SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY
(Pyrobaculum
calidifontis) 		4 / 6 ASP A 123
LEU A 124
VAL A 125
ILE A 126
 MG  A 301 (-2.6A)
None
None
None
 1.03A 1s9qA-4r5qA:
undetectable		 1s9qA-4r5qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY
(Pyrobaculum
calidifontis) 		5 / 12 ILE A 133
TYR A  97
LEU A 101
VAL A 107
LEU A   3
 None
 1.19A 2bxfA-4r5qA:
undetectable		 2bxfA-4r5qA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY
(Pyrobaculum
calidifontis) 		5 / 12 ILE A 133
TYR A  97
LEU A 101
VAL A 107
LEU A   3
 None
 1.18A 2bxfB-4r5qA:
undetectable		 2bxfB-4r5qA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY
(Pyrobaculum
calidifontis) 		5 / 10 PHE A 205
ASP A  60
SER A  56
LEU A  67
SER A  83
 None
None
None
FES  A 302 ( 4.1A)
None
 1.28A 3o1xA-4r5qA:
undetectable		 3o1xA-4r5qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY
(Pyrobaculum
calidifontis) 		5 / 10 PHE A 205
ASP A  60
SER A  56
LEU A  67
SER A  83
 None
None
None
FES  A 302 ( 4.1A)
None
 1.26A 3qgzA-4r5qA:
undetectable		 3qgzA-4r5qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY
(Pyrobaculum
calidifontis) 		5 / 12 THR A 148
GLN A 149
VAL A 113
VAL A 119
SER A 155
 None
 1.32A 6bzoC-4r5qA:
undetectable		 6bzoC-4r5qA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY
(Pyrobaculum
calidifontis) 		5 / 12 PRO A  55
ILE A  58
ILE A  57
VAL A 182
ILE A 186
 None
 0.99A 6hlpA-4r5qA:
undetectable		 6hlpA-4r5qA:
17.62