SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r6w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 THR A  44
LEU A  41
GLY A  39
TYR A  35
 None
 1.27A 1gtiC-4r6wA:
undetectable		 1gtiC-4r6wA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 GLY A  63
GLY A  65
ILE A  86
ASP A 110
ILE A 111
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-4.1A)
 0.42A 1qaoA-4r6wA:
11.4		 1qaoA-4r6wA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 110
ILE A 111
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
None
SAH  A 302 (-3.6A)
SAH  A 302 (-4.1A)
 0.56A 2b25A-4r6wA:
12.4		 2b25A-4r6wA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 GLY A  63
GLY A  65
GLY A  69
ASP A 110
ILE A 111
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
None
SAH  A 302 (-3.6A)
SAH  A 302 (-4.1A)
 0.89A 2b25A-4r6wA:
12.4		 2b25A-4r6wA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 ILE A  62
GLY A  63
GLY A  65
ALA A 129
HIS A 132
 None
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.3A)
SAH  A 302 (-4.3A)
 0.32A 2fk8A-4r6wA:
27.1		 2fk8A-4r6wA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 TYR A  35
GLY A  65
ASP A  85
ASP A 110
 None
SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
 1.02A 2g72B-4r6wA:
15.7		 2g72B-4r6wA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 ASP A  61
GLY A  63
GLY A  65
ILE A  86
LEU A 133
 SAH  A 302 ( 4.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
None
 0.61A 2nxeB-4r6wA:
13.4		 2nxeB-4r6wA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 ASP A  61
GLY A  63
ASP A  85
ILE A  86
LEU A 133
 SAH  A 302 ( 4.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.7A)
None
 0.63A 3cjtC-4r6wA:
13.3		 3cjtC-4r6wA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 GLY A  63
GLY A  65
GLY A  67
ASP A 110
ILE A 111
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
None
SAH  A 302 (-3.6A)
SAH  A 302 (-4.1A)
 0.84A 3ihtA-4r6wA:
9.1		 3ihtA-4r6wA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 TYR A  19
ASP A  85
ASP A 110
 SAH  A 302 ( 4.1A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
 0.78A 3ou7B-4r6wA:
17.9		 3ou7B-4r6wA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 GLY A  65
ASP A  85
ASP A 110
 SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
 0.33A 3ou7C-4r6wA:
17.8		 3ou7C-4r6wA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 157
TYR A 189
ALA A 263
LEU A 155
LEU A 141
 None
 1.34A 3ozuA-4r6wA:
3.6		 3ozuA-4r6wA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		7 / 12 LEU A  14
TYR A  19
CYH A  87
ILE A  90
ILE A  62
HIS A 132
LEU A 133
 None
SAH  A 302 ( 4.1A)
SAH  A 302 (-3.4A)
None
None
SAH  A 302 (-4.3A)
None
 1.16A 3uj6A-4r6wA:
46.3		 3uj6A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		7 / 12 LEU A  14
TYR A  19
GLY A  63
ILE A  86
CYH A  87
ILE A  84
ARG A 127
 None
SAH  A 302 ( 4.1A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
None
 1.31A 3uj6A-4r6wA:
46.3		 3uj6A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		11 / 12 LEU A  14
TYR A  19
ILE A  36
GLY A  63
ILE A  86
CYH A  87
ILE A  90
ILE A 111
ARG A 127
HIS A 132
LEU A 133
 None
SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
SAH  A 302 (-4.1A)
None
SAH  A 302 (-4.3A)
None
 0.47A 3uj6A-4r6wA:
46.3		 3uj6A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 4 SER A  37
ASP A  85
ASP A 110
ALA A 129
