SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		3 / 3 SER A 365
GLU A 367
GLU A 366
 None
 0.69A 1eqbD-4r70A:
undetectable		 1eqbD-4r70A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		3 / 3 SER A 365
GLU A 367
GLU A 366
 None
 0.70A 1eqbB-4r70A:
undetectable		 1eqbB-4r70A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		4 / 6 TYR A 308
PRO A 229
GLU A 315
ARG A 311
 None
 1.26A 1oniA-4r70A:
undetectable
1oniC-4r70A:
undetectable		 1oniA-4r70A:
13.26
1oniC-4r70A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		5 / 12 ILE A 317
ILE A 182
VAL A 184
ALA A 197
LEU A 162
 None
 1.03A 1uduB-4r70A:
undetectable		 1uduB-4r70A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 462
GLY A 463
ASP A 209
PHE A 210
SER A 483
 None
 1.20A 1xdsA-4r70A:
undetectable		 1xdsA-4r70A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 462
GLY A 463
ASP A 209
PHE A 210
SER A 483
 None
 1.16A 1xdsB-4r70A:
undetectable		 1xdsB-4r70A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		5 / 11 LEU A 379
LEU A 361
VAL A 514
GLY A 519
ARG A 520
 None
 1.50A 1y4lB-4r70A:
undetectable		 1y4lB-4r70A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 360
SER A 362
PHE A 388
ALA A 386
VAL A 385
 None
 0.66A 2oc8A-4r70A:
undetectable		 2oc8A-4r70A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		4 / 5 ILE A  39
LEU A  45
ASP A 246
ALA A  38
 None
 1.05A 2opxA-4r70A:
undetectable		 2opxA-4r70A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 216
TYR A 185
GLY A 193
PRO A 213
 BLA  A 900 (-3.6A)
BLA  A 900 ( 4.7A)
None
None
 1.04A 2ys6A-4r70A:
undetectable		 2ys6A-4r70A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		4 / 6 ILE A 128
VAL A  47
LEU A  45
LEU A 257
 None
 0.79A 3kp6A-4r70A:
undetectable
3kp6B-4r70A:
undetectable		 3kp6A-4r70A:
14.63
3kp6B-4r70A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		4 / 6 HIS A 269
HIS A 299
SER A 297
ASP A 190
 BLA  A 900 (-3.3A)
BLA  A 900 (-4.0A)
BLA  A 900 (-3.2A)
None
 1.25A 4blvA-4r70A:
undetectable		 4blvA-4r70A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		3 / 3 ARG A 481
THR A 460
TRP A 461
 None
 1.19A 4d7hA-4r70A:
undetectable		 4d7hA-4r70A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		3 / 3 ARG A 481
THR A 460
TRP A 461
 None
 1.16A 4ug5A-4r70A:
undetectable		 4ug5A-4r70A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		3 / 3 ARG A 481
THR A 460
TRP A 461
 None
 1.16A 4uglA-4r70A:
undetectable		 4uglA-4r70A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		5 / 8 GLU A 366
SER A 365
PHE A 388
GLY A 376
THR A 358
 None
 1.08A 5flcB-4r70A:
undetectable		 5flcB-4r70A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		5 / 8 GLU A 366
SER A 365
PHE A 388
GLY A 376
THR A 358
 None
 1.07A 5flcF-4r70A:
2.1		 5flcF-4r70A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		3 / 3 ARG A 481
THR A 460
TRP A 461
 None
 1.18A 5g6cA-4r70A:
undetectable		 5g6cA-4r70A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 165
LEU A 321
ILE A 317
SER A 171
VAL A 327
 None
 1.44A 5uanB-4r70A:
undetectable		 5uanB-4r70A:
19.75