SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		4 / 6 SER B  62
THR B  54
LEU B  50
ASP B  52
 None
 1.36A 1mxdA-4r7aB:
undetectable		 1mxdA-4r7aB:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		4 / 4 ILE B 390
GLN B  48
ILE B 377
LEU B  50
 None
 1.29A 3dzyD-4r7aB:
undetectable		 3dzyD-4r7aB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		5 / 10 SER B 280
LEU B 306
ILE B 254
SER B 234
GLY B 244
 None
 1.22A 3ijxB-4r7aB:
undetectable
3ijxD-4r7aB:
undetectable		 3ijxB-4r7aB:
19.67
3ijxD-4r7aB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		5 / 10 SER B 280
LEU B 306
ILE B 254
SER B 234
GLY B 244
 None
 1.34A 3iluB-4r7aB:
undetectable
3iluE-4r7aB:
undetectable		 3iluB-4r7aB:
19.67
3iluE-4r7aB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		5 / 11 ILE B 254
SER B 234
GLY B 244
SER B 280
LEU B 306
 None
 1.27A 3iluB-4r7aB:
undetectable
3iluE-4r7aB:
undetectable		 3iluB-4r7aB:
19.67
3iluE-4r7aB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		4 / 7 ASP B 199
GLY B 180
THR B 201
LYS B 143
 None
 1.16A 3vnsA-4r7aB:
undetectable		 3vnsA-4r7aB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		4 / 4 PRO B 363
LEU B 366
ILE B 369
ARG B 341
 None
 1.42A 3w1wA-4r7aB:
undetectable		 3w1wA-4r7aB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		5 / 11 HIS B 226
SER B 245
ILE B 202
TRP B 205
GLY B 180
 None
 1.22A 4fogA-4r7aB:
undetectable		 4fogA-4r7aB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		3 / 3 GLN B 322
SER B 234
ASP B 232
 None
 0.94A 4qwpA-4r7aB:
undetectable
4qwpB-4r7aB:
undetectable		 4qwpA-4r7aB:
18.94
4qwpB-4r7aB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		4 / 7 ASP B 199
GLY B 180
THR B 201
LYS B 143
 None
 1.12A 4zxiA-4r7aB:
undetectable		 4zxiA-4r7aB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		4 / 5 THR B 297
GLY B 292
GLU B 275
ASP B 295
 None
 1.18A 5c0oH-4r7aB:
undetectable		 5c0oH-4r7aB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		4 / 6 LEU B  86
CYH B 391
HIS B  64
LEU B  66
 None
 1.41A 5hrqD-4r7aB:
undetectable
5hrqG-4r7aB:
undetectable
5hrqH-4r7aB:
undetectable		 5hrqD-4r7aB:
10.28
5hrqG-4r7aB:
3.97
5hrqH-4r7aB:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens) 		3 / 3 LYS B 376
ASP B 339
ILE B 398
 None
 0.79A 5kc4E-4r7aB:
undetectable		 5kc4E-4r7aB:
17.97