SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		7 / 12 HIS A  56
HIS A  58
ASP A  60
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.87A 1a4lA-4r85A:
22.6		 1a4lA-4r85A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 12 ASP A  60
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.73A 1a4lB-4r85A:
22.8		 1a4lB-4r85A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 12 HIS A  58
ASP A  60
HIS A 209
GLU A 212
ASP A 308
 FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 2.8A)
 0.89A 1a4lB-4r85A:
22.8		 1a4lB-4r85A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		7 / 12 HIS A  56
HIS A  58
ASP A  60
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.85A 1a4lC-4r85A:
22.7		 1a4lC-4r85A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		6 / 12 HIS A  58
ASP A  60
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.91A 1a4lD-4r85A:
22.6		 1a4lD-4r85A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 8 HIS A  58
HIS A  56
HIS A 117
HIS A 241
 FE2  A 502 ( 3.5A)
FE2  A 502 (-3.4A)
None
FE2  A 502 ( 3.7A)
 0.96A 1azmA-4r85A:
undetectable		 1azmA-4r85A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 8 HIS A  58
HIS A  56
HIS A 117
HIS A 241
 FE2  A 502 ( 3.5A)
FE2  A 502 (-3.4A)
None
FE2  A 502 ( 3.7A)
 0.78A 1bzmA-4r85A:
undetectable		 1bzmA-4r85A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_C_BEZC602_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 9 PRO A 313
ASP A  60
SER A 309
HIS A  58
TRP A  83
 None
None
17E  A 501 (-3.2A)
FE2  A 502 ( 3.5A)
None
 1.46A 1gxsC-4r85A:
undetectable
1gxsD-4r85A:
0.8		 1gxsC-4r85A:
23.06
1gxsD-4r85A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 10 LEU A 144
ALA A 138
GLU A 137
LEU A 100
ILE A  57
 None
 1.25A 1pcgA-4r85A:
undetectable		 1pcgA-4r85A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 8 THR A 116
LEU A 144
VAL A 134
ASP A  60
 None
 1.20A 1uyuA-4r85A:
undetectable		 1uyuA-4r85A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 ILE A 301
LEU A 296
ARG A 229
LEU A 221
 None
 0.96A 1v54N-4r85A:
undetectable
1v54W-4r85A:
undetectable		 1v54N-4r85A:
22.06
1v54W-4r85A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 LEU A 128
ASP A 122
THR A 121
HIS A 180
 None
 1.17A 1v55C-4r85A:
undetectable
1v55N-4r85A:
undetectable
1v55P-4r85A:
undetectable		 1v55C-4r85A:
20.00
1v55N-4r85A:
22.06
1v55P-4r85A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		3 / 3 HIS A 117
ASP A 312
ASN A  71
 None
17E  A 501 ( 4.4A)
None
 0.69A 1wg8B-4r85A:
undetectable		 1wg8B-4r85A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 10 HIS A  56
HIS A 241
HIS A 209
THR A 116
ASP A 312
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
None
17E  A 501 ( 4.4A)
 1.45A 2dttD-4r85A:
undetectable
2dttF-4r85A:
undetectable		 2dttD-4r85A:
14.32
2dttF-4r85A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 ILE A 301
LEU A 296
ARG A 229
LEU A 221
 None
 0.98A 2dyrN-4r85A:
undetectable
2dyrW-4r85A:
undetectable		 2dyrN-4r85A:
22.06
2dyrW-4r85A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 6 ARG A 395
VAL A 114
LEU A 144
ALA A 139
 None
 1.05A 2e1qA-4r85A:
undetectable		 2e1qA-4r85A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 6 ARG A 395
VAL A 114
LEU A 144
ALA A 139
 None
 1.05A 2e1qC-4r85A:
undetectable		 2e1qC-4r85A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A 241
HIS A 209
HIS A 117
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
None
 1.20A 2fqeA-4r85A:
undetectable		 2fqeA-4r85A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A 209
