SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 6 LEU A 245
ILE A 327
TYR A 154
VAL A 319
 None
 1.06A 1db1A-4r6yA:
undetectable		 1db1A-4r6yA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 6 PHE A  45
LEU A 119
VAL A  83
VAL A  25
 None
 1.18A 1dz4B-4r6yA:
undetectable		 1dz4B-4r6yA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 6 ALA A 320
SER A 117
TRP A 312
LEU A 323
 None
 1.23A 1gahA-4r6yA:
undetectable		 1gahA-4r6yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		5 / 12 ASP A  35
GLY A  32
ASP A  31
GLY A 199
ASP A 162
 None
GOL  A 401 ( 4.5A)
GOL  A 401 (-4.0A)
None
ACT  A 402 (-3.4A)
 1.40A 2fqyA-4r6yA:
2.6		 2fqyA-4r6yA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		5 / 11 ALA A 161
PHE A  88
ILE A 327
PRO A 157
GLY A 158
 ACT  A 402 (-4.1A)
None
None
None
None
 1.27A 3bpxA-4r6yA:
undetectable
3bpxB-4r6yA:
undetectable		 3bpxA-4r6yA:
18.36
3bpxB-4r6yA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 8 GLY A 215
ASN A 220
TRP A 234
PHE A 233
 None
 1.20A 3ccfA-4r6yA:
undetectable		 3ccfA-4r6yA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		3 / 3 ASN A 122
ASP A 162
ARG A 226
 GOL  A 401 (-4.1A)
ACT  A 402 (-3.4A)
None
 0.93A 3k13C-4r6yA:
undetectable		 3k13C-4r6yA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 8 TYR A  41
THR A  84
TYR A  58
LEU A  70
 None
 1.30A 3wipG-4r6yA:
undetectable
3wipH-4r6yA:
undetectable		 3wipG-4r6yA:
22.26
3wipH-4r6yA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 8 GLN A 153
ILE A 210
GLY A 199
ASN A 220
 None
 0.99A 4fgjA-4r6yA:
undetectable
4fgjB-4r6yA:
undetectable		 4fgjA-4r6yA:
22.22
4fgjB-4r6yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		5 / 10 PRO A 157
MET A 167
ALA A 170
PHE A 171
LEU A 323
 None
 1.33A 4la0A-4r6yA:
undetectable		 4la0A-4r6yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 7 VAL A 166
MET A 167
ALA A 170
PHE A 171
 None
 1.16A 4lb2A-4r6yA:
undetectable		 4lb2A-4r6yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B602_1
(SERUM ALBUMIN)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		5 / 9 PRO A 157
VAL A 166
MET A 167
PHE A 181
PHE A 171
 None
 1.41A 4lb2B-4r6yA:
undetectable		 4lb2B-4r6yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		5 / 12 LEU A  98
ALA A  92
LEU A  70
THR A  26
ALA A  99
 None
 1.26A 4x1iB-4r6yA:
undetectable		 4x1iB-4r6yA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 7 LYS A 149
LYS A 151
TYR A 154
LEU A 201
 None
 1.13A 4yv5A-4r6yA:
undetectable		 4yv5A-4r6yA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 7 LYS A 149
LYS A 151
TYR A 154
LEU A 201
 None
 1.15A 4yv5B-4r6yA:
undetectable		 4yv5B-4r6yA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		3 / 3 ALA A  51
PHE A 269
GLN A  44
 None
 0.79A 6eceA-4r6yA:
undetectable		 6eceA-4r6yA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_1
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 4 ASP A 216
SER A 197
SER A 155
ASN A 220
 GOL  A 401 ( 4.0A)
ACT  A 402 (-4.9A)
ACT  A 402 ( 4.4A)
None
 1.28A 6iblA-4r6yA:
0.0		 6iblA-4r6yA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_1
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN
(Salmonella
enterica) 		4 / 4 ASP A 216
SER A 197
SER A 155
ASN A 220
 GOL  A 401 ( 4.0A)
ACT  A 402 (-4.9A)
ACT  A 402 ( 4.4A)
None
 1.29A 6iblB-4r6yA:
0.5		 6iblB-4r6yA:
20.87