SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		5 / 11 GLU A  70
GLY A  45
LEU A  69
VAL A 133
PRO A 134
 MG  A 401 ( 3.2A)
None
None
None
None
 1.26A 1i9jH-4r7oA:
undetectable
1i9jL-4r7oA:
undetectable		 1i9jH-4r7oA:
19.45
1i9jL-4r7oA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		3 / 3 ASP A  86
ARG A  91
ASP A  72
 None
None
MG  A 401 (-3.0A)
 0.82A 1vptA-4r7oA:
undetectable		 1vptA-4r7oA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		3 / 3 GLU A 152
HIS A  43
GLU A  70
 MG  A 401 ( 3.1A)
GOL  A 405 (-3.8A)
MG  A 401 ( 3.2A)
 0.58A 2x45B-4r7oA:
undetectable		 2x45B-4r7oA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		3 / 3 GLU A 152
HIS A  43
GLU A  70
 MG  A 401 ( 3.1A)
GOL  A 405 (-3.8A)
MG  A 401 ( 3.2A)
 0.61A 2x45C-4r7oA:
undetectable		 2x45C-4r7oA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		5 / 12 ILE A 262
GLY A 250
LEU A 211
PRO A 231
ILE A 249
 None
 1.18A 2y7kD-4r7oA:
undetectable		 2y7kD-4r7oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		5 / 11 ILE A 139
LEU A 166
LEU A  71
ILE A 151
LEU A 175
 None
 1.25A 3a50C-4r7oA:
undetectable		 3a50C-4r7oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		5 / 12 ILE A 139
LEU A 166
LEU A  71
ILE A 151
LEU A 175
 None
 1.23A 3a50E-4r7oA:
undetectable		 3a50E-4r7oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		5 / 9 LEU A 166
LEU A 169
ALA A  83
GLN A 188
TYR A 150
 None
None
None
GOL  A 405 (-2.9A)
None
 1.46A 3cldA-4r7oA:
undetectable		 3cldA-4r7oA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		5 / 12 LEU A 195
ILE A 249
GLY A 248
TYR A 150
HIS A 278
 None
 1.40A 3hgiA-4r7oA:
undetectable		 3hgiA-4r7oA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		4 / 5 TYR A  68
SER A 183
ASP A  72
ILE A  73
 None
None
MG  A 401 (-3.0A)
None
 1.34A 3uj7B-4r7oA:
undetectable		 3uj7B-4r7oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		4 / 6 PRO A 251
ILE A 227
TYR A 266
TYR A 213
 None
 1.14A 4g10A-4r7oA:
undetectable		 4g10A-4r7oA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		3 / 3 ARG A  44
HIS A  53
SER A  47
 None
 0.76A 4mjwA-4r7oA:
undetectable
4mjwB-4r7oA:
undetectable		 4mjwA-4r7oA:
19.69
4mjwB-4r7oA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		3 / 3 SER A  47
ARG A  44
HIS A  53
 None
 0.73A 4mjwA-4r7oA:
undetectable
4mjwB-4r7oA:
undetectable		 4mjwA-4r7oA:
19.69
4mjwB-4r7oA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		5 / 12 TYR A 150
GLY A 250
ILE A 282
ARG A 271
LEU A 307
 None
 1.10A 4mwzA-4r7oA:
undetectable		 4mwzA-4r7oA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		4 / 5 TYR A 150
LEU A 166
GLU A 152
VAL A 158
 None
None
MG  A 401 ( 3.1A)
None
 1.18A 4nkvA-4r7oA:
undetectable		 4nkvA-4r7oA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		4 / 6 TYR A 150
LEU A 166
GLU A 152
VAL A 158
 None
None
MG  A 401 ( 3.1A)
None
 1.19A 4nkvC-4r7oA:
undetectable		 4nkvC-4r7oA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		3 / 3 GLU A  52
THR A 281
HIS A  43
 None
None
GOL  A 405 (-3.8A)
 0.85A 4q15A-4r7oA:
undetectable		 4q15A-4r7oA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		3 / 3 GLU A  52
THR A 281
HIS A  43
 None
None
GOL  A 405 (-3.8A)
 0.85A 4q15B-4r7oA:
undetectable		 4q15B-4r7oA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		3 / 3 LEU A  39
ASP A  67
TYR A  68
 None
 0.45A 4qc6B-4r7oA:
undetectable		 4qc6B-4r7oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		3 / 3 GLU A  52
THR A 281
HIS A  43
 None
None
GOL  A 405 (-3.8A)
 0.79A 4ydqB-4r7oA:
undetectable		 4ydqB-4r7oA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		5 / 10 ILE A 282
TRP A 212
GLY A 250
MET A 267
TYR A 266
 None
 1.37A 5lbtA-4r7oA:
undetectable
5lbtB-4r7oA:
undetectable		 5lbtA-4r7oA:
22.97
5lbtB-4r7oA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		4 / 4 GLN A  80
THR A 135
LEU A 170
LEU A 169
 None
 1.30A 5m5kB-4r7oA:
2.1		 5m5kB-4r7oA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		5 / 12 GLY A  45
MET A 186
VAL A 208
LEU A 210
ILE A  41
 None
None
None
GOL  A 405 ( 4.7A)
None
 1.16A 5vooD-4r7oA:
11.2		 5vooD-4r7oA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE
(Bacillus
anthracis) 		4 / 6 LEU A 195
TYR A 280
ASP A  72
GLU A 152
 None
GOL  A 405 (-3.6A)
MG  A 401 (-3.0A)
MG  A 401 ( 3.1A)
 1.16A 6djzC-4r7oA:
undetectable		 6djzC-4r7oA:
20.21