SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4r61 GP41-BASED CONSTRUCT
COVNHR3-ABC
(Human
immunodeficiency
virus
1) 		4 / 5 ALA A  39
GLN A  38
ILE A  41
ARG A 151
 None
 1.41A 2z0aA-4r61A:
4.1		 2z0aA-4r61A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4r61 GP41-BASED CONSTRUCT
COVNHR3-ABC
(Human
immunodeficiency
virus
1) 		4 / 5 ALA A  73
GLN A  74
ILE A  71
ARG A  40
 None
 1.23A 2z0aA-4r61A:
4.1		 2z0aA-4r61A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4r61 GP41-BASED CONSTRUCT
COVNHR3-ABC
(Human
immunodeficiency
virus
1) 		4 / 5 ALA A 150
GLN A 149
ILE A 152
ARG A  72
 None
 1.30A 2z0aA-4r61A:
4.1		 2z0aA-4r61A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 4r61 GP41-BASED CONSTRUCT
COVNHR3-ABC
(Human
immunodeficiency
virus
1) 		3 / 3 GLU A  91
ARG A  94
GLN A  84
 None
 0.70A 4rtbA-4r61A:
undetectable		 4rtbA-4r61A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4r61 GP41-BASED CONSTRUCT
COVNHR3-ABC
(Human
immunodeficiency
virus
1) 		3 / 3 LEU A  85
GLN A  23
LYS A  33
 None
 0.86A 6exiB-4r61A:
undetectable		 6exiB-4r61A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4r61 GP41-BASED CONSTRUCT
COVNHR3-ABC
(Human
immunodeficiency
virus
1) 		3 / 3 LEU A  85
GLN A  23
LYS A  33
 None
 0.88A 6exiA-4r61A:
undetectable		 6exiA-4r61A:
22.01