SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 8 PHE A 182
PHE A 224
PHE A 216
LEU A 177
 None
 0.86A 1fslB-4r7bA:
undetectable		 1fslB-4r7bA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		5 / 9 LEU A 192
PHE A 182
ALA A 110
LEU A 207
LEU A 210
 None
 1.08A 1nr6A-4r7bA:
undetectable		 1nr6A-4r7bA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A  98
GLU A 220
ARG A 275
 None
 0.78A 1wopA-4r7bA:
undetectable		 1wopA-4r7bA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 5 PRO A 129
LEU A 163
GLY A 167
LYS A 239
 None
 1.13A 1ya4C-4r7bA:
undetectable		 1ya4C-4r7bA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 7 VAL A 156
THR A 249
LEU A 253
TRP A 205
 None
 1.05A 3arrA-4r7bA:
undetectable		 3arrA-4r7bA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		5 / 12 HIS A 117
ILE A 112
LEU A 210
ALA A 209
PHE A 182
 None
 0.97A 3b2rA-4r7bA:
undetectable		 3b2rA-4r7bA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		5 / 11 HIS A 117
ILE A 112
LEU A 210
ALA A 209
PHE A 182
 None
 0.98A 3b2rB-4r7bA:
undetectable		 3b2rB-4r7bA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		5 / 9 GLN A 274
ASP A 248
ILE A 245
VAL A 156
VAL A 152
 None
 1.46A 3fi0C-4r7bA:
undetectable		 3fi0C-4r7bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		5 / 9 GLN A 274
ASP A 248
ILE A 245
VAL A 156
VAL A 152
 None
 1.44A 3fi0H-4r7bA:
undetectable		 3fi0H-4r7bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		5 / 9 GLN A 274
ASP A 248
ILE A 245
VAL A 156
VAL A 152
 None
 1.40A 3fi0L-4r7bA:
undetectable		 3fi0L-4r7bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		5 / 9 GLN A 274
ASP A 248
ILE A 245
VAL A 156
VAL A 152
 None
 1.44A 3fi0N-4r7bA:
undetectable		 3fi0N-4r7bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MES_A_DMEA427_1
(CHOLINE KINASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		5 / 10 ASP A 176
GLU A 213
TRP A 251
TRP A 254
TYR A 268
 CHT  A 301 (-2.8A)
CHT  A 301 (-4.2A)
CHT  A 301 ( 3.6A)
CHT  A 301 (-3.9A)
None
 0.79A 3mesA-4r7bA:
23.2		 3mesA-4r7bA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MES_B_DMEB427_1
(CHOLINE KINASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		5 / 10 ASP A 176
GLU A 213
TRP A 251
TRP A 254
TYR A 268
 CHT  A 301 (-2.8A)
CHT  A 301 (-4.2A)
CHT  A 301 ( 3.6A)
CHT  A 301 (-3.9A)
None
 0.82A 3mesB-4r7bA:
23.1		 3mesB-4r7bA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 198
SER A 199
HIS A 117
 None
 0.79A 3mzeA-4r7bA:
undetectable		 3mzeA-4r7bA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 8 TRP A 251
ILE A 144
TYR A 146
GLY A 269
 CHT  A 301 ( 3.6A)
None
None
None
 0.93A 3n9jA-4r7bA:
undetectable		 3n9jA-4r7bA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 4 LEU A 280
ILE A 250
TYR A 243
TYR A 273
 None
 1.36A 3vt7A-4r7bA:
undetectable		 3vt7A-4r7bA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 5 GLU A  65
ASP A  80
ASP A  59
GLU A  82
 None
 1.27A 3vywD-4r7bA:
undetectable		 3vywD-4r7bA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		5 / 12 CYH A 173
ALA A 209
ASP A 202
ALA A 208
TYR A 228
 None
 1.13A 4lg1C-4r7bA:
undetectable		 4lg1C-4r7bA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 6 PHE A  47
ARG A  57
THR A  29
ILE A  55
 None
 1.36A 5ih0A-4r7bA:
17.3		 5ih0A-4r7bA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A  32
ASN A  88
ASP A  73
ASN A 181
 None
 1.46A 5vooA-4r7bA:
undetectable		 5vooA-4r7bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A  32
ASN A  88
ASP A  73
ASN A 181
 None
 1.46A 5vooC-4r7bA:
undetectable		 5vooC-4r7bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A  32
ASN A  88
ASP A  73
ASN A 181
 None
 1.46A 5vooE-4r7bA:
undetectable		 5vooE-4r7bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		3 / 3 LYS A  40
ASN A  39
SER A  14
 None
 1.06A 5yw0A-4r7bA:
undetectable		 5yw0A-4r7bA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 4r7b CHOLINE KINASE
(Streptococcus
pneumoniae) 		4 / 5 GLU A 229
PRO A 234
THR A 233
MET A 204
 None
 1.43A 6fgdA-4r7bA:
undetectable		 6fgdA-4r7bA:
18.50