SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r86'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		4 / 7 ILE A 291
TYR A 289
PHE A 108
PHE A 283
 None
 1.17A 1e71M-4r86A:
undetectable		 1e71M-4r86A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		4 / 7 ILE A 291
TYR A 289
PHE A 108
PHE A 283
 None
 1.19A 1e72M-4r86A:
undetectable		 1e72M-4r86A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 9 GLY A 254
PHE A 108
THR A 105
ILE A 141
ASN A 102
 None
 1.50A 2a8tA-4r86A:
0.0		 2a8tA-4r86A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		4 / 5 GLN A  53
GLN A  47
ASP A 242
THR A 105
 None
 1.28A 3bwcB-4r86A:
undetectable		 3bwcB-4r86A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 12 GLN A 176
VAL A 169
GLY A 229
ALA A 232
LEU A 154
 None
 1.01A 3ln1A-4r86A:
undetectable		 3ln1A-4r86A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 12 GLN A 176
VAL A 169
GLY A 229
ALA A 232
LEU A 154
 None
 1.00A 3ln1B-4r86A:
undetectable		 3ln1B-4r86A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 12 GLN A 176
VAL A 169
GLY A 229
ALA A 232
LEU A 154
 None
 1.01A 3ln1D-4r86A:
undetectable		 3ln1D-4r86A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		4 / 6 VAL A  30
VAL A   9
VAL A  93
ILE A  56
 None
 0.99A 3mssD-4r86A:
undetectable		 3mssD-4r86A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		3 / 3 LYS A 258
SER A  49
GLN A  47
 None
 1.10A 3si7A-4r86A:
undetectable		 3si7A-4r86A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 11 LEU A 154
ILE A 180
ILE A 173
VAL A 169
LEU A 217
 None
 1.15A 3w67A-4r86A:
undetectable		 3w67A-4r86A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 12 LEU A 154
ILE A 180
ILE A 173
VAL A 169
LEU A 217
 None
 1.05A 3w67B-4r86A:
undetectable		 3w67B-4r86A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		4 / 6 GLY A 137
ASN A 136
ASN A 264
GLU A 265
 None
 1.01A 3zqtA-4r86A:
undetectable		 3zqtA-4r86A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 12 PHE A 108
LEU A 132
PRO A 131
LEU A 276
ILE A 106
 None
 0.94A 4m2xA-4r86A:
undetectable		 4m2xA-4r86A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		3 / 3 SER A  59
MET A  42
ASP A  65
 None
 0.82A 4mm4B-4r86A:
undetectable		 4mm4B-4r86A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 12 ALA A 252
LEU A 287
ILE A 128
LEU A 276
ILE A 106
 None
 1.14A 4nx6A-4r86A:
undetectable		 4nx6A-4r86A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 12 ALA A 252
LEU A 287
ILE A 128
LEU A 276
ILE A 106
 None
 1.12A 4nx7A-4r86A:
undetectable		 4nx7A-4r86A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		3 / 3 ASN A 201
ASP A 142
ASP A 100
 None
 0.68A 4obwD-4r86A:
undetectable		 4obwD-4r86A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 12 GLN A 176
VAL A 169
GLY A 229
ALA A 232
LEU A 154
 None
 1.03A 5jw1A-4r86A:
undetectable		 5jw1A-4r86A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 12 GLN A 176
VAL A 169
GLY A 229
ALA A 232
LEU A 154
 None
 0.98A 5kirA-4r86A:
undetectable		 5kirA-4r86A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 12 GLN A 176
VAL A 169
GLY A 229
ALA A 232
LEU A 154
 None
 0.98A 5kirB-4r86A:
undetectable		 5kirB-4r86A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		5 / 9 PRO A  85
MET A  81
VAL A  27
LEU A  23
ILE A  56
 None
 1.48A 5tixA-4r86A:
undetectable		 5tixA-4r86A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP
(Salmonella
enterica) 		4 / 4 PRO A 131
LEU A 279
VAL A 135
ARG A 134
 None
 1.39A 6fgdA-4r86A:
undetectable		 6fgdA-4r86A:
21.18