SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  84
LEU A 112
GLN A 116
THR A 214
GLY A 227
 PMP  A 402 (-3.4A)
GOL  A 403 (-4.9A)
GOL  A 403 (-4.0A)
PMP  A 402 (-3.3A)
PMP  A 402 ( 4.6A)
 1.12A 1kvlA-4r5zA:
undetectable		 1kvlA-4r5zA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  70
LEU A 200
GLY A 231
ASP A 240
ALA A 229
 None
 1.15A 2bm9A-4r5zA:
3.5		 2bm9A-4r5zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  70
LEU A 200
GLY A 231
ASP A 240
ALA A 229
 None
 1.12A 2br4C-4r5zA:
3.2		 2br4C-4r5zA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  70
LEU A 200
GLY A 231
ASP A 240
ALA A 229
 None
 1.07A 2br4E-4r5zA:
3.2		 2br4E-4r5zA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  70
VAL A 163
VAL A 188
ILE A 183
 None
 1.13A 2hyyB-4r5zA:
undetectable		 2hyyB-4r5zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A  93
GLY A 227
ARG A 213
LEU A  66
 None
PMP  A 402 ( 4.6A)
None
None
 0.94A 3bjwE-4r5zA:
undetectable		 3bjwE-4r5zA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  70
VAL A 163
VAL A 188
ILE A 183
 None
 1.20A 3k5vA-4r5zA:
undetectable		 3k5vA-4r5zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  70
VAL A 163
VAL A 188
ILE A 183
 None
 1.16A 3k5vB-4r5zA:
undetectable		 3k5vB-4r5zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A  29
ARG A 322
PRO A 323
VAL A 329
 SIN  A 401 (-2.7A)
SIN  A 401 (-3.0A)
None
None
 1.18A 3sufC-4r5zA:
undetectable		 3sufC-4r5zA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 227
GLY A  82
VAL A 248
PHE A 215
ALA A 229
 PMP  A 402 ( 4.6A)
None
None
None
None
 1.15A 4a6dA-4r5zA:
undetectable		 4a6dA-4r5zA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 148
GLY A 100
ILE A 123
GLU A 102
 None
 1.00A 4g0vA-4r5zA:
undetectable		 4g0vA-4r5zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  66
ILE A 226
ALA A 258
SER A 259
LEU A 260
 None
 1.24A 4m11A-4r5zA:
undetectable		 4m11A-4r5zA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 210
LEU A 149
VAL A  95
THR A  96
 None
 0.84A 5e4dA-4r5zA:
undetectable
5e4dB-4r5zA:
undetectable		 5e4dA-4r5zA:
19.28
5e4dB-4r5zA:
19.28