SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 5 LEU A 534
GLU A 538
ALA A 419
LEU A 421
 None
 1.11A 1eta2-4r4zA:
undetectable		 1eta2-4r4zA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		5 / 12 ASN A 468
ILE A 308
GLY A 307
THR A 326
ASP A 243
 None
 1.12A 1likA-4r4zA:
undetectable		 1likA-4r4zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 6 PHE A 306
PHE A 311
ASN A 312
GLN A 238
 None
 1.20A 1t9uA-4r4zA:
undetectable		 1t9uA-4r4zA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 6 PHE A 311
ASN A 312
ASN A 352
GLN A 238
 None
 1.35A 1t9uA-4r4zA:
undetectable		 1t9uA-4r4zA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		3 / 3 LEU A 483
PHE A 437
ARG A 247
 None
 0.80A 1xdkF-4r4zA:
undetectable		 1xdkF-4r4zA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 7 SER A 471
SER A 481
SER A 479
ASN A 473
 None
 1.07A 2cmlA-4r4zA:
undetectable		 2cmlA-4r4zA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 8 SER A 471
SER A 481
SER A 479
ASN A 473
 None
 1.06A 2cmlB-4r4zA:
undetectable		 2cmlB-4r4zA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 8 SER A 471
SER A 481
SER A 479
ASN A 473
 None
 1.09A 2cmlC-4r4zA:
undetectable		 2cmlC-4r4zA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 8 SER A 471
SER A 481
SER A 479
ASN A 473
 None
 1.05A 2cmlD-4r4zA:
undetectable		 2cmlD-4r4zA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 8 THR A 138
GLY A 129
THR A 104
ILE A 111
 None
 0.67A 2f9wA-4r4zA:
undetectable
2f9wB-4r4zA:
undetectable		 2f9wA-4r4zA:
19.35
2f9wB-4r4zA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		5 / 12 PHE A 252
SER A 261
LEU A 273
MET A 389
LEU A 218
 None
 1.46A 2prgB-4r4zA:
undetectable		 2prgB-4r4zA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 8 ILE A 196
HIS A 358
PHE A 349
GLY A 351
 None
 0.98A 2vdbA-4r4zA:
undetectable		 2vdbA-4r4zA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		5 / 12 ARG A 465
PHE A 303
GLY A 491
ILE A 493
THR A 326
 None
 1.47A 3a25A-4r4zA:
undetectable		 3a25A-4r4zA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 7 PHE A  65
ASP A 159
ILE A 168
TYR A 176
 None
 1.06A 3p6hA-4r4zA:
undetectable		 3p6hA-4r4zA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 5 ASP A 435
SER A 526
SER A 524
GLY A 518
 None
 1.08A 3rxhA-4r4zA:
undetectable		 3rxhA-4r4zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		5 / 12 ASP A 354
ILE A 315
GLY A 309
SER A 240
ALA A 244
 None
 0.91A 3sufD-4r4zA:
undetectable		 3sufD-4r4zA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 8 PHE A  65
PHE A  46
ALA A  44
PHE A  48
 None
 0.94A 3t3sD-4r4zA:
undetectable		 3t3sD-4r4zA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 6 GLU A 298
PHE A 349
VAL A 270
PHE A 296
 None
 1.17A 4a97E-4r4zA:
undetectable		 4a97E-4r4zA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 7 GLY A 351
ASP A 250
GLY A 249
VAL A 388
 None
 0.90A 4c5nA-4r4zA:
undetectable		 4c5nA-4r4zA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 8 SER A 361
ARG A 210
ILE A 360
GLU A 192
 None
 1.22A 4cx7C-4r4zA:
undetectable
4cx7D-4r4zA:
undetectable		 4cx7C-4r4zA:
20.62
4cx7D-4r4zA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 7 GLY A 265
ILE A 216
LEU A 218
PHE A 252
 None
 0.90A 4ejjD-4r4zA:
undetectable		 4ejjD-4r4zA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		3 / 3 ASP A 482
ARG A 465
ASP A 460
 None
 0.74A 4fp9A-4r4zA:
undetectable		 4fp9A-4r4zA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		3 / 3 ASP A 482
ARG A 465
ASP A 460
 None
 0.78A 4fp9F-4r4zA:
undetectable		 4fp9F-4r4zA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 7 TYR A   8
GLY A 123
SER A  25
LEU A  34
 None
 1.10A 5bphB-4r4zA:
undetectable		 5bphB-4r4zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		3 / 3 LEU A 134
TYR A   8
SER A  25
 None
 0.83A 5iktA-4r4zA:
undetectable		 5iktA-4r4zA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		4 / 6 GLY A 214
THR A 215
ASN A 197
LYS A 355
 None
 1.02A 5xxiA-4r4zA:
undetectable		 5xxiA-4r4zA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		5 / 12 LEU A 339
ILE A 223
GLY A 341
ILE A 253
ILE A 344
 None
 1.01A 6emuB-4r4zA:
undetectable		 6emuB-4r4zA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		5 / 12 LEU A 339
ILE A 223
GLY A 341
ILE A 253
ILE A 344
 None
 1.02A 6emuC-4r4zA:
undetectable		 6emuC-4r4zA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r4z PNGF-II
(Elizabethkingia
meningoseptica) 		3 / 3 ARG A 258
LEU A 289
PHE A 383
 None
 0.61A 6nknP-4r4zA:
undetectable		 6nknP-4r4zA:
17.16