SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 THR A 161
GLY A 105
SER A 106
ALA A 187
ALA A 103
 None
 1.28A 1nw5A-4r8eA:
undetectable		 1nw5A-4r8eA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		4 / 6 ARG A 249
ALA A 246
ILE A 177
GLU A 242
 None
 1.09A 1oniB-4r8eA:
undetectable
1oniC-4r8eA:
undetectable		 1oniB-4r8eA:
16.42
1oniC-4r8eA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		4 / 7 ILE A 177
GLU A 242
ARG A 249
ALA A 246
 None
 1.11A 1oniD-4r8eA:
undetectable
1oniE-4r8eA:
undetectable		 1oniD-4r8eA:
16.42
1oniE-4r8eA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 10 ALA A 235
VAL A 348
HIS A 303
HIS A 340
THR A 338
 None
 1.01A 1r55A-4r8eA:
undetectable		 1r55A-4r8eA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		4 / 4 THR A 305
GLY A 402
ASP A 265
ALA A 279
 None
 1.19A 1sg9A-4r8eA:
undetectable		 1sg9A-4r8eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		6 / 12 ILE A 170
GLY A 166
GLY A 343
ILE A 159
VAL A 348
ALA A 190
 None
 1.32A 1sg9B-4r8eA:
undetectable		 1sg9B-4r8eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ILE A 177
LEU A 240
HIS A 172
ALA A 182
GLY A 101
 None
 1.29A 2a58A-4r8eA:
undetectable
2a58B-4r8eA:
undetectable		 2a58A-4r8eA:
17.63
2a58B-4r8eA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ILE A 177
LEU A 240
HIS A 172
ALA A 182
GLY A 101
 None
 1.29A 2a58D-4r8eA:
undetectable
2a58E-4r8eA:
undetectable		 2a58D-4r8eA:
17.63
2a58E-4r8eA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 MET A 238
ALA A 187
VAL A   5
GLY A 188
ILE A 170
 None
 1.28A 2dcfA-4r8eA:
undetectable		 2dcfA-4r8eA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 11 GLY A 304
HIS A 303
LEU A 342
GLY A 339
GLU A 349
 None
 1.39A 2fn1A-4r8eA:
undetectable		 2fn1A-4r8eA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		3 / 3 ASP A 227
ARG A 226
ARG A 220
 None
 1.00A 2j9dA-4r8eA:
undetectable
2j9dC-4r8eA:
undetectable		 2j9dA-4r8eA:
14.29
2j9dC-4r8eA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		6 / 12 ALA A 235
GLY A 188
GLY A 236
ILE A 142
VAL A 167
GLY A 346
 None
 1.46A 2qe6A-4r8eA:
undetectable		 2qe6A-4r8eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		3 / 3 GLN A  31
THR A 334
TRP A  24
 None
 1.07A 2rctA-4r8eA:
undetectable		 2rctA-4r8eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		4 / 7 THR A 195
GLY A 198
PHE A 202
ILE A 108
 None
 0.84A 2y7wC-4r8eA:
undetectable		 2y7wC-4r8eA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 MET A 238
ALA A 187
VAL A   5
GLY A 188
ILE A 170
 None
 1.28A 3a65A-4r8eA:
undetectable		 3a65A-4r8eA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		4 / 4 GLY A 343
GLY A 189
GLY A 105
GLY A 166
 None
 0.65A 3bogC-4r8eA:
undetectable		 3bogC-4r8eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		4 / 4 GLY A 166
GLY A 189
GLY A 105
GLY A 188
 None
 0.65A 3bogD-4r8eA:
undetectable		 3bogD-4r8eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 GLY A 105
GLY A 166
ALA A 160
THR A 161
ALA A 187
 None
 1.09A 3g8bA-4r8eA:
undetectable		 3g8bA-4r8eA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 MET A 390
VAL A 318
ILE A 300
ASN A 301
GLU A 314
 None
 1.34A 3jayA-4r8eA:
1.1		 3jayA-4r8eA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 MET A 390
VAL A 318
ILE A 300
ASN A 301
GLU A 314
 None
 1.30A 3jb2A-4r8eA:
undetectable		 3jb2A-4r8eA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 MET A 390
VAL A 318
ILE A 300
ASN A 301
GLU A 314
 None
 1.26A 3jb3A-4r8eA:
undetectable		 3jb3A-4r8eA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 GLY A  30
VAL A 230
GLY A  33
ALA A 217
ALA A 218
 None
 1.10A 3keeB-4r8eA:
