SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4r4n HIV-1 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 THR A 373
ILE A 424
ILE A 423
GLU A 381
ALA A 329
 None
 1.22A 1jtxA-4r4nA:
undetectable		 1jtxA-4r4nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4r4n HIV-1 GP120
(Human
immunodeficiency
virus
1) 		5 / 9 THR A 387
LEU A 416
VAL A 333
ILE A 449
VAL A 292
 None
 1.38A 2l8mA-4r4nA:
undetectable		 2l8mA-4r4nA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4r4n HIV-1 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 GLY A 458
GLU A 466
GLY A 460
ASN A 280
 None
 1.03A 3e9rA-4r4nA:
undetectable		 3e9rA-4r4nA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4r4n HIV-1 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 GLY A 458
GLU A 466
GLY A 460
ASN A 280
 None
 1.03A 3e9rC-4r4nA:
undetectable		 3e9rC-4r4nA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4r4n HIV-1 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ASN A 262
SER A 447
GLU A 211
GLY A 380
ILE A 443
 NAG  A 501 (-1.8A)
NAG  A 501 (-2.8A)
NAG  A 501 (-2.7A)
None
None
 1.40A 3jb2A-4r4nA:
undetectable		 3jb2A-4r4nA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4r4n HIV-1 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 GLN A 203
ASP A 113
GLN A 428
 None
 0.84A 4aztA-4r4nA:
undetectable		 4aztA-4r4nA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 4r4n HIV-1 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 LEU A 288
PHE A 361
VAL A 286
TRP A 338
PHE A 391
 None
 1.25A 4c9wA-4r4nA:
undetectable		 4c9wA-4r4nA:
16.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4r4n HIV-1 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 ASP A  57
PRO A 214
HIS A 216
ARG A 252
 None
None
None
NAG  A 501 (-3.1A)
 0.55A 4lajA-4r4nA:
45.5
4lajB-4r4nA:
45.6		 4lajA-4r4nA:
75.20
4lajB-4r4nA:
75.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4r4n HIV-1 GP120
(Human
immunodeficiency
virus
1) 		5 / 9 SER A 334
GLY A 335
SER A 336
GLY A 412
THR A 413
 None
 0.77A 4lb0A-4r4nA:
undetectable		 4lb0A-4r4nA:
22.66