SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 4 ALA A   0
GLN A  36
TYR A  60
LEU A  83
 None
 1.47A 1e6wC-4r5dA:
undetectable		 1e6wC-4r5dA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 137
LEU A 113
LEU A  89
LEU A 123
LEU A 120
 None
 1.09A 1sqnB-4r5dA:
undetectable		 1sqnB-4r5dA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 209
LEU A 185
LEU A 161
LEU A 195
LEU A 192
 None
 1.05A 1sqnB-4r5dA:
undetectable		 1sqnB-4r5dA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 233
LEU A 209
LEU A 185
LEU A 219
LEU A 216
 None
 1.13A 1sqnB-4r5dA:
undetectable		 1sqnB-4r5dA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 9 LEU A 139
LEU A 123
VAL A 103
LEU A 110
PHE A 128
 None
 1.28A 1tbfA-4r5dA:
undetectable		 1tbfA-4r5dA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 9 LEU A 163
LEU A 147
VAL A 127
LEU A 134
PHE A 152
 None
 1.22A 1tbfA-4r5dA:
undetectable		 1tbfA-4r5dA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 9 LEU A 187
LEU A 171
VAL A 151
LEU A 158
PHE A 176
 None
 1.23A 1tbfA-4r5dA:
undetectable		 1tbfA-4r5dA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 9 LEU A 211
LEU A 195
VAL A 175
LEU A 182
PHE A 200
 None
 1.26A 1tbfA-4r5dA:
undetectable		 1tbfA-4r5dA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		3 / 3 GLY A 326
GLU A 328
ASN A 353
 None
 0.64A 1zq9A-4r5dA:
undetectable		 1zq9A-4r5dA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 ILE A 362
ALA A 363
LEU A 394
LEU A 406
ILE A 419
 None
 1.07A 2h77A-4r5dA:
undetectable		 2h77A-4r5dA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 6 ASN A  63
ASN A  40
ILE A   2
GLN A  36
 None
 1.21A 2hkkA-4r5dA:
undetectable		 2hkkA-4r5dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 ILE A 325
LEU A 349
LEU A 309
ILE A 305
ALA A 301
 None
 0.89A 3a50D-4r5dA:
undetectable		 3a50D-4r5dA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 ILE A 382
LEU A 406
LEU A 366
ILE A 362
ALA A 358
 None
 1.05A 3a50D-4r5dA:
undetectable		 3a50D-4r5dA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 390
ILE A 382
CYH A 409
LEU A 377
ASP A 405
 None
 0.97A 3ko0A-4r5dA:
undetectable
3ko0B-4r5dA:
undetectable
3ko0C-4r5dA:
undetectable
3ko0D-4r5dA:
undetectable		 3ko0A-4r5dA:
10.93
3ko0B-4r5dA:
10.93
3ko0C-4r5dA:
10.93
3ko0D-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 390
ILE A 382
CYH A 409
LEU A 377
ASP A 405
 None
 1.00A 3ko0G-4r5dA:
undetectable
3ko0H-4r5dA:
undetectable
3ko0I-4r5dA:
undetectable
3ko0J-4r5dA:
undetectable		 3ko0G-4r5dA:
10.93
3ko0H-4r5dA:
10.93
3ko0I-4r5dA:
10.93
3ko0J-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 11 LEU A 377
ASP A 405
LEU A 390
ILE A 382
CYH A 409
 None
 0.96A 3ko0A-4r5dA:
undetectable
3ko0B-4r5dA:
undetectable
3ko0I-4r5dA:
undetectable
3ko0J-4r5dA:
undetectable		 3ko0A-4r5dA:
10.93
3ko0B-4r5dA:
10.93
3ko0I-4r5dA:
10.93
3ko0J-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 390
ILE A 382
CYH A 409
LEU A 377
ASP A 405
 None
 0.94A 3ko0K-4r5dA:
undetectable
3ko0L-4r5dA:
undetectable
3ko0S-4r5dA:
undetectable
3ko0T-4r5dA:
undetectable		 3ko0K-4r5dA:
10.93
3ko0L-4r5dA:
10.93
3ko0S-4r5dA:
10.93
3ko0T-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 377
ASP A 405
LEU A 390
ILE A 382
CYH A 409
 None
 0.98A 3ko0K-4r5dA:
undetectable
3ko0L-4r5dA:
undetectable
3ko0M-4r5dA:
undetectable
3ko0N-4r5dA:
undetectable		 3ko0K-4r5dA:
10.93
3ko0L-4r5dA:
10.93
3ko0M-4r5dA:
10.93
3ko0N-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 390
ILE A 382
CYH A 409
LEU A 377
ASP A 405
 None
 1.00A 3ko0M-4r5dA:
undetectable
3ko0N-4r5dA:
undetectable
3ko0O-4r5dA:
undetectable
3ko0P-4r5dA:
undetectable		 3ko0M-4r5dA:
10.93
3ko0N-4r5dA:
10.93
3ko0O-4r5dA:
10.93
3ko0P-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A 377
ASP A 405
LEU A 390
ILE A 382
CYH A 409
 None
 0.95A 3ko0M-4r5dA:
undetectable
3ko0N-4r5dA:
undetectable
3ko0O-4r5dA:
undetectable
3ko0P-4r5dA:
undetectable		 3ko0M-4r5dA:
10.93
3ko0N-4r5dA:
10.93
3ko0O-4r5dA:
10.93
3ko0P-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 4 ASN A  72
VAL A  55
THR A  20
ILE A  21
 None
 1.41A 4retA-4r5dA:
undetectable		 4retA-4r5dA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 4 ASN A  72
VAL A  55
THR A  20
ILE A  21
 None
 1.41A 4retC-4r5dA:
undetectable		 4retC-4r5dA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		4 / 7 GLU A 300
ILE A 325
LEU A 344
ILE A 305
 None
 0.85A 4xumA-4r5dA:
undetectable		 4xumA-4r5dA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		3 / 3 ASN A 322
SER A 293
SER A 264
 EDO  A 506 (-3.8A)
None
None
 0.71A 5gsnA-4r5dA:
undetectable		 5gsnA-4r5dA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		3 / 3 ASN A 436
SER A 407
SER A 378
 None
SO4  A 505 ( 3.9A)
None
 0.73A 5gsnA-4r5dA:
undetectable		 5gsnA-4r5dA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 LEU A  25
LEU A  61
PRO A  62
PHE A  12
THR A   6
 None
 1.23A 6debB-4r5dA:
undetectable		 6debB-4r5dA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 12 ASN A 118
ASN A 142
LEU A 115
ASN A 114
GLY A  71
 None
 1.10A 6dwnA-4r5dA:
undetectable		 6dwnA-4r5dA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4r5d LEUCINE RICH REPEAT
PROTEIN
(synthetic
construct) 		5 / 10 VAL A 248
ALA A 247
LEU A 276
LEU A 240
LEU A 263
 None
 0.97A 6f5uA-4r5dA:
undetectable
6f5uB-4r5dA:
undetectable		 6f5uA-4r5dA:
11.98
6f5uB-4r5dA:
9.82