HIS A 117
HIS A  56
HIS A 241
 FE2  A 502 ( 3.4A)
None
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
 1.34A 2fqeA-4r85A:
undetectable		 2fqeA-4r85A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		6 / 12 HIS A  58
ASP A  60
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.64A 2pgfA-4r85A:
23.1		 2pgfA-4r85A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		6 / 12 HIS A  58
ASP A 119
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.92A 2pgfA-4r85A:
23.1		 2pgfA-4r85A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		7 / 12 HIS A  56
HIS A  58
ASP A  60
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.64A 2pgrA-4r85A:
23.2		 2pgrA-4r85A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		7 / 12 HIS A  56
HIS A  58
ASP A 119
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.89A 2pgrA-4r85A:
23.2		 2pgrA-4r85A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 6 ARG A  86
THR A  62
ALA A  61
ARG A  98
 None
 1.05A 2ql8A-4r85A:
undetectable
2ql8B-4r85A:
undetectable		 2ql8A-4r85A:
15.79
2ql8B-4r85A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 176
LEU A  76
GLN A 151
SER A 309
ASP A  60
 None
17E  A 501 (-4.9A)
17E  A 501 (-2.9A)
17E  A 501 (-3.2A)
None
 1.28A 2vqyA-4r85A:
0.2		 2vqyA-4r85A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 177
LEU A  76
GLN A 151
SER A 309
ASP A  60
 None
17E  A 501 (-4.9A)
17E  A 501 (-2.9A)
17E  A 501 (-3.2A)
None
 1.43A 2vqyA-4r85A:
0.2		 2vqyA-4r85A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		3 / 3 GLU A 273
HIS A 209
GLU A 212
 17E  A 501 (-4.3A)
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
 0.82A 2x45B-4r85A:
undetectable		 2x45B-4r85A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		3 / 3 GLU A 273
HIS A 209
GLU A 212
 17E  A 501 (-4.3A)
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
 0.81A 2x45C-4r85A:
undetectable		 2x45C-4r85A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 11 ILE A  57
THR A  62
THR A 116
VAL A 114
ILE A 103
 None
 1.26A 3kpcA-4r85A:
undetectable		 3kpcA-4r85A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		3 / 3 HIS A 209
HIS A  56
HIS A  58
 FE2  A 502 ( 3.4A)
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
 0.47A 3qpkA-4r85A:
undetectable		 3qpkA-4r85A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		3 / 3 HIS A 209
HIS A  56
HIS A  58
 FE2  A 502 ( 3.4A)
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
 0.48A 3qpkB-4r85A:
undetectable		 3qpkB-4r85A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 6 ALA A  99
ILE A 103
LEU A  59
ALA A 130
 None
 0.80A 3r9sC-4r85A:
2.2		 3r9sC-4r85A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 8 THR A 349
PRO A  51
GLY A 110
PHE A  52
SER A 393
 None
 1.41A 3tzfB-4r85A:
5.8		 3tzfB-4r85A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 11 GLY A 160
VAL A 175
GLY A 176
GLY A 177
ILE A 178
 None
 0.80A 3ufnA-4r85A:
undetectable		 3ufnA-4r85A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 ARG A 395
VAL A 114
LEU A 144
ALA A 139
 None
 1.03A 3uniA-4r85A:
undetectable		 3uniA-4r85A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 8 HIS A  58
HIS A  56
HIS A 117
HIS A 241
 FE2  A 502 ( 3.5A)
FE2  A 502 (-3.4A)
None
FE2  A 502 ( 3.7A)
 1.04A 3w6hA-4r85A:
undetectable		 3w6hA-4r85A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A  76
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 17E  A 501 (-4.9A)
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.66A 4aqlA-4r85A:
