140
 None
 0.92A 3rodA-4r4gA:
undetectable		 3rodA-4r4gA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 7 SER A 179
ILE A 250
THR A 254
THR A 255
 None
None
None
PG4  A 402 (-4.2A)
 1.08A 3tneB-4r4gA:
undetectable		 3tneB-4r4gA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 7 GLU A 354
ILE A 352
TYR A 307
VAL A 284
 None
 1.11A 4a97A-4r4gA:
3.4		 4a97A-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 7 GLU A 354
ILE A 352
TYR A 307
VAL A 300
 None
 1.06A 4a97A-4r4gA:
3.4		 4a97A-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 7 GLU A 354
ILE A 352
TYR A 307
VAL A 284
 None
 1.11A 4a97D-4r4gA:
undetectable		 4a97D-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 7 GLU A 354
ILE A 352
TYR A 307
VAL A 300
 None
 0.84A 4a97D-4r4gA:
undetectable		 4a97D-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 7 GLU A 354
ILE A 352
TYR A 307
VAL A 300
 None
 1.07A 4a97H-4r4gA:
undetectable		 4a97H-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 6 GLU A 354
ILE A 352
TYR A 307
VAL A 284
 None
 1.13A 4a97I-4r4gA:
3.4		 4a97I-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 6 GLU A 354
ILE A 352
TYR A 307
VAL A 300
 None
 0.95A 4a97I-4r4gA:
3.4		 4a97I-4r4gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 5 LYS A 313
LEU A 314
GLU A 310
LEU A 276
 None
 1.33A 4k4yI-4r4gA:
undetectable		 4k4yI-4r4gA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 6 ASP A 234
ASN A 235
ALA A 232
ASP A 229
 None
 1.19A 4mdbA-4r4gA:
undetectable		 4mdbA-4r4gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4r4g PUTATIVE LIPOPROTEIN
YCDA
(Bacillus
subtilis) 		4 / 5 VAL A  75
VAL A  73
GLY A 124
PHE A  90
 None
 1.02A 5d4nA-4r4gA:
undetectable
5d4nC-4r4gA:
undetectable		 5d4nA-4r4gA:
20.52
5d4nC-4r4gA:
20.52