SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3
(Homo
sapiens) 		5 / 12 VAL L 302
ILE L 299
ILE L 254
PHE L 256
ARG L 205
 None
 1.04A 1qhsA-4r8pL:
undetectable		 1qhsA-4r8pL:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3
(Homo
sapiens) 		5 / 12 VAL L 302
ILE L 299
ILE L 254
PHE L 256
ARG L 205
 None
 0.98A 1qhyA-4r8pL:
undetectable		 1qhyA-4r8pL:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3
(Homo
sapiens) 		4 / 5 HIS L 275
PRO L 276
TYR L 245
PRO L 244
 None
 1.44A 2ombA-4r8pL:
undetectable
2ombB-4r8pL:
undetectable		 2ombA-4r8pL:
22.96
2ombB-4r8pL:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3
(Homo
sapiens) 		4 / 5 HIS L 275
PRO L 313
TYR L 334
PRO L 244
 None
 1.50A 2ombA-4r8pL:
undetectable
2ombB-4r8pL:
undetectable		 2ombA-4r8pL:
22.96
2ombB-4r8pL:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3
(Homo
sapiens) 		5 / 12 PRO L 265
ILE L 288
LEU L 303
LEU L 286
ILE L 306
 None
 1.21A 3a50E-4r8pL:
undetectable		 3a50E-4r8pL:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3
(Homo
sapiens) 		5 / 12 THR L 298
ILE L 254
ALA L 223
THR L 236
ILE L 237
 None
 1.23A 3ddyA-4r8pL:
undetectable		 3ddyA-4r8pL:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3
(Homo
sapiens) 		4 / 6 LYS L 301
LEU L 304
PRO L 218
ARG L 205
 None
 1.42A 4yv5B-4r8pL:
undetectable		 4yv5B-4r8pL:
17.60