SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 GLU A1947
ALA A1949
SER A1932
 None
 0.69A 1errB-4r7yA:
undetectable		 1errB-4r7yA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 ALA A1731
VAL A1742
TRP A1741
 None
 0.81A 1grmA-4r7yA:
undetectable		 1grmA-4r7yA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 ALA A1731
VAL A1742
TRP A1741
 None
 0.81A 1grmB-4r7yA:
undetectable		 1grmB-4r7yA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 ALA A1731
VAL A1742
TRP A1741
 None
 0.85A 1jo3A-4r7yA:
undetectable		 1jo3A-4r7yA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 ALA A1731
VAL A1742
TRP A1741
 None
 0.85A 1jo3B-4r7yA:
undetectable		 1jo3B-4r7yA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 ALA A1731
VAL A1742
TRP A1741
 None
 0.87A 1jo4A-4r7yA:
undetectable		 1jo4A-4r7yA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 ALA A1731
VAL A1742
TRP A1741
 None
 0.87A 1jo4B-4r7yA:
undetectable		 1jo4B-4r7yA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		4 / 7 GLU A1951
MET A1938
PHE A1833
ALA A1281
 None
 1.34A 1linA-4r7yA:
0.4		 1linA-4r7yA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		4 / 8 LEU A1960
GLU A1957
TYR A1897
ILE A1920
 None
 0.98A 1qvtA-4r7yA:
undetectable		 1qvtA-4r7yA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 ARG A 110
ARG A 211
ILE A 107
 None
 0.63A 1uobA-4r7yA:
undetectable		 1uobA-4r7yA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 CYH A 171
CYH A 149
HIS A 144
 ZN  A2003 (-2.1A)
ZN  A2003 (-2.2A)
ZN  A2003 (-3.1A)
 0.71A 2iwkA-4r7yA:
undetectable		 2iwkA-4r7yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 CYH A 171
CYH A 149
HIS A 144
 ZN  A2003 (-2.1A)
ZN  A2003 (-2.2A)
ZN  A2003 (-3.1A)
 0.72A 2iwkB-4r7yA:
undetectable		 2iwkB-4r7yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 LEU A1748
ALA A1751
ILE A1349
ILE A1300
LEU A1304
 None
 1.19A 2jn3A-4r7yA:
undetectable		 2jn3A-4r7yA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		4 / 6 ARG A1317
ASP A1321
ILE A1322
GLU A1933
 None
 1.00A 2ya7A-4r7yA:
undetectable		 2ya7A-4r7yA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		4 / 6 ARG A1317
ASP A1321
ILE A1322
GLU A1933
 None
 1.05A 2ya7B-4r7yA:
undetectable		 2ya7B-4r7yA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		4 / 6 ARG A1317
ASP A1321
ILE A1322
GLU A1933
 None
 1.01A 2ya7C-4r7yA:
undetectable		 2ya7C-4r7yA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		4 / 6 ARG A1317
ASP A1321
ILE A1322
GLU A1933
 None
 1.02A 2ya7D-4r7yA:
undetectable		 2ya7D-4r7yA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		4 / 7 GLU A1957
TYR A1897
ARG A1900
SER A1904
 None
 1.19A 2zt7A-4r7yA:
undetectable		 2zt7A-4r7yA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 GLY A 102
LEU A  71
LEU A  74
VAL A  98
ILE A  47
 None
 1.02A 3adsB-4r7yA:
undetectable		 3adsB-4r7yA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 CYH A 171
CYH A 149
HIS A 144
 ZN  A2003 (-2.1A)
ZN  A2003 (-2.2A)
ZN  A2003 (-3.1A)
 0.57A 3dtuB-4r7yA:
undetectable		 3dtuB-4r7yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 CYH A 171
CYH A 149
HIS A 144
 ZN  A2003 (-2.1A)
ZN  A2003 (-2.2A)
ZN  A2003 (-3.1A)
 0.56A 3dtuD-4r7yA:
undetectable		 3dtuD-4r7yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 LEU A1748
