SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN
(Parabacteroides
merdae) 		5 / 10 LEU A 187
LEU A 197
LEU A 204
GLU A 179
ALA A 168
 None
 1.36A 1ie4A-4r7sA:
undetectable
1ie4C-4r7sA:
undetectable		 1ie4A-4r7sA:
19.85
1ie4C-4r7sA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN
(Parabacteroides
merdae) 		4 / 7 LEU A 154
ILE A 153
PHE A 150
ILE A 169
 None
None
None
EDO  A 302 (-3.9A)
 0.94A 1oniB-4r7sA:
undetectable
1oniC-4r7sA:
undetectable		 1oniB-4r7sA:
18.29
1oniC-4r7sA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN
(Parabacteroides
merdae) 		5 / 12 GLY A  66
ARG A  99
ALA A 100
CYH A 132
ASP A 115
 None
None
None
EDO  A 307 ( 3.9A)
None
 1.09A 3keeA-4r7sA:
undetectable		 3keeA-4r7sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN
(Parabacteroides
merdae) 		4 / 8 GLU A 105
GLN A  69
GLY A  66
SER A  81
 None
 0.99A 4f93B-4r7sA:
undetectable		 4f93B-4r7sA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN
(Parabacteroides
merdae) 		4 / 7 GLU A 147
GLN A 148
ASN A 142
ILE A 138
 None
 1.17A 4ii8A-4r7sA:
undetectable		 4ii8A-4r7sA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN
(Parabacteroides
merdae) 		5 / 12 LEU A  62
LEU A  65
GLY A  66
GLN A  69
LEU A 102
 None
 0.88A 4ok1A-4r7sA:
undetectable		 4ok1A-4r7sA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN
(Parabacteroides
merdae) 		5 / 12 LEU A  62
LEU A  65
GLY A  66
GLN A  69
LEU A 102
 None
 0.86A 4olmA-4r7sA:
undetectable		 4olmA-4r7sA:
21.72