SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4r4h HIV-1 ENV GP120
(Human
immunodeficiency
virus
1) 		5 / 12 THR A 454
GLY A 471
GLY A 473
GLN A 258
THR A 257
 None
 1.33A 2azxA-4r4hA:
undetectable		 2azxA-4r4hA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4r4h HIV-1 ENV GP120
(Human
immunodeficiency
virus
1) 		4 / 4 SER A 392
TRP A 338
ASP A 269
ILE A 270
 None
 1.38A 2oxtD-4r4hA:
undetectable		 2oxtD-4r4hA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 4r4h HIV-1 ENV GP120
(Human
immunodeficiency
virus
1) 		3 / 3 SER A 374
PHE A 381
LYS A 420
 None
 0.99A 3u88A-4r4hA:
undetectable		 3u88A-4r4hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4r4h HIV-1 ENV GP120
(Human
immunodeficiency
virus
1) 		4 / 8 LYS A 404
ASN A 395
THR A 393
TRP A 394
 None
 1.25A 4d1yA-4r4hA:
undetectable
4d1yB-4r4hA:
undetectable		 4d1yA-4r4hA:
19.31
4d1yB-4r4hA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4r4h HIV-1 ENV GP120
(Human
immunodeficiency
virus
1) 		4 / 6 ASP A  57
PRO A 214
HIS A 216
ARG A 252
 None
None
None
NAG  A 601 ( 4.9A)
 0.69A 4lajA-4r4hA:
47.6
4lajB-4r4hA:
19.8		 4lajA-4r4hA:
75.18
4lajB-4r4hA:
75.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4r4h HIV-1 ENV GP120
(Human
immunodeficiency
virus
1) 		4 / 7 ILE A 345
PHE A 360
LEU A 349
THR A 283
 None
 1.11A 4mmcA-4r4hA:
undetectable		 4mmcA-4r4hA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4r4h HIV-1 ENV GP120
(Human
immunodeficiency
virus
1) 		4 / 6 PHE A 468
LEU A 451
ARG A 469
GLY A 471
 None
None
NAG  A 606 ( 4.7A)
None
 1.06A 5o4yA-4r4hA:
undetectable		 5o4yA-4r4hA:
2.29