SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 267
GLY A 428
ALA A 266
ILE A 429
 None
 0.72A 1gtnI-4r8fA:
undetectable
1gtnJ-4r8fA:
undetectable		 1gtnI-4r8fA:
10.21
1gtnJ-4r8fA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 245
LEU A 253
VAL A 446
ALA A 267
 None
 0.95A 1mz9A-4r8fA:
undetectable		 1mz9A-4r8fA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 386
THR A 383
ILE A 429
ALA A 340
ASP A 445
 None
 1.11A 2admB-4r8fA:
undetectable		 2admB-4r8fA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 310
ILE A 337
LEU A 338
SER A 339
 None
 0.98A 2byoA-4r8fA:
undetectable		 2byoA-4r8fA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 275
ILE A  71
ALA A 267
LEU A 291
ILE A  85
 None
 1.08A 2h42B-4r8fA:
undetectable		 2h42B-4r8fA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 452
GLY A 428
ALA A 340
LEU A 262
 None
 0.96A 3bgdA-4r8fA:
undetectable		 3bgdA-4r8fA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 422
LEU A 310
VAL A  84
SER A 318
THR A 424
 None
 1.28A 3freX-4r8fA:
undetectable		 3freX-4r8fA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 148
LEU A 222
LYS A 221
ILE A 131
LEU A 215
 None
 1.08A 3hj3B-4r8fA:
undetectable		 3hj3B-4r8fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 217
SER A 205
PHE A 208
PRO A 198
 None
 1.48A 3jqaC-4r8fA:
undetectable		 3jqaC-4r8fA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 270
LEU A  33
VAL A 313
THR A 288
LEU A 309
 None
 1.13A 3r9cA-4r8fA:
undetectable		 3r9cA-4r8fA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 311
TRP A 332
LYS A 306
 None
 1.35A 4k7aA-4r8fA:
undetectable		 4k7aA-4r8fA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 312
LEU A 328
VAL A 326
PHE A 286
LEU A 309
 None
 1.39A 4o8fB-4r8fA:
undetectable		 4o8fB-4r8fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 11 HIS A  88
ASP A 259
GLU A 295
GLU A 296
HIS A 435
 None
 0.43A 4pqaA-4r8fA:
20.3		 4pqaA-4r8fA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 148
LEU A 222
LYS A 221
ILE A 131
LEU A 215
 None
 1.14A 4q0dA-4r8fA:
undetectable		 4q0dA-4r8fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 148
LEU A 222
LYS A 221
ILE A 131
LEU A 215
 None
 1.14A 4q0dB-4r8fA:
undetectable		 4q0dB-4r8fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 148
LEU A 222
LYS A 221
ILE A 131
LEU A 215
 None
 1.14A 4q0dE-4r8fA:
undetectable		 4q0dE-4r8fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 368
GLY A 428
VAL A 397
VAL A 386
LEU A 389
 None
 1.16A 4qd3A-4r8fA:
4.8		 4qd3A-4r8fA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 341
HIS A  88
LYS A 410
 None
 0.80A 4qzuD-4r8fA:
undetectable		 4qzuD-4r8fA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 448
LEU A 345
ALA A 440
ALA A 430
GLY A 442
 None
 1.30A 4rn6A-4r8fA:
undetectable		 4rn6A-4r8fA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		3 / 3 THR A 301
ASN A 294
SER A 299
 None
 0.72A 4tvtA-4r8fA:
undetectable		 4tvtA-4r8fA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 304
LEU A 291
ILE A 297
GLY A 410
GLY A  86
 None
 1.11A 5d4uA-4r8fA:
undetectable		 5d4uA-4r8fA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 304
LEU A 291
ILE A 297
GLY A 410
GLY A  86
 None
 1.12A 5d4uB-4r8fA:
undetectable		 5d4uB-4r8fA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 447
GLY A 449
ILE A 269
PHE A  12
LEU A 253
 None
 1.13A 5fa8A-4r8fA:
undetectable		 5fa8A-4r8fA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 366
PHE A 453
LEU A 271
LEU A 416
LEU A 427
 None
 1.07A 5xxiA-4r8fA:
undetectable		 5xxiA-4r8fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 126
ILE A 160
ARG A 159
TYR A 108
 None
 1.02A 6hisA-4r8fA:
undetectable
6hisB-4r8fA:
undetectable		 6hisA-4r8fA:
11.78
6hisB-4r8fA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 126
ILE A 160
ARG A 159
TYR A 108
 None
 1.02A 6hisB-4r8fA:
undetectable
6hisC-4r8fA:
undetectable		 6hisB-4r8fA:
11.78
6hisC-4r8fA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 126
ILE A 160
ARG A 159
TYR A 108
 None
 1.02A 6hisC-4r8fA:
undetectable
6hisD-4r8fA:
undetectable		 6hisC-4r8fA:
11.78
6hisD-4r8fA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 126
ILE A 160
ARG A 159
TYR A 108
 None
 1.01A 6hisD-4r8fA:
undetectable
6hisE-4r8fA:
undetectable		 6hisD-4r8fA:
11.78
6hisE-4r8fA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4r8f VACUOLAR
AMINOPEPTIDASE 1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 108
ASP A 126
ILE A 160
ARG A 159
 None
 1.02A 6hisA-4r8fA:
undetectable
6hisE-4r8fA:
undetectable		 6hisA-4r8fA:
11.78
6hisE-4r8fA:
11.78