SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r6l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 166
VAL A 168
HIS A 286
GLY A 164
 None
 0.85A 1ekjA-4r6lA:
undetectable
1ekjB-4r6lA:
undetectable		 1ekjA-4r6lA:
19.26
1ekjB-4r6lA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 6 PHE A 115
PHE A 245
ASN A 214
ASN A 234
 None
 1.42A 1t9uA-4r6lA:
undetectable		 1t9uA-4r6lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 183
GLN A 157
ASP A 185
LEU A 194
SER A 192
 None
 1.05A 2nv4B-4r6lA:
undetectable		 2nv4B-4r6lA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 7 LEU A 426
ILE A 498
GLN A 330
ALA A 353
 None
 0.84A 2xkwA-4r6lA:
undetectable		 2xkwA-4r6lA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 11 THR A 267
ILE A 222
GLY A 266
HIS A 255
ILE A 262
 BLA  A 900 (-3.3A)
None
None
BLA  A 900 (-3.3A)
None
 1.23A 2y7kA-4r6lA:
undetectable		 2y7kA-4r6lA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 10 THR A 267
ILE A 222
GLY A 266
HIS A 255
ILE A 262
 BLA  A 900 (-3.3A)
None
None
BLA  A 900 (-3.3A)
None
 1.20A 2y7kB-4r6lA:
undetectable		 2y7kB-4r6lA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 10 THR A 267
ILE A 222
GLY A 266
HIS A 255
ILE A 262
 BLA  A 900 (-3.3A)
None
None
BLA  A 900 (-3.3A)
None
 1.25A 2y7pA-4r6lA:
undetectable		 2y7pA-4r6lA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 202
TYR A 171
GLY A 179
PRO A 199
 BLA  A 900 (-3.4A)
BLA  A 900 ( 4.1A)
None
None
 0.96A 2ys6A-4r6lA:
undetectable		 2ys6A-4r6lA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 292
VAL A 104
VAL A 159
ILE A 270
THR A 163
 None
 1.19A 3dl9A-4r6lA:
undetectable		 3dl9A-4r6lA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 GLY A  44
ASN A  47
VAL A  42
ALA A  64
LEU A  31
 None
 1.11A 3p2kB-4r6lA:
undetectable		 3p2kB-4r6lA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 5 ALA A 154
GLU A 158
GLU A 161
ALA A 138
 None
 1.49A 3r9tC-4r6lA:
undetectable		 3r9tC-4r6lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 10 ALA A 328
ARG A 331
LEU A 357
LEU A 333
ASN A 335
 None
 1.05A 3wdmB-4r6lA:
undetectable		 3wdmB-4r6lA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 10 ALA A 328
ARG A 331
LEU A 357
LEU A 333
ASN A 335
 None
 1.10A 3wdmD-4r6lA:
undetectable		 3wdmD-4r6lA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 11 ARG A  75
PHE A  68
ASN A  74
GLY A 105
GLU A 119
 None
 1.42A 4a6nB-4r6lA:
undetectable		 4a6nB-4r6lA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 5 ARG A 260
ILE A 222
HIS A 265
GLY A 263
 None
 1.47A 4e7cC-4r6lA:
undetectable		 4e7cC-4r6lA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 5 THR A  72
THR A  52
LEU A  31
LEU A 118
 None
 1.06A 4lvcB-4r6lA:
undetectable		 4lvcB-4r6lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 359
ALA A 360
ALA A 491
VAL A 492
TRP A 437
 None
 1.33A 4ryaA-4r6lA:
undetectable		 4ryaA-4r6lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 9 LEU A 354
LEU A 340
SER A 332
LEU A 333
ILE A 337
 None
 1.11A 4ubsA-4r6lA:
undetectable		 4ubsA-4r6lA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 ILE A  41
ILE A 247
ILE A 241
LEU A 243
ILE A  26
 None
 1.01A 5mugA-4r6lA:
undetectable		 5mugA-4r6lA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 11 LEU A 142
VAL A 159
ARG A 134
THR A 135
ALA A 138
 None
 1.14A 5o96A-4r6lA:
undetectable
5o96B-4r6lA:
undetectable		 5o96A-4r6lA:
20.35
5o96B-4r6lA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		3 / 3 GLN A 143
TRP A 309
VAL A 313
 None
 1.05A 6auuA-4r6lA:
undetectable		 6auuA-4r6lA:
20.65