SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4r6j LUCINE RICH REPEATS
DLRR_H
(synthetic
construct) 		5 / 12 LEU A  83
LEU A  74
LEU A  89
LEU A  91
LEU A 107
 None
 1.22A 1mx1C-4r6jA:
undetectable		 1mx1C-4r6jA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r6j LUCINE RICH REPEATS
DLRR_H
(synthetic
construct) 		5 / 9 LEU A 139
LEU A 123
VAL A 103
LEU A 110
PHE A 128
 None
 1.25A 1tbfA-4r6jA:
undetectable		 1tbfA-4r6jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4r6j LUCINE RICH REPEATS
DLRR_H
(synthetic
construct) 		5 / 12 LEU A  96
LEU A 120
LEU A 144
ILE A  77
LEU A 161
 None
 1.13A 2pnjA-4r6jA:
undetectable		 2pnjA-4r6jA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4r6j LUCINE RICH REPEATS
DLRR_H
(synthetic
construct) 		4 / 7 GLN A 229
LEU A 235
VAL A 207
LEU A 219
 None
 0.86A 3g8iA-4r6jA:
undetectable		 3g8iA-4r6jA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4r6j LUCINE RICH REPEATS
DLRR_H
(synthetic
construct) 		3 / 3 LYS A  73
ASN A  90
ASP A  51
 None
 0.84A 4o1eA-4r6jA:
undetectable		 4o1eA-4r6jA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4r6j LUCINE RICH REPEATS
DLRR_H
(synthetic
construct) 		4 / 6 VAL A 103
LEU A  80
LEU A  89
LEU A  74
 None
 0.96A 6f6sA-4r6jA:
undetectable
6f6sB-4r6jA:
undetectable		 6f6sA-4r6jA:
15.61
6f6sB-4r6jA:
14.23