GLY A1753
ILE A1781
LEU A1792
ARG A 230
 None
None
None
CL  A2005 ( 4.8A)
CL  A2005 (-3.9A)
 1.33A 3gyqA-4r7yA:
undetectable
3gyqB-4r7yA:
undetectable		 3gyqA-4r7yA:
21.46
3gyqB-4r7yA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 ALA A1281
LEU A1871
LEU A1272
LYS A1274
LEU A1940
 None
 1.14A 3ix9B-4r7yA:
undetectable		 3ix9B-4r7yA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 VAL A1341
LEU A1344
TYR A1755
LEU A1757
ILE A1875
 None
 1.13A 3kk6A-4r7yA:
undetectable		 3kk6A-4r7yA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 VAL A1341
LEU A1344
TYR A1755
LEU A1757
ILE A1875
 None
 1.16A 3kk6B-4r7yA:
undetectable		 3kk6B-4r7yA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		4 / 5 VAL A1341
LEU A1344
TYR A1755
ILE A1875
 None
 0.92A 3n8yB-4r7yA:
undetectable		 3n8yB-4r7yA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 9 ARG A1950
ILE A1953
ALA A1890
LEU A1928
VAL A1944
 None
 1.38A 3o01A-4r7yA:
undetectable
3o01B-4r7yA:
undetectable		 3o01A-4r7yA:
17.07
3o01B-4r7yA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 THR A  19
ILE A  31
LEU A  45
VAL A  98
ILE A  82
 None
 1.20A 3sp9A-4r7yA:
undetectable		 3sp9A-4r7yA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 ALA A1281
LEU A1871
LEU A1272
LYS A1274
LEU A1940
 None
 0.92A 3tq9A-4r7yA:
undetectable		 3tq9A-4r7yA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		4 / 5 SER A  50
ILE A  63
GLY A 102
PRO A 104
 None
 0.84A 3uboB-4r7yA:
undetectable		 3uboB-4r7yA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 ALA A1732
TRP A1741
VAL A1742
 None
 0.37A 4w9nC-4r7yA:
undetectable		 4w9nC-4r7yA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 LEU A1757
ALA A1348
LEU A1344
ASN A1343
ILE A1286
 None
 1.17A 4x1yB-4r7yA:
undetectable		 4x1yB-4r7yA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 ALA A1802
ASP A1762
LEU A1761
LEU A1325
ILE A1963
 None
 0.97A 4xi3B-4r7yA:
undetectable		 4xi3B-4r7yA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		4 / 7 ILE A1788
GLY A1740
THR A1738
LEU A 209
 None
 1.01A 5esmA-4r7yA:
undetectable		 5esmA-4r7yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 ARG A1879
HIS A1883
ARG A1937
 None
 1.17A 5iaoC-4r7yA:
undetectable		 5iaoC-4r7yA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		3 / 3 ARG A1879
HIS A1883
ARG A1937
 None
 1.17A 5iaoF-4r7yA:
undetectable		 5iaoF-4r7yA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 LEU A1871
TYR A1874
VAL A1283
ALA A1301
LEU A1302
 None
 1.08A 5ikqA-4r7yA:
undetectable		 5ikqA-4r7yA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 LEU A1871
TYR A1874
VAL A1283
ALA A1301
LEU A1302
 None
 1.09A 5ikqB-4r7yA:
1.4		 5ikqB-4r7yA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 12 ASP A1837
ILE A1836
PRO A1804
PHE A1809
ARG A1811
 None
 1.31A 5k7uA-4r7yA:
undetectable		 5k7uA-4r7yA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 11 ALA A1794
THR A1796
ALA A1745
GLY A1746
LEU A1825
 None
 1.11A 5lf7H-4r7yA:
undetectable
5lf7I-4r7yA:
undetectable		 5lf7H-4r7yA:
18.67
5lf7I-4r7yA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		5 / 11 ALA A1794
THR A1796
ALA A1745
GLY A1746
LEU A1825
 None
 1.13A 5lf7V-4r7yA:
undetectable
5lf7W-4r7yA:
undetectable		 5lf7V-4r7yA:
18.67
5lf7W-4r7yA:
15.82