SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A  83
LEU A  74
LEU A  89
LEU A  91
LEU A 107
 None
 1.26A 1mx1C-4r5cA:
undetectable		 1mx1C-4r5cA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 9 LEU A 139
LEU A 123
VAL A 103
LEU A 110
PHE A 128
 None
 1.28A 1tbfA-4r5cA:
undetectable		 1tbfA-4r5cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 9 LEU A 163
LEU A 147
VAL A 127
LEU A 134
PHE A 152
 None
 1.27A 1tbfA-4r5cA:
undetectable		 1tbfA-4r5cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 9 LEU A 187
LEU A 171
VAL A 151
LEU A 158
PHE A 176
 None
 1.21A 1tbfA-4r5cA:
undetectable		 1tbfA-4r5cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 9 LEU A 211
LEU A 195
VAL A 175
LEU A 182
PHE A 200
 None
 1.28A 1tbfA-4r5cA:
undetectable		 1tbfA-4r5cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 6 ALA A 221
PHE A 200
ILE A 216
ASP A 218
 None
None
None
EDO  A 401 (-3.9A)
 1.04A 1yc2A-4r5cA:
undetectable		 1yc2A-4r5cA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 6 ASN A  63
ASN A  40
ILE A   2
GLN A  36
 None
 1.26A 2hkkA-4r5cA:
undetectable		 2hkkA-4r5cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 PHE A 200
ILE A 216
ALA A 221
LEU A 192
LEU A 161
 None
 1.30A 2rctA-4r5cA:
undetectable		 2rctA-4r5cA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 ILE A 216
ASN A 162
LEU A 195
ALA A 221
LEU A 231
 None
 0.94A 3a50A-4r5cA:
undetectable		 3a50A-4r5cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 11 ILE A 216
LEU A 185
ASN A 162
LEU A 195
LEU A 231
 None
 1.00A 3a50C-4r5cA:
undetectable		 3a50C-4r5cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 ILE A 216
LEU A 185
ASN A 162
LEU A 195
LEU A 231
 None
 1.07A 3a50E-4r5cA:
undetectable		 3a50E-4r5cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 PHE A 200
ILE A 216
ALA A 221
LEU A 192
LEU A 161
 None
 1.24A 4qynA-4r5cA:
undetectable		 4qynA-4r5cA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 PHE A 200
ILE A 216
LEU A 192
LEU A 161
LEU A 185
 None
 1.43A 4qynB-4r5cA:
undetectable		 4qynB-4r5cA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 PHE A 200
ILE A 216
ALA A 221
LEU A 192
LEU A 185
 None
 1.31A 4qzuA-4r5cA:
undetectable		 4qzuA-4r5cA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 4 ASN A  72
VAL A  55
THR A  20
ILE A  21
 None
 1.39A 4retA-4r5cA:
undetectable		 4retA-4r5cA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 4 ASN A  72
VAL A  55
THR A  20
ILE A  21
 None
 1.39A 4retC-4r5cA:
undetectable		 4retC-4r5cA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 147
LEU A 192
ASN A 186
THR A 184
VAL A 199
 None
 1.16A 4x1kD-4r5cA:
undetectable		 4x1kD-4r5cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 147
LEU A 192
ASN A 186
THR A 184
VAL A 199
 None
 1.06A 4x1yD-4r5cA:
undetectable		 4x1yD-4r5cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 11 LEU A 147
LEU A 192
ASN A 186
THR A 184
VAL A 199
 None
 1.13A 4x20D-4r5cA:
undetectable		 4x20D-4r5cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 5 PHE A  17
ILE A  42
GLY A  57
ILE A  45
 None
 0.84A 5dzkB-4r5cA:
undetectable
5dzkI-4r5cA:
undetectable
5dzkW-4r5cA:
undetectable		 5dzkB-4r5cA:
21.71
5dzkI-4r5cA:
17.94
5dzkW-4r5cA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A  25
LEU A  61
PRO A  62
PHE A  12
THR A   6
 None
 1.24A 6debB-4r5cA:
undetectable		 6debB-4r5cA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4r5c LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 ASN A 118
ASN A 142
LEU A 115
ASN A 114
GLY A  71
 None
 1.12A 6dwnA-4r5cA:
undetectable		 6dwnA-4r5cA:
11.51