SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_2
(GLUCOAMYLASE-471)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		4 / 4 TRP A  99
GLU A 133
LEU A 159
TRP A 158
 None
 1.44A 1agmA-4r7kA:
undetectable		 1agmA-4r7kA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_2
(GLUCOAMYLASE-471)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		4 / 5 TRP A  99
GLU A 133
LEU A 159
TRP A 158
 None
 1.44A 1agmA-4r7kA:
undetectable		 1agmA-4r7kA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		5 / 12 ILE A  27
LEU A  31
GLY A  30
VAL A 163
ALA A 164
 None
 1.08A 1axwA-4r7kA:
undetectable		 1axwA-4r7kA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		4 / 5 HIS A 155
TRP A  46
ALA A  83
TRP A  99
 None
 0.94A 1dy4A-4r7kA:
undetectable		 1dy4A-4r7kA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		3 / 4 VAL A  85
TRP A  13
TRP A  99
 None
 1.15A 1gmkA-4r7kA:
undetectable
1gmkB-4r7kA:
undetectable		 1gmkA-4r7kA:
12.35
1gmkB-4r7kA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		5 / 12 ILE A  27
LEU A  31
GLY A  30
VAL A 163
ALA A 164
 None
 1.06A 1tlsA-4r7kA:
undetectable		 1tlsA-4r7kA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		5 / 12 ILE A  27
LEU A  31
GLY A  30
VAL A 163
ALA A 164
 None
 1.04A 1tlsB-4r7kA:
undetectable		 1tlsB-4r7kA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		5 / 9 GLY A 101
ALA A  83
TRP A  46
PHE A  74
LEU A  66
 None
 1.22A 1y7iA-4r7kA:
undetectable		 1y7iA-4r7kA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_2
(GLUCOAMYLASE GLU1)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		4 / 4 TRP A  99
GLU A 133
LEU A 159
TRP A 158
 None
 1.40A 2f6dA-4r7kA:
0.0		 2f6dA-4r7kA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		4 / 7 LEU A 111
ASN A 103
GLU A  82
MET A 151
 None
None
CME  A  73 ( 3.5A)
None
 1.15A 2w8yA-4r7kA:
undetectable		 2w8yA-4r7kA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		4 / 7 GLU A 104
TYR A  59
ARG A  71
GLU A  82
 None
None
None
CME  A  73 ( 3.5A)
 1.26A 2zt7A-4r7kA:
undetectable		 2zt7A-4r7kA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		4 / 8 PHE A  79
GLY A  78
GLY A 101
MET A 151
 None
 0.95A 3v3nB-4r7kA:
2.3		 3v3nB-4r7kA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		4 / 8 PHE A  79
GLY A  78
GLY A 101
MET A 151
 None
 0.94A 3v3nC-4r7kA:
2.3		 3v3nC-4r7kA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		3 / 3 TRP A  46
VAL A  36
TRP A 158
 None
 1.39A 3zq8A-4r7kA:
undetectable
3zq8B-4r7kA:
undetectable		 3zq8A-4r7kA:
12.35
3zq8B-4r7kA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4r7k HYPOTHETICAL PROTEIN
JHP0584
(Helicobacter
pylori) 		5 / 12 ILE A  27
LEU A  31
GLY A  30
VAL A 163
ALA A 164
 None
 1.09A 4foxD-4r7kA:
undetectable		 4foxD-4r7kA:
20.45