31.5		 4aqlA-4r85A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A  58
HIS A 241
HIS A 209
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
 0.97A 4ef3A-4r85A:
undetectable		 4ef3A-4r85A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 131
ALA A 138
ASP A 140
GLY A 104
THR A 116
 None
 1.03A 4njuA-4r85A:
undetectable		 4njuA-4r85A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 131
ALA A 138
ASP A 140
GLY A 104
THR A 116
 None
 1.03A 4njuC-4r85A:
undetectable		 4njuC-4r85A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 11 HIS A 241
ASP A 308
GLU A 212
GLY A  79
HIS A  58
 FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
17E  A 501 (-2.9A)
None
FE2  A 502 ( 3.5A)
 0.91A 4pqaA-4r85A:
undetectable		 4pqaA-4r85A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 11 GLY A 176
HIS A 209
TRP A 314
GLN A 151
ASP A 119
 None
FE2  A 502 ( 3.4A)
17E  A 501 (-3.4A)
17E  A 501 (-2.9A)
None
 1.30A 4qc6A-4r85A:
0.0		 4qc6A-4r85A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 176
GLU A 212
TRP A 314
GLN A 151
ASP A 119
 None
17E  A 501 (-2.9A)
17E  A 501 (-3.4A)
17E  A 501 (-2.9A)
None
 1.29A 4qc6B-4r85A:
0.8		 4qc6B-4r85A:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 12 HIS A  58
ILE A  80
GLU A 273
ASP A 308
SER A 309
 FE2  A 502 ( 3.5A)
None
17E  A 501 (-4.3A)
FE2  A 502 ( 2.8A)
17E  A 501 (-3.2A)
 1.45A 4r88A-4r85A:
72.2		 4r88A-4r85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		12 / 12 HIS A  58
LEU A  76
PHE A 149
GLN A 151
ILE A 178
HIS A 209
HIS A 241
GLU A 273
LEU A 277
ASP A 308
SER A 309
TRP A 314
 FE2  A 502 ( 3.5A)
17E  A 501 (-4.9A)
17E  A 501 (-4.9A)
17E  A 501 (-2.9A)
None
FE2  A 502 ( 3.4A)
FE2  A 502 ( 3.7A)
17E  A 501 (-4.3A)
None
FE2  A 502 ( 2.8A)
17E  A 501 (-3.2A)
17E  A 501 (-3.4A)
 0.21A 4r88A-4r85A:
72.2		 4r88A-4r85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A  76
HIS A 209
ASP A 308
SER A 309
TRP A 314
 17E  A 501 (-4.9A)
FE2  A 502 ( 3.4A)
FE2  A 502 ( 2.8A)
17E  A 501 (-3.2A)
17E  A 501 (-3.4A)
 1.31A 4r88A-4r85A:
72.2		 4r88A-4r85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		12 / 12 HIS A  58
LEU A  76
PHE A 149
GLN A 151
ILE A 178
HIS A 209
GLU A 212
GLU A 273
LEU A 277
ASP A 308
SER A 309
TRP A 314
 FE2  A 502 ( 3.5A)
17E  A 501 (-4.9A)
17E  A 501 (-4.9A)
17E  A 501 (-2.9A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
17E  A 501 (-4.3A)
None
FE2  A 502 ( 2.8A)
17E  A 501 (-3.2A)
17E  A 501 (-3.4A)
 0.14A 4r88B-4r85A:
72.6		 4r88B-4r85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		12 / 12 HIS A  58
LEU A  76
PHE A 149
GLN A 151
ILE A 178
HIS A 209
GLU A 212
GLU A 273
LEU A 277
ASP A 308
SER A 309
TRP A 314
 FE2  A 502 ( 3.5A)
17E  A 501 (-4.9A)
17E  A 501 (-4.9A)
17E  A 501 (-2.9A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
17E  A 501 (-4.3A)
None
FE2  A 502 ( 2.8A)
17E  A 501 (-3.2A)
17E  A 501 (-3.4A)
 0.16A 4r88C-4r85A:
72.0		 4r88C-4r85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		12 / 12 HIS A  58
LEU A  76
PHE A 149
GLN A 151
ILE A 178
HIS A 209
GLU A 212
GLU A 273
LEU A 277
ASP A 308
SER A 309
TRP A 314
 FE2  A 502 ( 3.5A)
17E  A 501 (-4.9A)
17E  A 501 (-4.9A)
17E  A 501 (-2.9A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
17E  A 501 (-4.3A)
None
FE2  A 502 ( 2.8A)
17E  A 501 (-3.2A)
17E  A 501 (-3.4A)
 0.15A 4r88D-4r85A:
71.7		 4r88D-4r85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		12 / 12 HIS A  58
LEU A  76
PHE A 149
GLN A 151
ILE A 178
HIS A 209
GLU A 212
GLU A 273
LEU A 277
ASP A 308
SER A 309
TRP A 314
 FE2  A 502 ( 3.5A)
17E  A 501 (-4.9A)
