SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		4 / 5 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 1.00A 1rs7A-4r8uB:
undetectable		 1rs7A-4r8uB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		4 / 6 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 1.02A 1rs7B-4r8uB:
undetectable		 1rs7B-4r8uB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		4 / 5 LEU B 198
ALA B 195
LEU B 193
SER B 189
 None
 1.11A 1tt6B-4r8uB:
undetectable		 1tt6B-4r8uB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		4 / 6 ALA B 106
SER B 102
PHE B  91
ASP B 104
 None
None
None
MG  B 402 ( 3.2A)
 0.99A 1yc2A-4r8uB:
undetectable		 1yc2A-4r8uB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		4 / 7 SER B  84
SER B  92
ARG B  93
GLU B 134
 None
 0.80A 2cdqB-4r8uB:
3.1		 2cdqB-4r8uB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		5 / 12 SER B 140
VAL B   8
ILE B 127
PHE B  91
HIS B  86
 None
 1.31A 2vdyB-4r8uB:
undetectable		 2vdyB-4r8uB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		5 / 12 VAL B   8
ARG B 128
ILE B 127
PHE B  91
HIS B  86
 None
 1.38A 2vdyB-4r8uB:
undetectable		 2vdyB-4r8uB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		5 / 11 ALA B  16
ILE B  30
SER B  56
ILE B  42
TYR B  80
 None
None
1FZ  B 401 (-3.6A)
None
None
 1.06A 2w9sA-4r8uB:
undetectable		 2w9sA-4r8uB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		5 / 11 ALA B  16
ILE B  30
SER B  56
ILE B  42
TYR B  80
 None
None
1FZ  B 401 (-3.6A)
None
None
 1.03A 2w9sB-4r8uB:
undetectable		 2w9sB-4r8uB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		5 / 10 ALA B  16
ILE B  30
SER B  56
ILE B  42
TYR B  80
 None
None
1FZ  B 401 (-3.6A)
None
None
 1.03A 2w9sC-4r8uB:
undetectable		 2w9sC-4r8uB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		4 / 7 LEU B 223
ALA B 180
GLY B 186
PHE B 219
 None
 0.96A 2wq5A-4r8uB:
undetectable		 2wq5A-4r8uB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		5 / 11 ALA B  49
GLY B  53
LEU B  70
LEU B  64
ALA B  63
 None
 1.14A 3kw2A-4r8uB:
undetectable		 3kw2A-4r8uB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		4 / 5 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 0.97A 4d33A-4r8uB:
undetectable		 4d33A-4r8uB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		4 / 5 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 1.02A 4d33B-4r8uB:
undetectable		 4d33B-4r8uB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		4 / 6 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 1.00A 4d39B-4r8uB:
undetectable		 4d39B-4r8uB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4r8u DNA POLYMERASE IV
(Escherichia
coli) 		4 / 6 GLY B 220
ILE B 222
TRP B 224
VAL B 204
 None
 1.03A 4kcnA-4r8uB:
undetectable		 4kcnA-4r8uB:
20.88