SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A 330
VAL A 309
ILE A 251
VAL A 322
ILE A 324
 None
 0.76A 1hsgA-4r5oA:
undetectable		 1hsgA-4r5oA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 330
VAL A 309
ILE A 251
VAL A 322
ILE A 324
 None
 0.72A 1ohrB-4r5oA:
undetectable		 1ohrB-4r5oA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A  76
TYR A 197
SER A 150
 ACT  A 504 ( 3.8A)
None
None
 0.92A 2gvcB-4r5oA:
undetectable		 2gvcB-4r5oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A  76
TYR A 197
SER A 150
 ACT  A 504 ( 3.8A)
None
None
 0.93A 2gvcE-4r5oA:
undetectable		 2gvcE-4r5oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A 114
ASP A  97
SER A  48
VAL A  50
 7PE  A 502 ( 3.7A)
7PE  A 502 (-3.5A)
7PE  A 502 ( 4.5A)
None
 0.99A 2hdnE-4r5oA:
undetectable
2hdnF-4r5oA:
undetectable
2hdnH-4r5oA:
undetectable		 2hdnE-4r5oA:
8.04
2hdnF-4r5oA:
22.39
2hdnH-4r5oA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A  48
VAL A  50
SER A 114
ASP A  97
 7PE  A 502 ( 4.5A)
None
7PE  A 502 ( 3.7A)
7PE  A 502 (-3.5A)
 1.00A 2hdnF-4r5oA:
undetectable
2hdnG-4r5oA:
undetectable
2hdnH-4r5oA:
undetectable		 2hdnF-4r5oA:
22.39
2hdnG-4r5oA:
8.04
2hdnH-4r5oA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 SER A 114
ASP A  97
SER A  48
VAL A  50
 7PE  A 502 ( 3.7A)
7PE  A 502 (-3.5A)
7PE  A 502 ( 4.5A)
None
 0.98A 2hdnI-4r5oA:
undetectable
2hdnJ-4r5oA:
undetectable
2hdnL-4r5oA:
undetectable		 2hdnI-4r5oA:
8.04
2hdnJ-4r5oA:
22.39
2hdnL-4r5oA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 SER A  48
VAL A  50
SER A 114
ASP A  97
 7PE  A 502 ( 4.5A)
None
7PE  A 502 ( 3.7A)
7PE  A 502 (-3.5A)
 1.03A 2hdnJ-4r5oA:
undetectable
2hdnK-4r5oA:
undetectable
2hdnL-4r5oA:
undetectable		 2hdnJ-4r5oA:
22.39
2hdnK-4r5oA:
8.04
2hdnL-4r5oA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A 138
ASN A 448
PHE A 446
GLN A 403
 None
 1.27A 2jc9A-4r5oA:
undetectable		 2jc9A-4r5oA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 271
SER A 259
GLN A 295
ILE A 293
 None
 1.08A 2xz5B-4r5oA:
undetectable
2xz5E-4r5oA:
undetectable		 2xz5B-4r5oA:
18.33
2xz5E-4r5oA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 GLN A  49
ILE A  90
SER A  48
CYH A  94
 None
None
7PE  A 502 ( 4.5A)
None
 1.35A 2xz5D-4r5oA:
undetectable
2xz5E-4r5oA:
undetectable		 2xz5D-4r5oA:
18.33
2xz5E-4r5oA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 389
ASP A 367
TYR A 371
 None
 0.86A 2yvlB-4r5oA:
undetectable		 2yvlB-4r5oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 ILE A 360
ILE A 361
GLY A 351
PRO A 339
LEU A 407
 None
None
7PE  A 503 ( 3.8A)
None
None
 1.42A 3elzB-4r5oA:
undetectable		 3elzB-4r5oA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A 330
VAL A 309
ILE A 251
VAL A 322
ILE A 324
 None
 0.79A 3em3B-4r5oA:
undetectable		 3em3B-4r5oA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 330
VAL A 309
ILE A 251
VAL A 322
ILE A 324
 None
 0.93A 3em6B-4r5oA:
undetectable		 3em6B-4r5oA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 159
GLY A 131
SER A 439
ASN A 161
 ACT  A 505 (-4.9A)
ACT  A 505 (-3.9A)
None
ACT  A 505 (-4.0A)
 0.94A 3lslA-4r5oA:
undetectable
3lslD-4r5oA:
undetectable		 3lslA-4r5oA:
21.28
3lslD-4r5oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 330
VAL A 309
ILE A 251
VAL A 322
ILE A 324
 None
 0.83A 4dqfA-4r5oA:
undetectable		 4dqfA-4r5oA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 363
VAL A 302
TYR A 373
LEU A 312
 None
 1.14A 4q0bA-4r5oA:
undetectable		 4q0bA-4r5oA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 168
PHE A 188
LEU A 211
LEU A 231
 None
 0.93A 4qopC-4r5oA:
undetectable		 4qopC-4r5oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 PRO A 348
LEU A 398
SER A 442
 None
 0.71A 5fsaB-4r5oA:
undetectable		 5fsaB-4r5oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ARG A 227
GLY A 225
TYR A 248
ASN A 166
LEU A 177
 None
None
7PE  A 503 (-4.6A)
7PE  A 503 (-4.3A)
None
 1.36A 5lsuA-4r5oA:
undetectable		 5lsuA-4r5oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ARG A 227
GLY A 225
TYR A 248
ASN A 166
LEU A 177
 None
None
7PE  A 503 (-4.6A)
7PE  A 503 (-4.3A)
None
 1.26A 5lsuB-4r5oA:
undetectable		 5lsuB-4r5oA:
20.98