 SAH  A 302 (-2.5A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.3A)
 0.21A 3uj6A-4r6wA:
46.3		 3uj6A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		7 / 12 LEU A  14
TYR A  19
GLY A  63
ILE A  86
CYH A  87
ILE A  84
ARG A 127
 None
SAH  A 302 ( 4.1A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
None
 1.34A 3uj7A-4r6wA:
46.3		 3uj7A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		10 / 12 LEU A  14
TYR A  19
ILE A  36
GLY A  63
ILE A  86
CYH A  87
ILE A 111
ARG A 127
ALA A 129
HIS A 132
 None
SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-3.3A)
SAH  A 302 (-4.3A)
 0.27A 3uj7A-4r6wA:
46.3		 3uj7A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		9 / 12 LEU A  14
TYR A  19
ILE A  36
ILE A  86
CYH A  87
ILE A  90
ILE A 111
ARG A 127
HIS A 132
 None
SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
SAH  A 302 (-4.1A)
None
SAH  A 302 (-4.3A)
 0.47A 3uj7A-4r6wA:
46.3		 3uj7A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		10 / 12 LEU A  14
ILE A  36
GLY A  63
GLY A  65
ILE A  86
CYH A  87
ARG A 127
ALA A 129
HIS A 132
LEU A 133
 None
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
SAH  A 302 (-3.3A)
SAH  A 302 (-4.3A)
None
 0.28A 3uj7B-4r6wA:
46.2		 3uj7B-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		8 / 12 LEU A  14
ILE A  36
GLY A  65
ILE A  86
CYH A  87
ILE A  90
ARG A 127
HIS A 132
 None
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
None
SAH  A 302 (-4.3A)
 0.49A 3uj7B-4r6wA:
46.2		 3uj7B-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 5 TYR A  19
SER A  37
ASP A  85
ASP A 110
ILE A 111
 SAH  A 302 ( 4.1A)
SAH  A 302 (-2.5A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
SAH  A 302 (-4.1A)
 0.16A 3uj7B-4r6wA:
46.2		 3uj7B-4r6wA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 11 GLY A  65
ASP A  85
ASP A 110
TYR A 160
LEU A 133
 SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
PC  A 301 (-4.4A)
None
 0.82A 3v8vB-4r6wA:
12.0		 3v8vB-4r6wA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 TYR A  77
TYR A  72
LEU A  41
GLY A  40
LEU A 156
 None
 0.97A 3vywC-4r6wA:
10.2		 3vywC-4r6wA:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 7 GLU A 174
TYR A 175
ARG A 179
GLY A 243
LYS A 247
 None
PC  A 301 (-4.5A)
PC  A 301 (-3.9A)
None
PC  A 301 (-2.7A)
 0.38A 4fgzA-4r6wA:
44.8		 4fgzA-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		7 / 8 GLY A  32
GLY A  39
TYR A 209
LEU A 213
VAL A 216
GLU A 217
TYR A 220
 None
 0.44A 4fgzB-4r6wA:
44.8		 4fgzB-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 8 GLU A 174
TYR A 175
ARG A 179
GLY A 243
LYS A 247
 None
PC  A 301 (-4.5A)
PC  A 301 (-3.9A)
None
PC  A 301 (-2.7A)
 0.51A 4fgzA-4r6wA:
44.8
4fgzB-4r6wA:
44.8		 4fgzA-4r6wA:
99.61
4fgzB-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		8 / 12 TYR A  19
ILE A  36
GLY A  63
GLY A  65
ILE A  86
CYH A  87
ILE A 111
ARG A 127
 SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
SAH  A 302 (-4.1A)
None
 0.70A 4iv0A-4r6wA:
41.6		 4iv0A-4r6wA:
60.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		9 / 12 TYR A  19
ILE A  36
GLY A  63
GLY A  65
ILE A  86
ILE A 111
ARG A 127
HIS A 132
LEU A 133
 SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-4.3A)
None
 0.32A 4iv0A-4r6wA:
41.6		 4iv0A-4r6wA:
60.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		8 / 12 TYR A  19
ILE A  36
GLY A  63
GLY A  65
CYH A  87
ASP A 110
ILE A 111
