SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A 446
LEU A 432
TYR A 442
LEU A 455
LEU A 472
 None
 1.36A 1e7wA-4r7pA:
undetectable		 1e7wA-4r7pA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ALA A 480
ASP A 484
ILE A 498
ILE A 488
ILE A 486
 None
 0.94A 1hshC-4r7pA:
undetectable		 1hshC-4r7pA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 478
VAL A 460
LEU A 458
LEU A 402
THR A 398
 None
 0.96A 2aw1A-4r7pA:
undetectable		 2aw1A-4r7pA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 9 PHE A 446
LEU A 432
TYR A 442
LEU A 455
LEU A 472
 None
 1.15A 2bfmA-4r7pA:
1.7
2bfmD-4r7pA:
2.0		 2bfmA-4r7pA:
19.92
2bfmD-4r7pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_B_TOPB1290_1
(PTERIDINE REDUCTASE
1)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 9 PHE A 446
LEU A 432
TYR A 442
LEU A 455
LEU A 472
 None
 1.16A 2bfmB-4r7pA:
1.7
2bfmC-4r7pA:
1.6		 2bfmB-4r7pA:
19.92
2bfmC-4r7pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 8 PHE A 446
LEU A 432
TYR A 442
LEU A 455
 None
 0.89A 2bfpA-4r7pA:
undetectable		 2bfpA-4r7pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 8 PHE A 446
LEU A 432
TYR A 442
LEU A 455
 None
 1.03A 2bfpD-4r7pA:
undetectable		 2bfpD-4r7pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 108
ILE A 146
THR A 142
ILE A 263
LEU A 264
 None
 1.13A 2jn3A-4r7pA:
undetectable		 2jn3A-4r7pA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 393
LEU A 141
GLY A 414
GLN A 144
THR A 417
 None
 1.43A 2yhdA-4r7pA:
undetectable		 2yhdA-4r7pA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 7 LYS A  33
TYR A 193
ASN A 346
ALA A 228
 None
 1.44A 3frqB-4r7pA:
undetectable		 3frqB-4r7pA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		6 / 12 ALA A 492
LEU A 472
SER A 448
ILE A 449
SER A 406
LEU A 402
 None
 1.26A 3k2hB-4r7pA:
undetectable		 3k2hB-4r7pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 320
PHE A 324
LYS A 325
 None
 0.83A 3u88A-4r7pA:
undetectable		 3u88A-4r7pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_1
(MNMC2)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 4 GLU A 299
ASP A 349
ASP A  74
GLU A 351
 None
 1.20A 3vywB-4r7pA:
1.7		 3vywB-4r7pA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 10 VAL A 460
LEU A 458
LEU A 402
THR A 398
VAL A 430
 None
 1.00A 4e3hA-4r7pA:
undetectable		 4e3hA-4r7pA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ILE A 334
ALA A 338
GLU A 277
GLN A 297
 None
 0.98A 4g0uB-4r7pA:
undetectable		 4g0uB-4r7pA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 5 LEU A 383
GLY A 384
ILE A  92
LYS A  91
 None
 1.18A 4ma8C-4r7pA:
undetectable		 4ma8C-4r7pA:
11.53