SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		5 / 12 PHE A 212
LEU A 374
LEU A 185
LEU A 207
TYR A 202
 None
 1.08A 1p33B-4r6kA:
undetectable		 1p33B-4r6kA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		5 / 10 TRP A 150
LEU A 162
LEU A 158
TYR A 155
ALA A 133
 None
 1.16A 1pbcA-4r6kA:
undetectable		 1pbcA-4r6kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 8 GLY A 170
PHE A 180
ILE A 248
SER A 246
 None
 1.06A 2a8tB-4r6kA:
undetectable		 2a8tB-4r6kA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		5 / 10 PHE A 308
GLY A 320
GLY A 323
GLU A 342
ILE A 345
 None
 1.49A 3fw1A-4r6kA:
undetectable		 3fw1A-4r6kA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		3 / 3 ASN A 339
GLU A 341
ARG A 261
 None
 0.86A 3wxoA-4r6kA:
undetectable		 3wxoA-4r6kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 8 GLY A 170
LYS A 245
SER A 246
GLU A 229
 None
 0.90A 4hyfB-4r6kA:
undetectable		 4hyfB-4r6kA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 7 ILE A 318
VAL A 326
PHE A 304
ASP A 101
 None
 1.06A 4iarA-4r6kA:
undetectable		 4iarA-4r6kA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 6 LEU A 283
ILE A 105
THR A 123
GLY A 125
 None
 1.02A 4l39A-4r6kA:
undetectable		 4l39A-4r6kA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		3 / 3 ASP A  70
HIS A 297
LYS A 298
 None
 0.88A 4qzuD-4r6kA:
undetectable		 4qzuD-4r6kA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		3 / 3 THR A 249
MET A 174
HIS A 175
 None
 0.99A 5uunA-4r6kA:
undetectable		 5uunA-4r6kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4r6k SOLUTE-BINDING
PROTEIN
(Bacillus
subtilis) 		5 / 12 ALA A 399
GLY A 199
THR A 198
LEU A 374
PHE A 395
 None
 1.19A 5ybbA-4r6kA:
undetectable		 5ybbA-4r6kA:
23.00