ARG A 127
 SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.4A)
SAH  A 302 (-3.6A)
SAH  A 302 (-4.1A)
None
 0.71A 4iv0B-4r6wA:
40.2		 4iv0B-4r6wA:
60.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		9 / 12 TYR A  19
ILE A  36
GLY A  63
GLY A  65
ILE A  86
ASP A 110
ILE A 111
ARG A 127
HIS A 132
 SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-4.3A)
 0.33A 4iv0B-4r6wA:
40.2		 4iv0B-4r6wA:
60.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		6 / 12 GLY A  63
GLY A  65
ASP A  85
CYH A  87
ARG A 127
LEU A 141
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.4A)
None
None
 0.93A 4iv8A-4r6wA:
35.1		 4iv8A-4r6wA:
60.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		7 / 12 GLY A  63
GLY A  65
ASP A  85
CYH A  87
ILE A 111
ARG A 127
ALA A 129
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.4A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-3.3A)
 0.80A 4iv8A-4r6wA:
35.1		 4iv8A-4r6wA:
60.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		10 / 12 GLY A  63
GLY A  65
ASP A  85
ILE A  86
ASP A 110
ILE A 111
ARG A 127
ALA A 129
HIS A 132
LEU A 133
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-3.3A)
SAH  A 302 (-4.3A)
None
 0.39A 4iv8A-4r6wA:
35.1		 4iv8A-4r6wA:
60.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		6 / 12 GLY A  63
GLY A  65
ASP A  85
CYH A  87
ARG A 127
LEU A 141
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.4A)
None
None
 0.93A 4iv8B-4r6wA:
35.0		 4iv8B-4r6wA:
60.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		7 / 12 GLY A  63
GLY A  65
ASP A  85
CYH A  87
ILE A 111
ARG A 127
ALA A 129
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.4A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-3.3A)
 0.82A 4iv8B-4r6wA:
35.0		 4iv8B-4r6wA:
60.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		10 / 12 GLY A  63
GLY A  65
ASP A  85
ILE A  86
ASP A 110
ILE A 111
ARG A 127
ALA A 129
HIS A 132
LEU A 133
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-3.3A)
SAH  A 302 (-4.3A)
None
 0.42A 4iv8B-4r6wA:
35.0		 4iv8B-4r6wA:
60.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		6 / 12 TYR A  19
GLY A  63
GLY A  65
ASP A 110
ARG A 127
HIS A 132
 SAH  A 302 ( 4.1A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.6A)
None
SAH  A 302 (-4.3A)
 0.49A 4krhA-4r6wA:
37.7		 4krhA-4r6wA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 TYR A  19
GLY A  63
GLY A  65
ARG A 127
HIS A 132
 SAH  A 302 ( 4.1A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
None
SAH  A 302 (-4.3A)
 0.49A 4krhB-4r6wA:
37.9		 4krhB-4r6wA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 4 ILE A  36
SER A  37
ASP A  85
ASP A 110
 SAH  A 302 ( 3.9A)
SAH  A 302 (-2.5A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
 0.62A 4krhB-4r6wA:
37.9		 4krhB-4r6wA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		7 / 12 TYR A  19
ILE A  36
GLY A  63
GLY A  65
CYH A  87
ILE A 111
ARG A 127
 SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.4A)
SAH  A 302 (-4.1A)
None
 0.75A 4mwzA-4r6wA:
41.1		 4mwzA-4r6wA:
63.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		9 / 12 TYR A  19
ILE A  36
GLY A  63
GLY A  65
ILE A  86
ILE A 111
ARG A 127
HIS A 132
LEU A 133
 SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-4.3A)
None
 0.33A 4mwzA-4r6wA:
41.1		 4mwzA-4r6wA:
63.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 SER A  37
ASP A  85
ASP A 110
