SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4r58 LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 8 HIS A 176
THR A 133
HIS A 154
THR A 155
 None
 0.87A 1gtfN-4r58A:
undetectable
1gtfO-4r58A:
undetectable		 1gtfN-4r58A:
15.91
1gtfO-4r58A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4r58 LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 180
ASN A 183
THR A 142
ILE A 141
SER A 145
 None
 1.41A 1xlxA-4r58A:
undetectable		 1xlxA-4r58A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4r58 LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 202
ASN A 205
THR A 164
ILE A 163
SER A 167
 None
 1.44A 1xlxA-4r58A:
undetectable		 1xlxA-4r58A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4r58 LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 8 ILE A  22
PHE A  18
THR A  67
LEU A  65
 None
 0.94A 2eikN-4r58A:
undetectable
2eikW-4r58A:
undetectable		 2eikN-4r58A:
18.29
2eikW-4r58A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 4r58 LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		3 / 3 GLU A 198
LYS A 220
ASN A 218
 None
 1.01A 4y1dA-4r58A:
undetectable
4y1dD-4r58A:
undetectable		 4y1dA-4r58A:
19.56
4y1dD-4r58A:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4r58 LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 8 HIS A 176
THR A 133
HIS A 154
THR A 155
 None
 0.88A 5eezL-4r58A:
undetectable
5eezV-4r58A:
undetectable		 5eezL-4r58A:
15.91
5eezV-4r58A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4r58 LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 8 HIS A 176
THR A 133
HIS A 154
THR A 155
 None
 0.88A 5ef1L-4r58A:
undetectable
5ef1V-4r58A:
undetectable		 5ef1L-4r58A:
15.91
5ef1V-4r58A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4r58 LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 8 HIS A 176
THR A 133
HIS A 154
THR A 155
 None
 0.88A 5ef2L-4r58A:
undetectable
5ef2V-4r58A:
undetectable		 5ef2L-4r58A:
15.91
5ef2V-4r58A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4r58 LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A  26
LEU A  62
PRO A  63
PHE A  13
THR A   7
 None
 1.28A 6debB-4r58A:
undetectable		 6debB-4r58A:
15.45