SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 12 ALA A 254
LEU A 251
LEU A 241
LEU A 291
LEU A 260
 None
 0.99A 1g5yB-4r8lA:
undetectable		 1g5yB-4r8lA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 6 SER A 325
THR A 324
LEU A 321
ASP A 322
 None
 1.23A 1mxdA-4r8lA:
undetectable		 1mxdA-4r8lA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.18A 2eimJ-4r8lA:
undetectable		 2eimJ-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.24A 2eimW-4r8lA:
undetectable		 2eimW-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 9 ALA A 120
ALA A 123
SER A 127
PHE A 128
ALA A 327
 None
 1.12A 2vh3A-4r8lA:
undetectable		 2vh3A-4r8lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 6 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.08A 3abmA-4r8lA:
undetectable
3abmJ-4r8lA:
undetectable		 3abmA-4r8lA:
23.21
3abmJ-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.07A 3ag1J-4r8lA:
undetectable		 3ag1J-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 6 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.03A 3ag1N-4r8lA:
undetectable
3ag1W-4r8lA:
undetectable		 3ag1N-4r8lA:
23.21
3ag1W-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.27A 3ag2J-4r8lA:
undetectable		 3ag2J-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.08A 3ag4J-4r8lA:
undetectable		 3ag4J-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		3 / 3 GLU A 171
VAL A 172
CYH A 173
 None
 1.05A 3fbxA-4r8lA:
undetectable		 3fbxA-4r8lA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		3 / 3 PRO A  81
LEU A  82
GLN A  80
 None
 0.68A 3hznG-4r8lA:
undetectable
3hznH-4r8lA:
undetectable		 3hznG-4r8lA:
21.30
3hznH-4r8lA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 7 GLU A 348
GLN A 347
VAL A 318
ALA A 351
 None
 1.07A 3kp6B-4r8lA:
undetectable		 3kp6B-4r8lA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 8 LEU A  13
TYR A  15
LEU A  39
TYR A  74
 None
 0.89A 3v81C-4r8lA:
undetectable		 3v81C-4r8lA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 7 LEU A  13
TYR A  15
LEU A  39
TYR A  74
 None
 1.14A 4b3qA-4r8lA:
undetectable		 4b3qA-4r8lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		3 / 3 PRO A 339
ASN A 233
HIS A 231
 None
 0.87A 4ma3H-4r8lA:
undetectable
4ma3L-4r8lA:
undetectable		 4ma3H-4r8lA:
20.67
4ma3L-4r8lA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 8 LEU A  13
TYR A  15
LEU A  39
TYR A  74
 None
 0.85A 4pwdC-4r8lA:
undetectable		 4pwdC-4r8lA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		3 / 3 LEU A  20
ILE A 113
TYR A  74
 None
 0.66A 5uunB-4r8lA:
undetectable		 5uunB-4r8lA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 9 ASP A  84
GLY A  18
GLY A 115
ALA A 142
MET A  22
 ASP  A 700 (-3.0A)
ASP  A 700 ( 3.7A)
ASP  A 700 (-3.4A)
None
None
 1.30A 5v3cA-4r8lA:
undetectable		 5v3cA-4r8lA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.29A 5w97J-4r8lA:
undetectable		 5w97J-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.08A 5wauJ-4r8lA:
undetectable		 5wauJ-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.00A 5x19J-4r8lA:
undetectable		 5x19J-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.01A 5x1bJ-4r8lA:
undetectable		 5x1bJ-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.05A 5x1bW-4r8lA:
undetectable		 5x1bW-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 6 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.00A 5x1fA-4r8lA:
undetectable
5x1fJ-4r8lA:
undetectable		 5x1fA-4r8lA:
23.21
5x1fJ-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.14A 5x1fW-4r8lA:
undetectable		 5x1fW-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 9 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.30A 6czmA-4r8lA:
undetectable
6czmB-4r8lA:
undetectable		 6czmA-4r8lA:
23.98
6czmB-4r8lA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 9 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.32A 6czmB-4r8lA:
undetectable
6czmC-4r8lA:
undetectable		 6czmB-4r8lA:
23.98
6czmC-4r8lA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 10 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.30A 6czmE-4r8lA:
undetectable
6czmF-4r8lA:
undetectable		 6czmE-4r8lA:
23.98
6czmF-4r8lA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		5 / 11 LEU A 139
HIS A 114
GLY A 115
PHE A 197
ALA A 196
 None
None
ASP  A 700 (-3.4A)
None
None
 1.15A 6ieyA-4r8lA:
undetectable
6ieyB-4r8lA:
undetectable		 6ieyA-4r8lA:
20.96
6ieyB-4r8lA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.03A 6nknJ-4r8lA:
undetectable		 6nknJ-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 5 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 1.38A 6nknW-4r8lA:
undetectable		 6nknW-4r8lA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4r8l UNCHARACTERIZED
PROTEIN
(Cavia
porcellus) 		4 / 7 ARG A 182
MET A 358
THR A 359
LEU A 360
 None
 0.96A 6nmpA-4r8lA:
undetectable
6nmpJ-4r8lA:
undetectable		 6nmpA-4r8lA:
23.21
6nmpJ-4r8lA:
11.04