SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		3 / 3 ASN A 327
PHE A 259
VAL A 154
 None
 0.79A 1kijA-4r6iA:
undetectable		 1kijA-4r6iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		5 / 12 LEU A 264
LEU A 262
PHE A 368
LEU A 204
TYR A 283
 None
 1.25A 1kt5A-4r6iA:
undetectable		 1kt5A-4r6iA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		4 / 5 SER A 434
MET A 438
ARG A 405
ILE A 428
 None
 1.37A 1m8dA-4r6iA:
0.0		 1m8dA-4r6iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		4 / 5 SER A 434
MET A 438
ARG A 405
ILE A 428
 None
 1.35A 1m8dB-4r6iA:
0.0		 1m8dB-4r6iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8H_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		4 / 5 SER A 434
MET A 438
ARG A 405
ILE A 428
 None
 1.48A 1m8hB-4r6iA:
0.0		 1m8hB-4r6iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9T_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		4 / 5 SER A 434
MET A 438
ARG A 405
ILE A 428
 None
 1.40A 1m9tA-4r6iA:
0.0		 1m9tA-4r6iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9T_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		4 / 5 SER A 434
MET A 438
ARG A 405
ILE A 428
 None
 1.38A 1m9tB-4r6iA:
0.0		 1m9tB-4r6iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		5 / 12 PHE A 338
SER A 374
ILE A 373
ILE A 319
TYR A 371
 None
 1.32A 1osvB-4r6iA:
undetectable		 1osvB-4r6iA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		5 / 12 PHE A 338
SER A 374
ILE A 373
ILE A 319
TYR A 371
 None
 1.36A 1ot7A-4r6iA:
undetectable		 1ot7A-4r6iA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		5 / 12 VAL A 250
ASN A 177
ILE A 178
LEU A 181
LEU A 252
 None
 1.04A 1r9oA-4r6iA:
undetectable		 1r9oA-4r6iA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6L_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		4 / 5 SER A 434
MET A 438
ARG A 405
ILE A 428
 None
 1.40A 3e6lA-4r6iA:
0.0		 3e6lA-4r6iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		4 / 4 GLU A 293
GLY A 297
THR A 295
GLU A 299
 None
 1.12A 3e9xA-4r6iA:
undetectable		 3e9xA-4r6iA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		5 / 10 ILE A 408
VAL A 396
ILE A 444
ILE A 459
SER A 460
 None
 1.44A 3kpbD-4r6iA:
undetectable		 3kpbD-4r6iA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		3 / 3 SER A 197
MET A 193
ASP A 166
 None
 0.95A 4mm4B-4r6iA:
undetectable		 4mm4B-4r6iA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		5 / 12 ILE A 218
LEU A 260
ALA A 261
PHE A 259
ILE A 207
 None
 0.89A 4pssA-4r6iA:
undetectable		 4pssA-4r6iA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		5 / 12 ILE A 218
LEU A 260
ALA A 261
PHE A 259
ILE A 207
 None
 0.98A 4psyA-4r6iA:
undetectable		 4psyA-4r6iA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		4 / 8 SER A 133
SER A 358
GLU A 372
ASP A 369
 None
 1.39A 4qb9D-4r6iA:
undetectable		 4qb9D-4r6iA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		4 / 6 PHE A 462
PRO A 463
THR A 398
ILE A 408
 None
 1.45A 5ih0A-4r6iA:
undetectable		 5ih0A-4r6iA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		5 / 10 ILE A 471
ILE A 475
LEU A 419
HIS A 404
ILE A 408
 None
 1.42A 5vkqA-4r6iA:
undetectable
5vkqD-4r6iA:
undetectable		 5vkqA-4r6iA:
13.77
5vkqD-4r6iA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		5 / 10 HIS A 404
ILE A 408
ILE A 471
ILE A 475
LEU A 419
 None
 1.41A 5vkqA-4r6iA:
undetectable
5vkqB-4r6iA:
undetectable		 5vkqA-4r6iA:
13.77
5vkqB-4r6iA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		5 / 10 HIS A 404
ILE A 408
ILE A 471
ILE A 475
LEU A 419
 None
 1.42A 5vkqC-4r6iA:
undetectable
5vkqD-4r6iA:
undetectable		 5vkqC-4r6iA:
13.77
5vkqD-4r6iA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		3 / 3 ARG A 384
PHE A 350
LEU A 302
 None
 0.95A 5x1bC-4r6iA:
undetectable		 5x1bC-4r6iA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR
(Bacillus
anthracis) 		4 / 8 ILE A 287
LEU A 266
LEU A 264
ALA A 261
 None
 0.76A 5y7pE-4r6iA:
undetectable		 5y7pE-4r6iA:
22.68