SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 474
GLY A 388
SER A 392
GLY A 395
LEU A 396
 None
 1.13A 1fe2A-4r89A:
undetectable		 1fe2A-4r89A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 263
SER A 285
ILE A 295
ALA A 294
ALA A 266
 None
 1.16A 1jb0B-4r89A:
undetectable		 1jb0B-4r89A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 262
SER A 285
TYR A 282
LEU A 281
 None
 1.28A 1xz1A-4r89A:
undetectable		 1xz1A-4r89A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 262
SER A 285
TYR A 282
LEU A 281
 None
 1.27A 1xz3A-4r89A:
undetectable		 1xz3A-4r89A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 490
ARG A 544
PHE A 540
 None
 1.49A 1zeaH-4r89A:
undetectable
1zeaL-4r89A:
undetectable		 1zeaH-4r89A:
15.81
1zeaL-4r89A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 487
PRO A 506
VAL A 385
GLY A 388
 None
 0.94A 2qd5A-4r89A:
undetectable		 2qd5A-4r89A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 487
PRO A 506
VAL A 385
GLY A 388
 None
 1.01A 2qd5B-4r89A:
undetectable		 2qd5B-4r89A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 310
ALA A 314
GLU A 323
LEU A 331
LEU A 327
 None
 1.22A 3erdA-4r89A:
undetectable		 3erdA-4r89A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 237
PRO A 236
LEU A 240
ARG A 228
 None
 1.28A 3hcoA-4r89A:
undetectable		 3hcoA-4r89A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 263
SER A 285
ILE A 295
ALA A 294
ALA A 266
 None
 1.15A 3pcqB-4r89A:
undetectable		 3pcqB-4r89A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 409
ASP A 420
PHE A 426
SER A 462
ILE A 402
 None
 1.23A 3qgtB-4r89A:
undetectable		 3qgtB-4r89A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 491
ARG A 493
TRP A 490
LEU A 494
 None
 1.01A 4rkuA-4r89A:
undetectable
4rkuJ-4r89A:
undetectable		 4rkuA-4r89A:
21.35
4rkuJ-4r89A:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 491
ARG A 493
TRP A 490
LEU A 494
 None
 1.02A 4xk8A-4r89A:
undetectable		 4xk8A-4r89A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 310
ALA A 314
GLU A 323
LEU A 331
LEU A 327
 None
 1.20A 4zn7A-4r89A:
undetectable		 4zn7A-4r89A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 310
ALA A 314
GLU A 323
LEU A 331
LEU A 327
 None
 1.22A 4zn7B-4r89A:
undetectable		 4zn7B-4r89A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 262
SER A 286
PRO A 288
GLU A 323
 None
 1.21A 5b8iA-4r89A:
undetectable		 5b8iA-4r89A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A  37
ILE A  33
GLY A 181
PHE A 180
 None
 0.93A 5kmdC-4r89A:
undetectable
5kmdD-4r89A:
undetectable		 5kmdC-4r89A:
16.64
5kmdD-4r89A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 255
LEU A 254
ARG A 257
ARG A 258
 None
 1.24A 5l6eA-4r89A:
undetectable
5l6eB-4r89A:
undetectable		 5l6eA-4r89A:
16.88
5l6eB-4r89A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 263
SER A 285
ILE A 295
ALA A 294
ALA A 266
 None
 1.13A 5oy02-4r89A:
undetectable		 5oy02-4r89A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r89 UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 258
LEU A 262
GLN A 264
PHE A 263
 None
 1.20A 6nmpP-4r89A:
undetectable
6nmpW-4r89A:
undetectable		 6nmpP-4r89A:
18.96
6nmpW-4r89A:
9.23