SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		5 / 12 LEU A 137
LEU A 113
LEU A  89
LEU A 123
LEU A 120
 None
 0.98A 1sqnB-4r6fA:
undetectable		 1sqnB-4r6fA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		5 / 9 LEU A 139
LEU A 123
VAL A 103
LEU A 110
PHE A 128
 None
 1.25A 1tbfA-4r6fA:
undetectable		 1tbfA-4r6fA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		5 / 9 LEU A 243
LEU A 248
VAL A 287
LEU A 297
PHE A 280
 None
 1.26A 1tbfA-4r6fA:
undetectable		 1tbfA-4r6fA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 7 SER A 196
SER A 197
SER A 164
ASN A 194
 None
 1.08A 2cmlA-4r6fA:
undetectable		 2cmlA-4r6fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 7 SER A 276
SER A 277
SER A 244
ASN A 274
 None
 1.11A 2cmlA-4r6fA:
undetectable		 2cmlA-4r6fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 8 SER A 196
SER A 197
SER A 164
ASN A 194
 None
 0.99A 2cmlB-4r6fA:
undetectable		 2cmlB-4r6fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 8 SER A 276
SER A 277
SER A 244
ASN A 274
 None
 1.03A 2cmlB-4r6fA:
undetectable		 2cmlB-4r6fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 8 SER A 196
SER A 197
SER A 164
ASN A 194
 None
 1.06A 2cmlC-4r6fA:
undetectable		 2cmlC-4r6fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 8 SER A 276
SER A 277
SER A 244
ASN A 274
 None
 1.08A 2cmlC-4r6fA:
undetectable		 2cmlC-4r6fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 8 SER A 196
SER A 197
SER A 164
ASN A 194
 None
 1.14A 2cmlD-4r6fA:
undetectable		 2cmlD-4r6fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 6 ASN A  63
ASN A  40
ILE A   2
GLN A  36
 None
 1.20A 2hkkA-4r6fA:
undetectable		 2hkkA-4r6fA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		5 / 12 LEU A  67
LEU A 163
ILE A 147
VAL A 127
VAL A 103
 None
 1.14A 2ygnA-4r6fA:
undetectable		 2ygnA-4r6fA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		5 / 11 ILE A 144
LEU A 113
ASN A  90
LEU A 123
LEU A 161
 None
 1.22A 3a50C-4r6fA:
undetectable		 3a50C-4r6fA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		5 / 12 ILE A 144
LEU A 113
ASN A  90
LEU A 123
LEU A 161
 None
 1.20A 3a50E-4r6fA:
undetectable		 3a50E-4r6fA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		5 / 10 LEU A 163
LEU A 161
ILE A 147
THR A 156
VAL A 127
 None
 1.19A 4mk4A-4r6fA:
undetectable		 4mk4A-4r6fA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 4 ASN A  72
VAL A  55
THR A  20
ILE A  21
 None
 1.40A 4retA-4r6fA:
undetectable		 4retA-4r6fA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 4 ASN A  72
VAL A  55
THR A  20
ILE A  21
 None
 1.40A 4retC-4r6fA:
undetectable		 4retC-4r6fA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 6 VAL A 207
ASN A 176
PRO A 180
ILE A 181
 None
 1.07A 6h7uA-4r6fA:
undetectable		 6h7uA-4r6fA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4r6f LEUCINE RICH REPEAT
DLRR_I
(synthetic
construct) 		4 / 6 VAL A 287
ASN A 256
PRO A 260
ILE A 261
 None
 1.12A 6h7uA-4r6fA:
undetectable		 6h7uA-4r6fA:
25.10