SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		3 / 3 GLU A 895
ALA A 890
SER A 887
 None
 0.55A 1errB-4r7zA:
undetectable		 1errB-4r7zA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 ASN A 343
ALA A 348
LEU A 757
ALA A 800
ILE A 337
 None
 1.00A 1fk6A-4r7zA:
undetectable		 1fk6A-4r7zA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 10 LEU A 871
TYR A 874
VAL A 283
ALA A 301
LEU A 302
 None
 1.08A 1pxxA-4r7zA:
undetectable		 1pxxA-4r7zA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 871
TYR A 874
VAL A 283
ALA A 301
LEU A 302
 None
 1.08A 1pxxC-4r7zA:
2.0		 1pxxC-4r7zA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		4 / 5 LEU A 871
LEU A 304
LEU A 302
LEU A 344
 None
 1.05A 1yajD-4r7zA:
undetectable		 1yajD-4r7zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		3 / 3 LYS A 334
ASP A 820
ASN A 803
 ADP  A1001 ( 3.6A)
None
ADP  A1001 ( 4.7A)
 1.04A 2bm9A-4r7zA:
undetectable		 2bm9A-4r7zA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 VAL A 324
ILE A 322
GLY A 306
ILE A 875
ILE A 799
 None
 0.86A 2r5pC-4r7zA:
undetectable		 2r5pC-4r7zA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		4 / 5 VAL A 341
LEU A 344
TYR A 755
ILE A 875
 None
 1.00A 3n8yB-4r7zA:
undetectable		 3n8yB-4r7zA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 VAL A 798
ILE A 300
ARG A 828
LEU A 835
VAL A 327
 None
 1.48A 3oxzA-4r7zA:
undetectable		 3oxzA-4r7zA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 325
ALA A 801
LEU A 761
MET A 764
ILE A 772
 None
 1.13A 3ut5B-4r7zA:
undetectable		 3ut5B-4r7zA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 325
ALA A 801
LEU A 761
MET A 764
ILE A 772
 None
 1.11A 3ut5D-4r7zA:
undetectable		 3ut5D-4r7zA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		3 / 3 LYS A 753
TYR A 755
ARG A 347
 None
 1.24A 4gc9A-4r7zA:
undetectable		 4gc9A-4r7zA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 757
ALA A 348
LEU A 344
ASN A 343
ILE A 300
 None
 1.12A 4o2bB-4r7zA:
undetectable		 4o2bB-4r7zA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 871
TYR A 874
VAL A 283
ALA A 301
LEU A 302
 None
 1.01A 4rrxA-4r7zA:
undetectable		 4rrxA-4r7zA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 871
TYR A 874
VAL A 283
ALA A 301
LEU A 302
 None
 0.98A 4rrxB-4r7zA:
undetectable		 4rrxB-4r7zA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 LEU A 821
GLY A 328
LEU A 835
LEU A 761
ALA A 800
 None
 1.14A 4wnuA-4r7zA:
undetectable		 4wnuA-4r7zA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 325
LEU A 338
LEU A 761
MET A 764
ILE A 772
 None
 1.09A 4x1iD-4r7zA:
undetectable		 4x1iD-4r7zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 325
LEU A 338
LEU A 761
MET A 764
ILE A 772
 None
 1.05A 4x1yD-4r7zA:
undetectable		 4x1yD-4r7zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 LEU A 325
LEU A 338
LEU A 761
MET A 764
ILE A 772
 None
 1.04A 4x20D-4r7zA:
undetectable		 4x20D-4r7zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 871
TYR A 874
VAL A 283
ALA A 301
LEU A 302
 None
 1.02A 5ikqA-4r7zA:
undetectable		 5ikqA-4r7zA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 871
TYR A 874
VAL A 283
ALA A 301
LEU A 302
 None
 1.03A 5ikqB-4r7zA:
undetectable		 5ikqB-4r7zA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 757
ALA A 348
LEU A 344
ASN A 343
ILE A 300
 None
 1.10A 5itzB-4r7zA:
undetectable		 5itzB-4r7zA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 LEU A 325
LEU A 338
LEU A 761
MET A 764
ILE A 772
 None
 1.14A 5nm5B-4r7zA:
undetectable		 5nm5B-4r7zA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 ASP A 321
ARG A 879
PRO A 346
ILE A 875
HIS A 323
 None
 1.40A 5uhgC-4r7zA:
undetectable		 5uhgC-4r7zA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 ALA A 345
VAL A 324
MET A 938
GLY A 299
LEU A 835
 None
 1.09A 5xxiA-4r7zA:
undetectable		 5xxiA-4r7zA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 ALA A 345
VAL A 324
MET A 938
LEU A 835
LEU A 326
 None
 1.06A 5xxiA-4r7zA:
undetectable		 5xxiA-4r7zA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 10 ILE A 866
ILE A 322
ALA A 303
LEU A 304
ALA A 345
 None
 1.47A 5zjiB-4r7zA:
undetectable		 5zjiB-4r7zA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 4r7z CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 ASP A 321
ARG A 879
PRO A 346
ILE A 875
HIS A 323
 None
 1.34A 6ccvC-4r7zA:
undetectable		 6ccvC-4r7zA:
15.12