SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4r8g UNCONVENTIONAL
MYOSIN-IC
(Mus
musculus) 		3 / 3 GLN E 960
ILE E 999
HIS E1017
 None
 0.74A 1k74A-4r8gE:
undetectable		 1k74A-4r8gE:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4r8g UNCONVENTIONAL
MYOSIN-IC
(Mus
musculus) 		4 / 8 ILE E 932
SER E 933
SER E 940
LEU E 968
 None
 0.89A 2cdqA-4r8gE:
undetectable		 2cdqA-4r8gE:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4r8g UNCONVENTIONAL
MYOSIN-IC
(Mus
musculus) 		5 / 12 LEU E 879
THR E 908
VAL E 915
VAL E 912
ILE E 884
 None
 1.23A 3bf1A-4r8gE:
undetectable
3bf1B-4r8gE:
undetectable		 3bf1A-4r8gE:
19.49
3bf1B-4r8gE:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4r8g UNCONVENTIONAL
MYOSIN-IC
(Mus
musculus) 		3 / 3 THR E 989
HIS E 945
ASN E 982
 None
 0.97A 5n4tA-4r8gE:
undetectable		 5n4tA-4r8gE:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4r8g UNCONVENTIONAL
MYOSIN-IC
(Mus
musculus) 		3 / 3 GLN E 960
ILE E 999
HIS E1017
 None
 0.64A 5z12B-4r8gE:
undetectable		 5z12B-4r8gE:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4r8g UNCONVENTIONAL
MYOSIN-IC
(Mus
musculus) 		4 / 6 VAL E 912
LEU E 905
LEU E 959
LEU E 968
 None
 1.03A 6f6sA-4r8gE:
undetectable
6f6sB-4r8gE:
undetectable		 6f6sA-4r8gE:
12.91
6f6sB-4r8gE:
13.76