SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 6 LEU A 235
ILE A 130
ARG A 133
VAL A 266
 None
 0.83A 1db1A-4r6hA:
undetectable		 1db1A-4r6hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 7 GLY A 361
GLN A 397
ARG A 393
VAL A 365
 CL  A 505 (-3.5A)
None
None
None
 0.98A 1rxcD-4r6hA:
undetectable		 1rxcD-4r6hA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 7 ARG A  30
ASP A  27
ASP A  23
PHE A  49
 None
 1.46A 3kivA-4r6hA:
undetectable		 3kivA-4r6hA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 5 ILE A  16
PHE A 305
ASP A 304
GLU A 301
 None
 0.94A 3kp6A-4r6hA:
undetectable
3kp6B-4r6hA:
undetectable		 3kp6A-4r6hA:
16.20
3kp6B-4r6hA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 5 TYR A 209
THR A 208
PHE A 207
LEU A 214
 None
 1.34A 3qelC-4r6hA:
3.1		 3qelC-4r6hA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 6 THR A 368
GLY A 370
ILE A 383
LEU A 366
 None
 1.20A 4ac9C-4r6hA:
2.8		 4ac9C-4r6hA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1480_0
(MJ0495-LIKE PROTEIN)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 4 LYS A 106
GLU A 286
ILE A 104
SER A 103
 None
 1.48A 4ac9C-4r6hA:
2.8		 4ac9C-4r6hA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 6 THR A 368
GLY A 370
ILE A 383
LEU A 366
 None
 1.13A 4acaC-4r6hA:
undetectable		 4acaC-4r6hA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 4 LYS A 106
GLU A 286
ILE A 104
SER A 103
 None
 1.46A 4acaC-4r6hA:
1.0		 4acaC-4r6hA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 4 LYS A 106
GLU A 286
ILE A 104
SER A 103
 None
 1.49A 4acbC-4r6hA:
2.2		 4acbC-4r6hA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 5 ILE A 104
LEU A 101
GLU A 350
VAL A 347
 None
 0.98A 4nkxB-4r6hA:
undetectable		 4nkxB-4r6hA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 6 TYR A  54
GLU A 286
THR A 289
TRP A  76
 None
 1.37A 4qztA-4r6hA:
undetectable		 4qztA-4r6hA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 6 TYR A  54
GLU A 286
THR A 289
TRP A  76
 None
 1.36A 4qzuC-4r6hA:
undetectable		 4qzuC-4r6hA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		5 / 12 ASN A 224
GLY A 250
ASP A 122
GLY A 167
SER A 172
 None
CL  A 503 (-3.9A)
None
None
None
 1.20A 5hikA-4r6hA:
undetectable		 5hikA-4r6hA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 8 GLN A 119
GLY A 327
LEU A 101
ASN A 100
 None
 0.81A 5hwaA-4r6hA:
undetectable		 5hwaA-4r6hA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 6 LEU A 366
ILE A 223
MET A 217
MET A 248
 None
 1.30A 5ljeA-4r6hA:
undetectable		 5ljeA-4r6hA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 7 ASP A  98
GLN A 119
GLN A 345
LYS A 332
 None
 1.34A 6g31A-4r6hA:
undetectable		 6g31A-4r6hA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4r6h SOLUTE BINDING
PROTEIN MSME
(Bacillus
subtilis) 		4 / 7 ASP A  98
GLN A 119
LYS A 121
LYS A 332
 None
 1.08A 6g31A-4r6hA:
undetectable		 6g31A-4r6hA:
11.06