 SAH  A 302 (-2.5A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
 0.32A 4mwzA-4r6wA:
41.1		 4mwzA-4r6wA:
63.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 8 GLY A  32
GLY A  39
LEU A 213
GLU A 217
 None
 0.48A 4mwzB-4r6wA:
undetectable		 4mwzB-4r6wA:
63.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 8 GLY A  39
LEU A 213
GLU A 217
LYS A 219
 None
 0.78A 4mwzB-4r6wA:
undetectable		 4mwzB-4r6wA:
63.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		8 / 12 TYR A  19
ILE A  36
GLY A  63
GLY A  65
CYH A  87
ILE A 111
ARG A 127
HIS A 132
 SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.4A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-4.3A)
 0.66A 4mwzB-4r6wA:
41.6		 4mwzB-4r6wA:
63.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		9 / 12 TYR A  19
ILE A  36
GLY A  63
GLY A  65
ILE A  86
ILE A 111
ARG A 127
HIS A 132
LEU A 133
 SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-4.3A)
None
 0.33A 4mwzB-4r6wA:
41.6		 4mwzB-4r6wA:
63.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 ILE A  47
THR A  44
THR A 158
LEU A  48
ASP A  61
 None
None
None
None
SAH  A 302 ( 4.6A)
 1.25A 4pbhA-4r6wA:
undetectable		 4pbhA-4r6wA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 TYR A  19
GLY A  63
GLY A  65
ILE A  86
ALA A 129
 SAH  A 302 ( 4.1A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.3A)
 0.73A 4qtuB-4r6wA:
18.9		 4qtuB-4r6wA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 4 ASP A  61
GLY A  65
ASP A  85
ASP A 110
 SAH  A 302 ( 4.6A)
SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
 0.57A 5e72A-4r6wA:
14.0		 5e72A-4r6wA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 TYR A 181
TYR A  27
GLN A  18
 PC  A 301 (-4.7A)
PC  A 301 (-4.0A)
PC  A 301 (-4.2A)
 0.93A 5jsdA-4r6wA:
undetectable
5jsdB-4r6wA:
undetectable		 5jsdA-4r6wA:
15.28
5jsdB-4r6wA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 TYR A 181
TYR A  27
GLN A  18
 PC  A 301 (-4.7A)
PC  A 301 (-4.0A)
PC  A 301 (-4.2A)
 0.93A 5jsdB-4r6wA:
undetectable
5jsdC-4r6wA:
undetectable		 5jsdB-4r6wA:
15.28
5jsdC-4r6wA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 SER A  37
GLY A  63
GLY A  65
ASP A 110
ALA A 128
 SAH  A 302 (-2.5A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.6A)
PC  A 301 ( 3.8A)
 0.51A 5kpcB-4r6wA:
22.9		 5kpcB-4r6wA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 GLY A  63
GLY A  65
ASP A  85
HIS A 132
LEU A 133
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-4.3A)
None
 0.65A 5wy0A-4r6wA:
13.1		 5wy0A-4r6wA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 GLY A  63
GLY A  65
ASP A  85
ILE A  86
LEU A 133
 SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.7A)
None
 0.50A 5wy0A-4r6wA:
13.1		 5wy0A-4r6wA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 ARG A 127
ALA A 128
THR A 158
ALA A  43
 None
PC  A 301 ( 3.8A)
None
None
 1.06A 6ma6A-4r6wA:
undetectable		 6ma6A-4r6wA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 GLY A  65
LEU A  66
GLY A  68
ASP A 110
ILE A 111
 SAH  A 302 (-3.6A)
None
None
SAH  A 302 (-3.6A)
SAH  A 302 (-4.1A)
 0.42A 6mhtA-4r6wA:
7.6		 6mhtA-4r6wA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 8 LEU A  66
ASP A  21
THR A  20
TYR A  19
 None
None
None
SAH  A 302 ( 4.1A)
 1.09A 6nknC-4r6wA:
undetectable
6nknN-4r6wA:
undetectable
6nknP-4r6wA:
undetectable		 6nknC-4r6wA:
21.48
6nknN-4r6wA:
18.31
6nknP-4r6wA:
21.48