undetectable		 3keeB-4r8eA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 GLY A 234
GLY A 232
ASP A 233
GLU A 349
ALA A 344
 None
 1.18A 3t7sA-4r8eA:
undetectable		 3t7sA-4r8eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 GLY A 234
GLY A 232
ASP A 233
GLU A 349
ALA A 344
 None
 1.20A 3t7sB-4r8eA:
undetectable		 3t7sB-4r8eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 11 GLY A 189
ALA A 345
LEU A 342
GLY A 107
ALA A  46
 None
 1.19A 4l6v1-4r8eA:
undetectable
4l6v6-4r8eA:
undetectable		 4l6v1-4r8eA:
20.42
4l6v6-4r8eA:
15.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		10 / 12 GLY A 107
ALA A 162
CYH A 163
GLU A 191
PHE A 202
HIS A 303
THR A 305
HIS A 340
LEU A 342
GLY A 399
 None
 0.63A 4ls7A-4r8eA:
69.3		 4ls7A-4r8eA:
52.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		7 / 12 GLY A 107
ALA A 162
GLU A 191
PHE A 202
LEU A 342
GLY A 399
PHE A 400
 None
 0.81A 4ls7A-4r8eA:
69.3		 4ls7A-4r8eA:
52.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		8 / 12 ALA A 162
CYH A 163
PHE A 202
HIS A 303
THR A 305
HIS A 340
LEU A 342
GLY A 399
 None
 0.65A 4ls7A-4r8eA:
69.3
4ls7B-4r8eA:
69.1		 4ls7A-4r8eA:
52.58
4ls7B-4r8eA:
52.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ALA A 162
PHE A 202
LEU A 342
GLY A 399
PHE A 400
 None
 0.86A 4ls7A-4r8eA:
69.3
4ls7B-4r8eA:
69.1		 4ls7A-4r8eA:
52.58
4ls7B-4r8eA:
52.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ILE A 108
ALA A 162
CYH A 163
HIS A 303
GLY A 399
 None
 0.82A 4ls7A-4r8eA:
69.3
4ls7B-4r8eA:
69.1		 4ls7A-4r8eA:
52.58
4ls7B-4r8eA:
52.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ALA A  79
GLY A  81
MET A 237
ASN A  18
PHE A  56
 None
 1.07A 4obwD-4r8eA:
undetectable		 4obwD-4r8eA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ALA A 235
ALA A 143
ILE A 104
GLY A  11
GLN A  83
 None
 1.05A 4r38A-4r8eA:
undetectable		 4r38A-4r8eA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ALA A 235
ALA A 143
ILE A 104
GLY A  11
GLN A  83
 None
 0.98A 4r38B-4r8eA:
undetectable		 4r38B-4r8eA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ALA A 235
ALA A 143
ILE A 104
GLY A  11
GLN A  83
 None
 1.03A 4r38C-4r8eA:
undetectable		 4r38C-4r8eA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ALA A 235
ALA A 143
ILE A 104
GLY A  11
GLN A  83
 None
 1.03A 4r38D-4r8eA:
undetectable		 4r38D-4r8eA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 GLY A 343
LEU A 407
ARG A 175
ALA A 173
HIS A 172
 None
 1.27A 4wcxC-4r8eA:
undetectable		 4wcxC-4r8eA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		4 / 7 CYH A 163
GLY A 405
ASN A 404
HIS A 303
 None
 1.22A 5a5zC-4r8eA:
undetectable		 5a5zC-4r8eA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 GLY A 171
ILE A 177
ALA A 187
GLY A 188
ALA A 103
 None
 0.91A 5kb6B-4r8eA:
undetectable		 5kb6B-4r8eA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		6 / 12 GLY A 144
ALA A 143
ILE A 157
GLY A 101
ILE A 100
ILE A 104
 None
 1.39A 5kqxA-4r8eA:
undetectable		 5kqxA-4r8eA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ILE A 104
GLY A 188
GLN A  83
ALA A 143
VAL A  78
 None
 1.26A 5n0xB-4r8eA:
undetectable		 5n0xB-4r8eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 ILE A 104
GLY A 189
GLN A  83
ALA A 143
VAL A  78
 None
 1.18A 5n0xB-4r8eA:
undetectable		 5n0xB-4r8eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 10 LEU A 240
ILE A 104
LEU A 146
ALA A  88
LEU A  90
 None
 1.18A 5y7pD-4r8eA:
undetectable		 5y7pD-4r8eA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Yersinia
pestis) 		5 / 12 VAL A 167
GLY A 171
ALA A 174
PHE A 409
VAL A 354
 None
 1.13A 6bqgA-4r8eA:
undetectable		 6bqgA-4r8eA:
12.22