17E  A 501 (-4.9A)
17E  A 501 (-2.9A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
17E  A 501 (-4.3A)
None
FE2  A 502 ( 2.8A)
17E  A 501 (-3.2A)
17E  A 501 (-3.4A)
 0.16A 4r88E-4r85A:
72.3		 4r88E-4r85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		12 / 12 HIS A  58
LEU A  76
PHE A 149
GLN A 151
ILE A 178
HIS A 209
GLU A 212
GLU A 273
LEU A 277
ASP A 308
SER A 309
TRP A 314
 FE2  A 502 ( 3.5A)
17E  A 501 (-4.9A)
17E  A 501 (-4.9A)
17E  A 501 (-2.9A)
None
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
17E  A 501 (-4.3A)
None
FE2  A 502 ( 2.8A)
17E  A 501 (-3.2A)
17E  A 501 (-3.4A)
 0.18A 4r88F-4r85A:
71.8		 4r88F-4r85A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 8 ASP A 122
THR A 121
HIS A 180
LEU A 128
 None
 1.10A 5b1bA-4r85A:
undetectable
5b1bC-4r85A:
undetectable
5b1bP-4r85A:
undetectable		 5b1bA-4r85A:
22.06
5b1bC-4r85A:
20.00
5b1bP-4r85A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 ILE A 301
LEU A 296
ARG A 229
LEU A 221
 None
 0.96A 5b1bA-4r85A:
undetectable
5b1bJ-4r85A:
undetectable		 5b1bA-4r85A:
22.06
5b1bJ-4r85A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 ILE A 301
LEU A 296
ARG A 229
LEU A 221
 None
 0.99A 5iy5A-4r85A:
undetectable
5iy5J-4r85A:
undetectable		 5iy5A-4r85A:
22.06
5iy5J-4r85A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 7 VAL A 384
LEU A 326
GLU A 382
ALA A 383
LEU A 341
 None
 1.41A 5jq7A-4r85A:
undetectable		 5jq7A-4r85A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 8 LEU A 144
LEU A 100
ILE A  90
THR A  95
 None
 0.98A 5ljbA-4r85A:
undetectable		 5ljbA-4r85A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A 241
HIS A 209
HIS A 117
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
None
 1.19A 5mi2A-4r85A:
undetectable		 5mi2A-4r85A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A 241
HIS A 209
HIS A 117
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
None
 1.20A 5miaA-4r85A:
undetectable		 5miaA-4r85A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A 241
HIS A 209
HIS A 117
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
None
 1.20A 5mibA-4r85A:
undetectable		 5mibA-4r85A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A 241
HIS A 209
HIS A 117
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
None
 1.19A 5micA-4r85A:
undetectable		 5micA-4r85A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A 241
HIS A 209
HIS A 117
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
None
 1.19A 5midA-4r85A:
undetectable		 5midA-4r85A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A 241
HIS A 209
HIS A 117
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
None
 1.19A 5mieA-4r85A:
undetectable		 5mieA-4r85A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		3 / 3 HIS A 209
HIS A  56
HIS A  58
 FE2  A 502 ( 3.4A)
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
 0.42A 5migA-4r85A:
undetectable		 5migA-4r85A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A 241
HIS A 209
HIS A 117
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
None
 1.19A 5migA-4r85A:
undetectable		 5migA-4r85A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 5 CYH A 270
ILE A 268
HIS A 209
HIS A  58
 None
None
FE2  A 502 ( 3.4A)
FE2  A 502 ( 3.5A)
 1.19A 5ocsC-4r85A:
8.4		 5ocsC-4r85A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 8 ASP A 122
THR A 121
HIS A 180
LEU A 128
 None
 1.19A 5wauA-4r85A:
undetectable
5wauC-4r85A:
undetectable
5wauc-4r85A:
undetectable		 5wauA-4r85A:
22.06
5wauC-4r85A:
20.00
