SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 6 LEU A 341
ALA A 329
LEU A 367
SER A 365
 None
 1.04A 1ictB-4r6gA:
undetectable		 1ictB-4r6gA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 LEU A 241
LEU A 217
LEU A 193
LEU A 227
LEU A 224
 None
 0.97A 1sqnB-4r6gA:
undetectable		 1sqnB-4r6gA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 9 LEU A 139
LEU A 123
VAL A 103
LEU A 110
PHE A 128
 None
 1.26A 1tbfA-4r6gA:
undetectable		 1tbfA-4r6gA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 6 ASN A  63
ASN A  40
ILE A   2
GLN A  36
 None
 1.20A 2hkkA-4r6gA:
undetectable		 2hkkA-4r6gA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 ILE A 405
LEU A 429
LEU A 389
ILE A 385
ALA A 381
 None
 0.92A 3a50D-4r6gA:
undetectable		 3a50D-4r6gA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 6 LEU A 341
ALA A 329
LEU A 367
SER A 365
 None
 1.04A 3cfqA-4r6gA:
undetectable		 3cfqA-4r6gA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 LEU A 360
ALA A 353
LEU A 343
LEU A 338
ALA A 359
 None
 1.09A 3dfrA-4r6gA:
undetectable		 3dfrA-4r6gA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		3 / 3 ASP A 371
GLU A 454
SER A 292
 None
 0.82A 3p2kA-4r6gA:
undetectable		 3p2kA-4r6gA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 5 ASN A 290
ASP A 371
GLU A 454
SER A 292
 None
 1.14A 3p2kC-4r6gA:
undetectable		 3p2kC-4r6gA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 6 ALA A 410
ILE A 442
LEU A 434
GLU A 408
 None
 0.87A 3r9sC-4r6gA:
undetectable		 3r9sC-4r6gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 ILE A 348
CYH A 325
ILE A 385
ALA A 381
ALA A 388
 None
 1.09A 4kicB-4r6gA:
undetectable		 4kicB-4r6gA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 4 ASN A  72
VAL A  55
THR A  20
ILE A  21
 None
 1.35A 4retA-4r6gA:
undetectable		 4retA-4r6gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 4 ASN A  72
VAL A  55
THR A  20
ILE A  21
 None
 1.35A 4retC-4r6gA:
undetectable		 4retC-4r6gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 LEU A 203
LEU A 248
ASN A 242
THR A 240
VAL A 255
 None
 1.06A 4x1yD-4r6gA:
undetectable		 4x1yD-4r6gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 7 GLU A 380
ILE A 405
LEU A 424
ILE A 385
 None
 0.84A 4xumA-4r6gA:
undetectable		 4xumA-4r6gA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 7 LEU A 110
GLU A 105
ILE A  58
LYS A  81
 None
 1.08A 5jh7C-4r6gA:
undetectable		 5jh7C-4r6gA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		6 / 10 LEU A 418
GLY A 421
LEU A 446
LEU A 452
THR A 450
ALA A 449
 None
 1.43A 5o96G-4r6gA:
undetectable
5o96H-4r6gA:
undetectable		 5o96G-4r6gA:
19.78
5o96H-4r6gA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 10 ALA A 416
LEU A 417
LEU A 427
GLU A 412
ILE A 442
 None
 1.06A 5v02B-4r6gA:
undetectable
5v02R-4r6gA:
undetectable		 5v02B-4r6gA:
9.80
5v02R-4r6gA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 LEU A  25
LEU A  61
PRO A  62
PHE A  12
THR A   6
 None
 1.20A 6debB-4r6gA:
undetectable		 6debB-4r6gA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 ASN A 118
ASN A 142
LEU A 115
ASN A 114
GLY A  71
 None
 1.13A 6dwnA-4r6gA:
undetectable		 6dwnA-4r6gA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 GLU A 330
LEU A 372
LEU A 377
ALA A 359
LEU A 370
 None
 1.04A 6ew0B-4r6gA:
undetectable		 6ew0B-4r6gA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 GLU A 330
LEU A 372
LEU A 377
ALA A 359
LEU A 370
 None
 1.04A 6ew0D-4r6gA:
undetectable		 6ew0D-4r6gA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 GLU A 330
LEU A 372
LEU A 377
ALA A 359
LEU A 370
 None
 1.03A 6ew0H-4r6gA:
undetectable		 6ew0H-4r6gA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		5 / 12 GLU A 330
LEU A 372
LEU A 377
ALA A 359
LEU A 370
 None
 1.04A 6ew0I-4r6gA:
undetectable		 6ew0I-4r6gA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 6 VAL A 328
LEU A 304
LEU A 310
LEU A 291
 None
 1.06A 6f6sA-4r6gA:
undetectable
6f6sB-4r6gA:
undetectable		 6f6sA-4r6gA:
11.37
6f6sB-4r6gA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4r6g LEUCINE RICH REPEATS
DLRR_K
(synthetic
construct) 		4 / 6 VAL A 207
ASN A 176
PRO A 180
ILE A 181
 None
 1.19A 6h7uA-4r6gA:
undetectable		 6h7uA-4r6gA:
23.65