5wauc-4r85A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 LEU A 128
ASP A 122
THR A 121
HIS A 180
 None
 1.18A 5wauC-4r85A:
undetectable
5waua-4r85A:
undetectable
5wauc-4r85A:
undetectable		 5wauC-4r85A:
20.00
5waua-4r85A:
22.06
5wauc-4r85A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 ASP A 122
THR A 121
HIS A 180
LEU A 128
 None
 1.12A 5x1bA-4r85A:
undetectable
5x1bC-4r85A:
undetectable
5x1bP-4r85A:
undetectable		 5x1bA-4r85A:
22.06
5x1bC-4r85A:
20.00
5x1bP-4r85A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 ASP A 122
THR A 121
HIS A 180
LEU A 128
 None
 1.17A 5x1fA-4r85A:
undetectable
5x1fC-4r85A:
undetectable
5x1fP-4r85A:
undetectable		 5x1fA-4r85A:
22.06
5x1fC-4r85A:
20.00
5x1fP-4r85A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 ILE A 301
LEU A 296
ARG A 229
LEU A 221
 None
 0.94A 5xdqA-4r85A:
undetectable
5xdqJ-4r85A:
undetectable		 5xdqA-4r85A:
22.06
5xdqJ-4r85A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 VAL A 390
LEU A 375
LEU A  47
ASP A 380
 None
 1.29A 5xv7A-4r85A:
undetectable		 5xv7A-4r85A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 5 HIS A  56
HIS A  58
PHE A 149
HIS A 117
HIS A 209
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
17E  A 501 (-4.9A)
None
FE2  A 502 ( 3.4A)
 1.35A 5zrdB-4r85A:
undetectable		 5zrdB-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 5 HIS A 209
HIS A 241
HIS A  56
HIS A  58
 FE2  A 502 ( 3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
 1.04A 5zrdB-4r85A:
undetectable		 5zrdB-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A  58
HIS A 117
HIS A 209
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
 1.13A 5zrdC-4r85A:
undetectable		 5zrdC-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A 209
HIS A 241
HIS A  56
HIS A  58
 FE2  A 502 ( 3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
 1.01A 5zrdC-4r85A:
undetectable		 5zrdC-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A  58
HIS A 117
HIS A 209
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
 1.09A 5zrdD-4r85A:
undetectable		 5zrdD-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A  56
HIS A  58
HIS A 209
HIS A 241
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
FE2  A 502 ( 3.4A)
FE2  A 502 ( 3.7A)
 1.17A 5zrdD-4r85A:
undetectable		 5zrdD-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 4 HIS A 209
HIS A 241
HIS A  56
HIS A  58
 FE2  A 502 ( 3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
 1.01A 5zrdD-4r85A:
undetectable		 5zrdD-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		5 / 10 ARG A  98
LEU A 128
LEU A 131
VAL A 118
TRP A  83
 None
 1.38A 6g2pB-4r85A:
undetectable		 6g2pB-4r85A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		7 / 12 HIS A  58
ASP A  60
LEU A  76
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 FE2  A 502 ( 3.5A)
None
17E  A 501 (-4.9A)
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.68A 6n91A-4r85A:
24.1		 6n91A-4r85A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		7 / 12 HIS A  58
ASP A  60
LEU A  76
HIS A 209
GLU A 212
HIS A 241
ASP A 308
 FE2  A 502 ( 3.5A)
None
17E  A 501 (-4.9A)
FE2  A 502 ( 3.4A)
17E  A 501 (-2.9A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 2.8A)
 0.67A 6n91B-4r85A:
24.1		 6n91B-4r85A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4r85 CYTOSINE DEAMINASE
(Klebsiella
pneumoniae) 		4 / 7 ASP A 122
THR A 121
HIS A 180
LEU A 128
 None
 1.13A 6nmfA-4r85A:
undetectable
6nmfC-4r85A:
undetectable
6nmfP-4r85A:
undetectable		 6nmfA-4r85A:
22.06
6nmfC-4r85A:
20.00
6nmfP-4r85A:
20.00